ABSTRACT
An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.
Subject(s)
Antiviral Agents , Herpesvirus 1, Human/drug effects , Porphyrins , Vinyl Compounds , Animals , Antiviral Agents/chemical synthesis , Antiviral Agents/pharmacology , Antiviral Agents/radiation effects , Cations/chemistry , Cell Proliferation/drug effects , Chlorocebus aethiops , Dose-Response Relationship, Drug , Drug Design , Microbial Sensitivity Tests , Molecular Structure , Photochemistry , Porphyrins/chemical synthesis , Porphyrins/pharmacology , Porphyrins/radiation effects , Structure-Activity Relationship , Ultraviolet Rays , Vero Cells , Vinyl Compounds/chemical synthesis , Vinyl Compounds/pharmacology , Vinyl Compounds/radiation effectsABSTRACT
Studies on the synthesis, structural elucidation, and antiviral evaluation of several carbohydrate-substituted meso-tetraarylporphyrins against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are described. The potential of those photosensitizers, and of their precursors, on the photoinactivation of HSV-1 and HSV-2 was examined in Vero cells. Their virucidal and viral replication effects were assessed under white light, at their maximum noncytotoxic concentrations. The highest inhibitory effects on viral replication, for both viruses, were obtained with the glycoporphyrins where the sugar moiety bears unprotected hydroxyl groups. Strong inhibition of virus yield was observed even at concentrations much lower than their maximum noncytotoxic concentrations. These compounds can be postulated to be useful as potential drugs for the treatment of herpes simplex viruses infections.
