ABSTRACT
Retrospective analysis of data from a chronic (2-year) rat (Rattus norvegicus) carcinogenicity study was performed to compare the incidence of foot lesion development relative to cage type and animal supplier. Groups of rats from two different suppliers were housed in wire-bottom or polycarbonate cages. Clinical observations and body weights were collected. Data were analyzed to determine foot lesion occurrence, time to onset of foot lesions, and body weight change over time. Noteworthy abnormalities of the plantar surface of the hind foot (i.e., ulcers or nodular swellings) were more common in heavier rats than in lighter animals of the same sex (but different source), and abnormalities were more common in rats housed in wire cages than polycarbonate cages. However, despite differences in weight, cage type, and supplier, lesions were not found until the rats had been housed for more than 1 year.
Subject(s)
Animals, Laboratory , Foot Diseases/veterinary , Housing, Animal , Rodent Diseases , Animals , Body Weight , Callosities/epidemiology , Callosities/etiology , Callosities/veterinary , Edema/epidemiology , Edema/etiology , Edema/veterinary , Female , Foot Diseases/epidemiology , Foot Diseases/etiology , Foot Ulcer/epidemiology , Foot Ulcer/etiology , Foot Ulcer/veterinary , Male , Polycarboxylate Cement , Rats , Rats, Sprague-Dawley , Time FactorsSubject(s)
Arthritis, Juvenile/veterinary , Dog Diseases/diagnosis , Fever/veterinary , Leukocytosis/veterinary , Animals , Arthritis, Juvenile/diagnosis , Arthritis, Juvenile/pathology , Blood Platelets/pathology , Dog Diseases/pathology , Dogs , Fever/etiology , Gait , Leukocytosis/etiology , Male , Myocardium/pathology , Necrosis , Saliva , Vasculitis/pathology , Vasculitis/veterinaryABSTRACT
Proliferative ileitis of hamsters is consistently associated with the presence of intracellular bacteria in affected ileal epithelial cells. The 16S rRNA gene sequence of the putative etiologic agent of proliferative ileitis was determined by using cell culture-maintained organisms. The highest level of relatedness (98.4%) was observed with a newly described obligately intracellular bacterium obtained from porcine intestines, and the level of homology with Desulfovibrio desulfuricans was 87.5%.
