Live neonates born to mothers with Ebola virus disease: a review of the literature.

Ebola virus disease (EVD) is associated with a high mortality, especially among neonates. There is a paucity of literature on live neonates born to pregnant women with EVD, and therefore, our understanding of their clinical illness and outcomes is extremely limited. A literature search was conducted to identify descriptions of live neonates born to pregnant women with EVD. To date, five known reports have provided limited information about 15 live neonates born to pregnant women with EVD. All 15 neonates died, and of those with information, death was within 19 days of birth. Of the 12 neonates with information on signs and symptoms, 8 (67%) were reported to have fever; no other signs or symptoms were reported. There are no published data describing the clinical course or treatments provided for these neonates. Potential modes of Ebola virus transmission from mother to neonate are through in utero transmission, during delivery, direct contact or through breast milk. There is an urgent need for more information about neonates with EVD, including clinical course (for example, onset and presentation of illness, symptomatology and course of illness) and treatments provided as well as information on Ebola viral load in breast milk from Ebola-positive and convalescing mothers.

Developing a service to monitor and improve physical health in people with serious mental illness.

Developing effective models of identifying and managing physical health problems amongst mentally ill populations has become a more pressing issue in recent years as the prescription of Second Generation Antipsychotics (SGAs) has burgeoned. Some of the side effects commonly associated with SGAs such as weight gain and metabolic disorders have potentially devastating effects on health and well-being, increasing cardiovascular risk and the incidence of diabetes. The Well-Being Support Programme (WSP), a nurse-led service, was designed to provide a care delivery system whereby physical problems could be identified and appropriate treatment and monitoring initiated by prompt referral to suitable specialist services or general practitioners, forging strong links between primary and secondary care and ensuring that mentally ill patients with physical health problems were receiving holistic care packages. Other problems such as unhealthy lifestyles and obesity were managed by the Nurse Advisor running the programme. Interventions such as weight counselling and groups, and structured exercise programmes were beneficial in terms of encouraging healthier lifestyles, managing obesity and improving self-esteem. This paper describes the manner in which the service was set up and implemented, demonstrating an effective model for identifying and managing physical health problems in the mentally ill.

Cell culture studies of a carborane cholesteryl ester with conventional and PEG liposomes.

A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could be adequately taken up by 9L rat glioma cells in cell culture. Several factors potentially affecting the cellular uptake were evaluated, such as concentration of BCH in the incubation medium, incubation time, cell confluence, and the addition of polyethylene glycol (PEG) phospholipids to the liposomal formulation. The studies indicated that the cellular uptakes of BCH in the conventional and PEG liposomal formulations were 49.1 and 45.9 microg boron/g cells, respectively. Therefore, this compound, formulated in both liposomal formulations, delivered sufficient levels of boron to cancer cells in vitro, indicating that BCH is a promising approach for use in BNCT. The uptake appeared to depend upon BCH concentration in the media as well as the confluence of the cells. The greater boron uptake by nonconfluent cells indicated that active growth of cells was a factor in the uptake of this compound.

Targeted drug delivery for brain cancer treatment.

The blood brain barrier (BBB) and the systemic toxicity of conventional chemotherapy present obstacles to the success of future blood-borne drug therapies of brain tumors. The work with polymer-encapsulated cancer drugs suggests an alternative and more focused treatment approach. Our experimental strategy integrates direct intracerebral drug delivery, sustained drug release from liposomes or polymer implants, and increased targeting of the drug either by chemically modifying the drug or by using tumor-specific carriers. This review will present some of the recent work on targeted drug delivery for brain cancer treatment.

Myxoid leiomyosarcoma of the uterus: case report and review of the literature.

A case of myxoid leiomyosarcoma of the uterus is presented as a rare variant of uterine sarcoma. Only 10 previous cases have been described in the literature. These tumors have a striking myxoid appearance and exhibit highly malignant behavior despite their low mitotic index.