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1.
BMC Health Serv Res ; 24(1): 644, 2024 May 20.
Article in English | MEDLINE | ID: mdl-38769529

ABSTRACT

BACKGROUND: This paper aims to instigate discussion and publication of methodologies applied to enhance quality management through comprehensive scientific reports. It provides a detailed description of the design, implementation, and results of the quality control program employed in the SMESH study. METHODS: Cross-sectional, multicenter, national study designed to assess the prevalence of human papillomavirus in sex workers and in men who have sex with men (MSM). Respondent-driven sampling recruitment was used. An online system was developed for the study and checkpoints were defined for data entry. The system checked the quality of biological samples and performed a retest with part of the sample. RESULTS: A total of 1.598 participants (442 sex workers and 1.156 MSM) were included. Fifty-four health professionals were trained for face-to-face data collection. The retest showed Kappa values ranging between 0.3030 and 0.7663. CONCLUSION: The retest data were mostly classified as indicating a strong association. The data generated by the checkpoints showed the successful implementation of the quality control program.


Subject(s)
Papillomavirus Infections , Humans , Cross-Sectional Studies , Male , Papillomavirus Infections/prevention & control , Sex Workers/statistics & numerical data , Homosexuality, Male/statistics & numerical data , Adult , Female , Quality Control , Prevalence
2.
Gynecol Oncol ; 176: 130-138, 2023 09.
Article in English | MEDLINE | ID: mdl-37524011

ABSTRACT

OBJECTIVE: To relate the distance traveled from the patient's residence to the gestational trophoblastic neoplasia (GTN) reference center (RC) and the occurrence of unfavorable clinical outcomes, as well as to estimate the possible association between this distance and the risk of metastatic disease at presentation, the need for multiagent chemotherapy to achieve remission and loss to follow-up before remission. STUDY DESIGN: Retrospective historical cohort study of patients with GTN followed at 8 Brazilian GTN-RC, from January 1st, 2000 - December 31st, 2017. RESULTS: Evaluating 1055 cases of GTN, and using a receiver operating characteristic curve, we found a distance of 56 km (km) from the residence to the GTN-RC (sensitivity = 0.57, specificity = 0.61) best predicted the occurrence of at least one of the following outcomes: occurrence of metastatic disease, need for multiagent chemotherapy to achieve remission, or loss to follow-up during chemotherapy. Multivariate logistic regression adjusted by age, ethnicity, marital status and the reference center location showed that when the distance between residence and GTN-RC was ≥56 km, there was an increase in the occurrence of metastatic disease (relative risk - RR:3.27; 95%CI:2.20-4.85), need for multiagent chemotherapy (RR:1.36; 95%CI:1.05-1.76), loss to follow-up during chemotherapy (RR:4.52; 95CI:1.93-10.63), occurrence of chemoresistance (RR:4.61; 95%CI:3.07-6.93), relapse (RR:10.27; 95%CI:3.08-34.28) and death due to GTN (RR:3.62; 95%CI:1.51-8.67). CONCLUSIONS: The distance between the patient's residence and the GTN-RC is a risk factor for unfavorable outcomes, including death from this disease. It is crucial to guarantee these patients get prompt access to the GTN-RC and receive follow-up support.


Subject(s)
Gestational Trophoblastic Disease , Neoplasm Recurrence, Local , Pregnancy , Humans , Female , Retrospective Studies , Cohort Studies , Brazil/epidemiology , Gestational Trophoblastic Disease/pathology , Risk Factors
3.
Gynecol Oncol ; 170: 179-185, 2023 03.
Article in English | MEDLINE | ID: mdl-36706644

