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Bull Exp Biol Med ; 158(4): 497-9, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25708334

ABSTRACT

Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia.


Subject(s)
Blood Coagulation Disorders/physiopathology , Leukemia P388/physiopathology , Neovascularization, Pathologic/physiopathology , Vascular Endothelial Growth Factor A/blood , Animals , Enzyme-Linked Immunosorbent Assay , Male , Mice , Neoplasm Transplantation/physiology , Neovascularization, Pathologic/blood , Partial Thromboplastin Time , Prothrombin Time , Statistics, Nonparametric
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