[Virulence of plasmids of diarrhea-causing strains of Salmonellae wien and Escherichia coli]. / Ispitivanje plazmida virulencije u sojeva Salmonellae wien i Escherichia coli uzrocnika dijereje.

Use of molecular genetic methods in the study of sources and ways of spreading the infection provides precise data on the mutual clonal origin of the strains, on the basis of the determination of plasmid DNK maps. Results of the investigation of Salmonellae Wien strain show the same type of resistance to antimicrobial drugs and the impact of resistotypization as an epidemiologic marker. The analysis of the plasmid profile in these strains has confirmed the presence of FIme virulence plasmid of 80 megadalton in size and resistance plasmid of 60 megadalton which was by conjugation transferred to the recipient strain (in vitro experiment). The presence of antigen factors of colonization in escherichial coli, a cause of diarrhea, was confirmed: CFA-I in the serogroup 078, and CFA-II in the serogroup 06.

[Prophylaxis and therapy of infections in allogenic bone marrow transplantation in patients with hematologic diseases]. / Profilaksa i lecenje infekcije kod alogene transplantacije kosne srzi bolesnika sa hematoloskim oboljenjima.

Infection and acute graft versus host disease (GVHD) are the most common complications of allogeneic bone marrow transplantation, which compromise this therapeutical method for hematologic diseases. Beside the appreciation of customary preventive measures and the treatment of infections, it is necessary for every bone marrow transplantation center to analyze the development of bacterial, fungal and viral infections in the patients and to generate the most efficient and most rational program for their prevention and treatment. At the Hematology Department in Novi Sad seven allogenic bone marrow transplantations were performed in patients with malignant hematologic diseases and severe form of aplastic anemia. Prevention of the infection by isolation of the patient in a sterile unit, selective decontamination of the digestive tract with sterile food, skin and mucus hygiene and prophylactic drug administration proved rather beneficial and adequate for patients with the graft accepted, hematopoiesis recovered and immunity reconstructed. Risks of infections were increased by permanent vein catheter, acute GVHD and rejection of the bone marrow graft. Prompt isolation and identification of bacteria and fungi, especially in blood, the establishment of a minimal suppressing and bactericide antibiotic concentration, along with the assessment of their synergism, as well as early diagnosis of cytomegalovirus and administration of specific drugs, can significantly contribute to the more successful treatment of infections in transplanted patients.

[Current results and methods in eradication of typhus fever on the Serbian territory excluding autonomic provinces]. / Dosadasnji rezultati i metode u eradikaciji pegavog tifusa na teritoriji Srbije van autonomnih pokrajina

Since 1969 Serbia has been conducting the programme of eradication louse-borne typhus. To this effect of Law on the eradication of communicable diseases has been passed. In addition to Republic Commission, as well as 6 regional commissions, and 18 communal commissions in whose territory the disease is being eradicated, have been formed. The operations consist of four phases: preparatory attack, consolidation and final phase. The methods and measures applied under the programme include the measures concerned with the control of vectors, i.e. lousiness, measures to detect the source of infection, respectively patients with louse-borne typhus and Brill-Zinsser disease. The control of louseiness effected through the impregnation of underwears and bed linens by means of syntheic insecticides (DDT, Maltox), as well as through health education activities, has yielded good results, so that the highest rate of lousiness: 9.08% (Sjenica, Tutin 4.37%), was reduced to less than 1% in 1972. To detect the source of infection, both active and pasiive investigation has been carried out. Active investigation included regular control of the health state through thermometry applied to registered households with lice. Passive investigation is carried out trough out -patient units and residential services which take care of all febrile patients coming from endemic areas. The results obtained from the three-year operations indicate that the percentage of dected patients with Brill-Zinsser amounts to 0--4--3.9%, as well as that it is still lagging behind with respect to the immunity acquired through previous affections in the endemic areas. The distribution of detected patients with Brill-Zinsser especially indicates that a small number of patients from endemic ares has been detected. The paper presents the criteria for the evaluation of results, making a proposal that a professional body should be formed at the federal level to coordinate the methods and programmes of operations. In addition that body's task would be to expand the operations to all endemic areas in the country.