ABSTRACT

OBJECTIVE: To describe the natural history of hydatidiform mole (HM) after intracytoplasmic sperm injection (ICSI), emphasizing the clinical and oncological outcomes, as compared to patients who had HM after spontaneous conception (SC). STUDY DESIGN: Retrospective historical cohort study of patients with HM followed at the Rio de Janeiro Federal University, from January 1st 2000-December 31st 2020. RESULTS: Comparing singleton HM after SC to those following ICSI there were differences in terms of maternal age (24 vs 34 years, p < 0.01), gestational age at diagnosis (10 vs 7 weeks, p < 0.01), preevacuation human chorionic gonadotropin levels (200,000 vs 99,000 IU/L, p < 0.01), occurrence of genital bleeding (60.5 vs 26.9%, p < 0.01) and hyperemesis (23 vs 3.9%, p = 0.02) at presentation, and time to remission (12 vs 5 weeks, p < 0.01), respectively. There were no differences observed in the cases of twin mole, regardless of the form of fertilization that gave rise to HM, except molar histology with greater occurrence of partial hydatidiform mole (10.7 vs 40.0%, p = 0.01) following ICSI. Univariate logistic regression for occurrence of postmolar GTN after ICSI identified no predictor variable for this outcome. However, after adjusting for maternal age and complete hydatidiform mole histology, multivariable logistic regression showed the risk of GTN with HM after ICSI had an adjusted odds ratio of 0.22 (95%CI:0.05-0.93, p = 0.04), suggesting a possible protective effect when compared to HM after SC. CONCLUSIONS: Singleton HM after ICSI are diagnosed earlier in gestation, present with fewer medical complications, and may be less likely to develop GTN when compared with HM after SC.


Subject(s)
Gestational Trophoblastic Disease , Hydatidiform Mole , Uterine Neoplasms , Male , Pregnancy , Female , Humans , Adult , Infant , Retrospective Studies , Sperm Injections, Intracytoplasmic , Cohort Studies , Brazil , Semen , Hydatidiform Mole/pathology , Gestational Trophoblastic Disease/pathology , Fertilization , Chorionic Gonadotropin , Uterine Neoplasms/pathology
4.
BJOG ; 130(3): 292-302, 2023 02.
Article in English | MEDLINE | ID: mdl-36209485

ABSTRACT

OBJECTIVE: To assess whether the incidence and aggressiveness of molar pregnancy (MP) and postmolar gestational trophoblastic neoplasia (GTN) changed during the COVID-19 pandemic. DESIGN: Observational study with two separate designs: retrospective multicentre cohort of patients with MP/postmolar GTN and a cross-sectional analysis, with application of a questionnaire. SETTING: Six Brazilian Reference Centres on gestational trophoblastic disease. POPULATION: 2662 patients with MP/postmolar GTN treated from March-December/2015-2020 were retrospectively evaluated and 528 of these patients answered a questionnaire. METHODS: Longitudinal retrospective multicentre study of patients diagnosed with MP/ postmolar GTN at presentation and a cross-sectional analysis, with application of a questionnaire, exclusive to patients treated during the period of study, to assess living and health conditions during the COVID-19 pandemic compared with previous years. MAIN OUTCOME MEASURES: The incidence of MP/postmolar GTN. RESULTS: Compared with the last 5 pre-pandemic years, MP/postmolar GTN incidence remained stable during 2020 (COVID-19 pandemic). Multivariable logistic regression, adjusted for the patient age, showed that during 2020, presentation with MP was more likely to be >10 weeks of gestation (adjusted odds ratio [aOR] 2.50, 95% confidence interval [CI] 1.90-3.29, P < 0.001), have a pre-evacuation hCG level ≥100 000 iu/l (aOR 1.77, 95% CI 1.38-2.28, P < 0.001) and time to the initiation of chemotherapy ≥7 months (aOR 1.86, 95% CI 1.01-3.43, P = 0.047) when compared with 2015-2019. CONCLUSIONS: Although the incidence of MP/postmolar GTN remained stable during the COVID-19 pandemic in Brazil, the pandemic was associated with greater gestational age at MP diagnosis and more protracted delays in initiation of chemotherapy for postmolar GTN.


