ABSTRACT
BACKGROUND: the purpose of this study was to investigate the presence of respiratory allergy in 30 Mexican patients bearing cystic fibrosis (CF). METHODS AND RESULTS: all patients completed a clinical history, had a physical examination, total serum IgE, nasal and blood eosinophils determinations and evaluation of skin prick tests for 36 allergens. In 26.6% of the patients included in the study was detected respiratory allergy diagnosed on clinical and laboratory analyses. Skin prick tests of 11 (36.6%) of the patients were positive to at least one allergen and Aspergillus fumigatus (A. fumigatus) was the most frequently observed allergen in 23% of the cases. CONCLUSIONS: we have demonstrated in this study that Mexican patients also present a coexistence of respiratory allergy in patients bearing CF.
Subject(s)
Cystic Fibrosis/complications , Respiratory Hypersensitivity/complications , Adult , Aspergillus fumigatus/immunology , Child, Preschool , Cystic Fibrosis/immunology , Female , Humans , Immunoglobulin E/blood , Infant , Male , Mexico , Respiratory Hypersensitivity/immunology , Skin TestsABSTRACT
Thymus hyperplasia is not a rare condition in infancy, but it is generally considered not to cause any symptoms. We present here a series of 11 children seen at the National Institute of Pediatrics (NIP), Mexico-city, that do have respiratory symptoms secondary to the enlarged gland. Age of onset of the symptoms was median at birth, with age of first visit to the NIP of 6 months. Symptoms were respiratory crisis and various respiratory complaints. Five underwent thoracotomy and resection of the right pulmonary lobe was necessary in one, because of irreversible changes in the lung tissue due to chronic compression. In another patient thymic lobectomy was executed because extrinsic compression of the right upper bronchus resulted in recurrent atelectasia. The five biopsies taken during the intervention showed normal or hyperplastic or involutive thymic tissue without signs of malignancy. The evolution was positive in all the patients. In conclusion thymic hyperplasia must be taken into account in the evaluation of an infant with respiratory symptoms.
Subject(s)
Airway Obstruction/diagnosis , Respiratory Sounds/etiology , Thymus Gland/pathology , Adolescent , Airway Obstruction/diagnostic imaging , Airway Obstruction/etiology , Asthma/diagnosis , Biopsy , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Hyperplasia , Infant , Infant, Newborn , Male , Mediastinal Neoplasms/diagnosis , Pulmonary Atelectasis/etiology , Radiography , Thymus Gland/diagnostic imagingABSTRACT
This article review the effects of neuropeptides in the pathogenesis of Asthma. It is a review of literature and show most important neuropeptides, physical and chemical characteristics effects and some clinical studies about them.
Subject(s)
Asthma/etiology , Asthma/physiopathology , Neuropeptides/physiology , Autonomic Nervous System/physiopathology , Calcitonin Gene-Related Peptide/physiology , Humans , Neuropeptide Y/physiology , Peptide PHI/physiology , Substance P/physiology , Vasoactive Intestinal Peptide/physiologyABSTRACT
We studied 40 children with one o more perennial allergic diseases (bronchial asthma, allergic rhinitis, and/or atopic dermatitis) to assess the value in our country of in vivo and in vitro tests more frequently used in the diagnosis of allergy, such as total serum IgE, specific allergen IgE (RAST) and prick skin test in patients sensitives to D. pteronissinus, D. farinae or both. All patients had positive prick skin tests. Total serous IgE was elevated in 95% of cases with poor correlation coefficient (r) between prick skin test reactivity and total serous IgE concentration with no statistical significance. On the other hand, 95% of patients showed a positive RAST with a correlation coefficient of 0.31 (p less than 0.05). We concluded that in our country clinical history and prick skin tests are sufficiently accurate in a reasonable way to make a diagnosis of allergic etiology in patients sensitives to mites of the house dust.