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Cell Cycle ; 20(24): 2652-2661, 2021 12.
Article in English | MEDLINE | ID: mdl-34843421

ABSTRACT

In fission yeast, MBF-dependent transcription is required for cells to complete S phase. The MBF transcription factor is regulated through a complex feedback mechanism that involves the co-repressors Yox1 and Nrm1 that are loaded onto MBF at the end of S phase, while positive transactivation is achieved through the constitutive binding of the co-activator Rep2. Here we show that Rep2 is required to fully recruit the chromatin remodelers SWI/SNF and RSC to MBF-regulated promoters. On the contrary, Nrm1 and Yox1, when bound to the MBF complex, block the approximation of these chromatin remodelers to MBF-regulated promoters. We propose that SWI/SNF and RSC are recruited to MBF-regulated genes, and RSC together with SAGA complex are important to regulate the G1-to-S transcriptional wave. Mutants of these remodeler complexes are highly sensitive when cells are exposed to insults that challenge DNA synthesis.


Subject(s)
Cell Cycle Proteins/genetics , Promoter Regions, Genetic , Schizosaccharomyces pombe Proteins/genetics , Schizosaccharomyces , Transcription Factors/genetics , Cell Cycle Proteins/metabolism , Chromatin/metabolism , Homeodomain Proteins/metabolism , Promoter Regions, Genetic/genetics , Repressor Proteins/metabolism , Schizosaccharomyces pombe Proteins/metabolism , Trans-Activators/metabolism , Transcription Factors/metabolism
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