Subject(s)
COVID-19 , Gestational Trophoblastic Disease , Hydatidiform Mole , Pregnancy , Female , Humans , Pandemics , Retrospective Studies , Cross-Sectional Studies , COVID-19/epidemiology , Hydatidiform Mole/epidemiology , Hydatidiform Mole/therapy , Gestational Trophoblastic Disease/epidemiology , Chorionic Gonadotropin
5.
BMC Musculoskelet Disord ; 23(1): 501, 2022 May 27.
Article in English | MEDLINE | ID: mdl-35624507

ABSTRACT

BACKGROUND: To describe success and failure (S&F) after lumbar spine surgery in terms equally understandable across the entire health ecosystem. METHODS: Back and leg pain and disability were prospectively recorded before and up to 12 months after the procedure. Satisfaction was recorded using a Likert scale. Initially, patients were classified as satisfied or unsatisfied. Optimal satisfaction/unsatisfaction cutoff values for disability and pain were estimated with ROC curves. Satisfied and unsatisfied groups underwent a second subdivision into four subcategories: success (satisfied AND pain and disability concordant with cutoff values), incomplete success (satisfied AND pain and disability nonconformant with cutoff values), incomplete failure (unsatisfied AND pain and disability nonconformant with cutoff values), and failure (unsatisfied AND pain and disability concordant with cutoff values). RESULTS: A total of 486 consecutive patients were recruited from 2019-2021. The mean values of preoperative PROMs were ODI 42.2 (+ 16.4), NPRS back 6.6 (+ 2.6) and NPRS leg 6.2 points (+ 2.9). Of the total, 80.7% were classified as satisfied, and 19.3% were classified as unsatisfactory. The optimal disability and pain cutoff values for satisfaction/unsatisfaction (NPRS = 6, AND ODI = 27) defined a subdivision: 59.6% were classified as success, 20.4% as incomplete success, 7.1% as incomplete failure and 12.4% as failure. The descriptions of each group were translated to the following: success-all patients were satisfied and presented no or only mild to tolerable pain and no or borderline disability; incomplete success - all patients were satisfied despite levels of pain and/or disability worse than ideal for success; incomplete failure - all patients were not satisfied despite levels of pain and/or disability better than expected for failure; failure - all patients were unsatisfied and presented moderate to severe pain and disability. CONCLUSION: It is possible to report S&F after surgery for DDL with precise and meaningful operational definitions focused on the experience of the patient.


Subject(s)
Ecosystem , Personal Satisfaction , Disability Evaluation , Humans , Pain , Pain Measurement/methods , Prospective Studies
6.
Trials ; 23(1): 445, 2022 May 26.
Article in English | MEDLINE | ID: mdl-35619152

ABSTRACT

BACKGROUND: Syphilis has recently resurfaced as a significant public health problem. Since the 2000s, isolated syphilis outbreaks have increasingly occurred in North America, Europe, and Australia; in Brazil, there have been progressive increases in both congenital and acquired syphilis. There are several possible explanations, such as misdiagnosis of acquired syphilis, which could increase the number of untreated transmitters in the population; failure to initiate or complete treatment; and nontreatment of sexual partners (leading to reinfection). Mobile technologies have been successfully used to promote behavior changes and can positively impact treatment and follow-up adherence in patients with infectious diseases. The purpose of this clinical trial is to evaluate treatment and monitoring methods in patients with syphilis, including follow-up by telephone, via a game in a smartphone app, and at public health centers. METHODS: The SIM study is a single-center, randomized controlled trial with a 12-month follow-up period. The aim is to identify the most effective method of follow-up regarding patient compliance with treatment. The tests will be performed in a mobile unit in easily accessible locations. The goal is to perform 10,000 rapid tests for syphilis. Patients with a confirmed diagnosis according to VDRL tests will be randomized to one of three arms: telephone, smartphone game, or conventional in-person follow-up. All analyses will follow the intention-to-treat principle. CONCLUSION: If we find differences in effectiveness, a major change in the conventional approach for this patient population may be needed, potentially affecting current Brazilian health policy strategies. TRIAL REGISTRATION: NTC04753125 . Version 1 of protocol 1/09/2020.


