ABSTRACT
The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
Subject(s)
Amino Acids/chemistry , Receptors, AMPA/antagonists & inhibitors , Triazoles/chemistry , Amino Acids/chemical synthesis , Amino Acids/pharmacology , Binding Sites , Catalysis , Computer Simulation , Copper/chemistry , Ligands , Receptors, AMPA/metabolism , Ruthenium/chemistryABSTRACT
A mixture of [(2)H(7)]-geraniol, [(2)H(7)]-nerol, [(2)H(7)]-linalool and [(2)H(7)]-alpha-terpineol was prepared for use as internal standards in a rapid and accurate analytical method, employing gas chromatography-mass spectrometry (GC/MS), to determine the concentration of geraniol, nerol, linalool and alpha-terpineol in wine. The method avoids the possible formation, degradation and interconversion of these compounds during their analysis.
