ABSTRACT
A method for the fast and reliable evaluation of the sedative and/or antidepressant activity of drugs has been tested. The drugs were administered in very small quantities directly on the cortex of conscious rabbits, and spectrum analysis of the electro-corticogram, recorded from the place of administration, was used to evaluate the potency of the drug. A quantitisation of the obtained results has been elaborated.
Subject(s)
Electroencephalography/methods , Psychotropic Drugs/pharmacology , Animals , Cerebral Cortex/drug effects , Computers , Drug Evaluation, Preclinical/methods , Fourier Analysis , Pain/physiopathology , RabbitsABSTRACT
The action of neuromuscular blocking agents on the spontaneous sympathetic activity has been quantitated. "On line" spectrum analysis has been applied to the action potential of pre- and post ganglionic nerves of the coeliac plexus. The activity, the frequency spectrum and their changes after the injection of clinical and high doses of decamethonium, D-tubocurarine, succinylcholine, gallamine and pancuronium are determined.