Subject(s)
Sexually Transmitted Diseases , Syphilis , Follow-Up Studies , Humans , Randomized Controlled Trials as Topic , Research , Sexual Partners , Sexually Transmitted Diseases/diagnosis , Sexually Transmitted Diseases/drug therapy , Sexually Transmitted Diseases/epidemiology , Syphilis/diagnosis , Syphilis/drug therapy , Syphilis/epidemiology
7.
J Public Health Policy ; 42(3): 359-372, 2021 Sep.
Article in English | MEDLINE | ID: mdl-34341478

ABSTRACT

We conducted a cross-sectional study to assess how the top 3 highest circulation newspapers from 25 countries are comparing and presenting COVID-19 epidemiological data to their readers. Of 75 newspapers evaluated, 51(68%) presented at their websites at least one comparison of cases and/or deaths between regions of their country and/or between countries. Quality assessment of the comparisons showed that only a minority of newspapers adjusted the data for population size in case comparisons between regions (37.2%) and between countries (25.6%), and the same was true for death comparisons between regions (27.3%) and between countries (27%). Of those making comparisons, only 13.7% explained the difference in the interpretation of cases and deaths. Of 17 that presented a logarithmic curve, only 29.4% explained its meaning. Although the press plays a key role in conveying correct medical information to the general public, we identified inconsistencies in the reporting of COVID-19 epidemiological data.


Subject(s)
COVID-19 , Global Health , Newspapers as Topic , COVID-19/epidemiology , Cross-Sectional Studies , Global Health/statistics & numerical data , Humans , Newspapers as Topic/standards , Newspapers as Topic/statistics & numerical data
8.
Sci Rep ; 11(1): 15367, 2021 07 28.
Article in English | MEDLINE | ID: mdl-34321555

ABSTRACT

Human T-lymphotropic virus type 1 (HTLV-1) infection may cause serious disease, while pathogenicity of HTLV-2 is less certain. There are no screening or surveillance programs for HTLV-1/-2 infection in Brazil. By performing this systematic review, we aimed to estimate the prevalence of HTLV-1/-2 infections in pregnant women in Brazil. This review included cohort and cross-sectional studies that assessed the presence of either HTLV-1/-2 infection in pregnant women in Brazil. We searched BVS/LILACS, Cochrane Library/CENTRAL, EMBASE, PubMed/MEDLINE, Scopus, Web of Science and gray literature from inception to August 2020. We identified 246 records in total. Twenty-six of those were included in the qualitative synthesis, while 17 of them were included in the meta-analysis. The prevalence of HTLV-1 in Brazilian pregnant women, as diagnosed by a positive screening test and a subsequent positive confirmatory test, was 0.32% (95% CI 0.19-1.54), while of HTLV-2 was 0.04% (95% CI 0.02-0.08). Subgroup analysis by region showed the highest prevalence in the Northeast region (0.60%; 95% CI 0.37-0.97) for HTLV-1 and in the South region (0.16%; 95% CI 0.02-1.10) for HTLV-2. The prevalence of HTLV-1 is much higher than HTLV-2 infection in pregnant Brazilian women with important differences between regions. The prevalence of both HTLV-1/-2 are higher in the Northeast compared to Center-West region.


Subject(s)
HTLV-I Infections/epidemiology , HTLV-II Infections/epidemiology , Human T-lymphotropic virus 1/pathogenicity , Human T-lymphotropic virus 2/pathogenicity , Brazil/epidemiology , Female , HTLV-I Infections/pathology , HTLV-I Infections/virology , HTLV-II Infections/pathology , HTLV-II Infections/virology , Humans , Pregnancy , Pregnant Women
9.
Br J Nutr ; 126(7): 1048-1055, 2021 10 14.
Article in English | MEDLINE | ID: mdl-33292886

