ABSTRACT
Objetivo: Evaluar la relación entre el potencial relacionado a eventos P300 con significado atencional visual y los resultados de la evaluación neuropsicológica en pacientes conenfermedad de Parkinson en estadios II y III de Hoehn y Yahr.Métodos: Se realizó un estudio analítico transversal donde se evaluaron 57 pacientes con enfermedad de Parkinson idiopática, atendidos entre diciembre de 2017 y abril de 2018, en el Centro Internacional de Restauración Neurológica, de La Habana. Se realizó el registro de P300, durante la ejecución de una tarea de atención sostenida visual. Se midió latencia y amplitud de la P300, lo que se correlacionó (test de correlaciones de Spearman, p< 0,01)con las variables demográficas, variables de eficiencia en la tarea de atención sostenida y variables neuropsicológicas. Se compararon los resultados de los grupos II y III de Hoehn y Yahr con respecto a todas las variables estudiadas (test de la U de Mann Whitney, p< 0,05).Resultados: Se constató una significativa diferencia de latencia entre grupos del componente P300 en el electrodo Pz. Fue más prolongado en el grupo III de Hoehn y Yahr.Se evidenciaron en el grupo II correlaciones negativas entre la latencia de P300 y el test de batería de evaluación frontal, y positivas entre la latencia de P300 y la prueba de Stroop.Las correlaciones entre el test de ba(AU)
Objective: To evaluate the relationship between the P300 event-related potential with visual attention significance and the results of neuropsychological evaluation in patientswith Parkinson's disease in Hoehn and Yahr stages II and III.Methods: A cross-sectional analytical study was carried out evaluating 57 patients with idiopathic Parkinson's disease, who were treated from December 2017 to April 2018 at theInternational Center for Neurological Restoration, in Havana. P300 was recorded during the execution of a visual sustained attention task. The latency and amplitude of P300 weremeasured, which was correlated (Spearman's correlation test, p <0.01) with demographic variables, efficiency variables in the sustained attention task and neuropsychological variables. The results of Hoehn and Yahr groups II and III were compared with respect to all the variables studied (Mann Whitney U test, p <0.05).Results: Significant latency difference was found between groups of P300 component in Pz electrode. It was more prolonged in Hoehn and Yahr group III. Negative correlations were found in group II between P300 latency and the frontal evaluation battery test, andpositive correlations between P300 latency and Stroop test. The correlations between the frontal evaluation battery test and P300 amplitude were positive, and between Stroop test and P300 amplitude were negative. Similar results were evident in group III regarding P300 amplitude, which corresponded to worse performance in the neuropsychological evaluation.Conclusions: A close relationship between P300 event-related potential with visual attention significance and the results of the neuropsychological evaluation in Parkinson's disease patients, in Hoehn and Yahr stages II and III, was verified. P300 potential was an objective examination that reinforced the validity of the neuropsychological evaluationresults(AU)
Subject(s)
Humans , Male , Female , Middle Aged , Parkinson Disease/diagnosis , Parkinson Disease/drug therapy , Event-Related Potentials, P300 , Antiparkinson Agents/administration & dosage , Antiparkinson Agents/therapeutic use , Neuropsychological Tests , ElectroencephalographyABSTRACT
Patients diagnosed with Parkinson's disease present sleep disorders with a higher frequency than the general population. The sleep architecture in these patients shows variations with respect to the normal population, so in this work it was decided to investigate the characteristics of the macroarchitecture of sleep in patients diagnosed with Parkinson's disease. A polysomnographic study was carried out on 77 patients diagnosed with Parkinson's disease. All the studies were processed according to the AASM Manual for the Scoring of Sleep and Associated Events v.2.2, and to the criteria of the International Classification of Sleep Disorders 3rd ed. (2014). Processing was carried out using descriptive statistics, as well as non-parametric analysis for comparison between cases and controls. The group of patients showed significant reductions of the N2, N3, and REM sleep stages when compared with a control group, as well as a significant increase in intra-sleep wakefulness. The number of REMâ»NoREM sleep cycles and sleep efficiency showed marked reduction compared to the control group. There was a statistically significant difference in the macroarchitecture of sleep between patients diagnosed with Parkinson's disease and healthy controls.
