ABSTRACT
A 45-year-old white male, 35-year status postrepair of coarctation of the aorta, presented with symptomatic recoarctation of the aorta. He was treated successfully by implantation of a single Palmaz stent. The pressure gradient was abolished with complete resolution of symptoms. Seven months poststent implant, angiography revealed good lumen diameter and a small pressure gradient. Over an 18-mo follow-up period, there has been no recurrence of symptoms. Primary stenting may have a significant role in the treatment of patients with symptomatic recoarctation of the aorta.
Subject(s)
Angioplasty, Balloon/instrumentation , Aortic Coarctation/therapy , Stents , Angiography , Angioplasty, Balloon/methods , Aorta, Thoracic/diagnostic imaging , Aortic Coarctation/diagnosis , Aortic Coarctation/physiopathology , Cardiac Catheterization , Echocardiography, Transesophageal , Follow-Up Studies , Hemodynamics/physiology , Humans , Male , Middle Aged , Recurrence , Vascular PatencyABSTRACT
The intrathecal production of antimeasles antibodies was studied using the enzyme-linked immunosorbent assay in eight specimens of serum and cerebrospinal fluid (CSF) from patients with clinical signs of subacute sclerosing panencephalitis (SSPE). The test was performed using a 1:5 dilution of CSF and a 1:2000 dilution of serum (ratio 1:400) in order to nullify the physiological gradient of immunoglobulins across the blood brain barrier (BBB). This procedure allowed a rapid and accurate assessment of the synthesis of specific immunoglobulins in the CSF and a good evaluation of the permeability of the BBB. A diagnosis of SSPE was provided in five out of eight patients with clinical signs of the disease. Clinical follow-up confirmed the diagnosis of SSPE in the group of patients with clear evidence of intrathecal synthesis of antimeasles antibodies.
Subject(s)
Antibodies, Viral/cerebrospinal fluid , Immunoglobulin G/cerebrospinal fluid , Immunoglobulin M/cerebrospinal fluid , Measles virus/immunology , Subacute Sclerosing Panencephalitis/cerebrospinal fluid , Adolescent , Adult , Antibodies, Viral/biosynthesis , Antibodies, Viral/immunology , Blood-Brain Barrier , Child , Cytomegalovirus/immunology , Enzyme-Linked Immunosorbent Assay , Female , Herpesvirus 3, Human/immunology , Humans , Male , Mumps virus/immunology , Rubella virus/immunology , Serologic Tests , Simplexvirus/immunology , Subacute Sclerosing Panencephalitis/immunologySubject(s)
Bone Marrow Transplantation , Leukemia/therapy , Adolescent , Adult , Antineoplastic Agents/therapeutic use , Child , Female , Humans , Male , Middle AgedSubject(s)
Cystitis/microbiology , Enterobacteriaceae/growth & development , Menstruation , Vagina/microbiology , Estrogens/blood , Female , Humans , RecurrenceABSTRACT
9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.
