ABSTRACT
This article is concerned with a prospective study about the systematical, simultaneous and comparative assay of four biological markers (carcino-embryonic antigen, lactate dehydrogenase, gammaglutamyl transferase and phosphohexose isomerase). This study was conducted in a department of Hematology and oncology on 258 patients. The dosage of each marker separately does not appear to be of diagnostical interest because of a lack of sensibility and specificity. But when there is a positive statistical correlation between several makers, their simultaneous dosage may allow the diagnostic of cancer and sometimes the determination of its origin.
Subject(s)
Carcinoembryonic Antigen/analysis , Glucose-6-Phosphate Isomerase/blood , L-Lactate Dehydrogenase/blood , Neoplasms/blood , gamma-Glutamyltransferase/blood , Adult , Aged , Female , Humans , Leukemia/blood , Lymphoma/blood , Male , Middle Aged , Prospective StudiesSubject(s)
Heart Neoplasms/complications , Myxoma/complications , Ultrasonography , Aged , Female , Humans , Pericarditis/etiologySubject(s)
Anemia, Hemolytic, Autoimmune/etiology , Lymphoma/etiology , Sarcoidosis/complications , Female , Humans , Middle Aged , Time FactorsSubject(s)
Polyradiculoneuropathy/etiology , Waldenstrom Macroglobulinemia/complications , Aged , Female , HumansSubject(s)
Multiple Sclerosis/genetics , Purpura, Thrombocytopenic/genetics , Adult , Autoimmune Diseases/genetics , Female , Humans , Immunity, Cellular , Multiple Sclerosis/complications , Multiple Sclerosis/immunology , Purpura, Thrombocytopenic/complications , Purpura, Thrombocytopenic/immunologyABSTRACT
The case of a 52-year-old patient with systemic amylosis diagnosed upon examination of an osteomedullary biopsy specimen is reported. The most prominent clinical manifestation was a major hemorrhagic syndrome which was recognized as being a result of severe factor Stuart deficiency. The new classification of amyloses based on the latest biochemical and immunological findings is recalled. Current physiopathogenic speculations put emphasis on plasmocyte-macrophage cooperation. Lastly, factor Stuart deficiency, which is as classical as it is uncommon, could originate in the particular affinity of amyloid fibers for this factor and in a "mass effect" (quantity of amyloid substance directly exposed to blood flow), explaining why splenectomy is effective in some instances.