ABSTRACT

This randomised clinical trial aimed to evaluate the effect of a pro-breast-feeding (BF) and healthy complementary feeding intervention performed during infants' first months of life on ultraprocessed food (UPF) consumption at 4-7 years. We enrolled 323 teenage mothers and their infants from South Brazil, 163 allocated to the intervention group and 160 to the control group. Intervention consisted of sessions on BF and healthy complementary feeding promotion and was carried out in the maternity ward and at home after delivery. Food consumption was assessed using three 24-h food recalls at child's age of 4-7 years. Foods were classified according to NOVA classification. Dietary contribution of UPF was adjusted for intra-individual variability by the SPADE method and categorised into tertiles. We used Poisson regression models with robust variance, adjusted for confounders, to estimate the effect of the intervention and duration of BF on the risk of high consumption of UPF. Our final analysis included 194 children, with mean age of 6·1 (sd 0·5) years. Mean dietary contribution of UPF was 38 % in the intervention group and 42·7 % in the control group, from total daily intakes. Results adjusted for BF duration, propensity score, income and total energy content demonstrated that the intervention reduced the risk of high consumption of UPF by 35 % (relative risk 0·65, 95 % CI 0·43, 0·98). BF duration was not associated with UPF consumption. The intervention was effective in reducing the risk of high UPF consumption at the age of 4-7 years.


Subject(s)
Adolescent Mothers , Diet, Healthy , Adolescent , Brazil , Breast Feeding , Child , Child, Preschool , Diet , Fast Foods , Female , Humans , Infant , Infant Nutritional Physiological Phenomena , Male , Pregnancy
10.
Rev. psicol. organ. trab ; 20(3): 1080-1088, jul.-set. 2020. ilus
Article in Portuguese | LILACS-Express | LILACS, Index Psychology - journals | ID: biblio-1127182

ABSTRACT

O objetivo deste estudo foi avaliar o nível de engajamento e de adição ao trabalho e suas correlações com recursos pessoais, recursos do trabalho e demandas no trabalho em profissionais de Recursos Humanos (RH). Participaram 440 profissionais, 80% do sexo feminino, das cinco regiões brasileiras. Os resultados sugerem que os profissionais de RH têm engajamento mediano, compatível com autoestima, otimismo, autoeficácia e esperança. Também apresentam nível de adição laboral médio, de modo que os achados demonstram que o trabalho excessivo e trabalho compulsivo é uma realidade da prática deles. Para a faixa etária acima dos 40 anos, o nível de engajamento demonstrou ser médio-inferior, algo contrário às expectativas para esta fase solidificação de carreira. Ademais, foi encontrada correlação positiva e fraca com a adição ao trabalho, o que sugere a influência do trabalho excessivo e compulsivo no modo de ativação de energia. Apresentamos sugestões de estudos futuros para avanços na área.


The main goal of this study was to evaluate the level of engagement and workaholism and its correlations with personal resources, job resources and job demands in Human Resources professionals. In this study, 440 HR professionals participated, being 80% women from Brazil's five region. The findings suggest that HR professionals show an average level of engagement with the work they do, which is compatible with self-esteem, optimism, self-efficacy and hope. Besides, they also show an average level of workaholism, which demonstrates that excessive and compulsive work is something real in their everyday routine. People over 40 years old showing a lower average level of engagement, which was unexpected since this age group is supposed to be solid careers. Moreover, a positive and weak correlation with workaholism was found, which suggests the influence of excessive and compulsive work at the way energy is activated. Suggestions are presented for further studies in the area.


El principal objetivo de este estudio fue el de evaluar el nivel de compromiso y de adicción al trabajo y sus correlaciones con recursos personales, recursos laborales y demandas en el trabajo en profesionales de recursos humanos. Participaron 440 profesionales, 80% sexo femenino, de las cinco regiones de Brasil. Los hallazgos sugieren que los profesionales de RH mostraron un nivel promedio de compromiso, compatible con autoestima, optimismo, autoeficacia y esperanza. También mostraron un nivel de adicción laboral promedio, lo que demuestra que el trabajo excesivo y compulsivo es una realidad en su rutina diaria. Para el grupo de edad superior a los 40 años, el nivel de compromiso demostró ser inferior en promedio algo contrario a las expectativas para esta fase solidificación de carrera. Además, se encontró una positiva y débil correlación con la adicción al trabajo, lo que sugiere la influencia del trabajo excesivo y compulsivo a la vez que es activada la energía. Se presentan sugerencias para estudios futuros en el área.

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