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Treatment with tigecycline of recurrent urosepsis caused by extended-spectrum-beta-lactamase-producing Escherichia coli.

Krueger, Wolfgang A; Kempf, Volkhard A J; Peiffer, Manou; Nagele, Udo; Unertl, Klaus E; Schroeder, Torsten H.

J Clin Microbiol ; 46(2): 817-20, 2008 Feb.

Article in English | MEDLINE | ID: mdl-18077630

ABSTRACT

A 25-year-old female was admitted to our intensive care unit with septic shock and multiorgan failure caused by extended-spectrum beta-lactamase-producing Escherichia coli originating from the right renal pelvis. A 16-day course of treatment with meropenem reversed the septic condition, but the infection recurred thereafter. The patient recovered fully after therapy was changed to tigecycline.

Subject(s)

Anti-Bacterial Agents/therapeutic use , Escherichia coli Infections/drug therapy , Escherichia coli/drug effects , Minocycline/analogs & derivatives , Shock, Septic/drug therapy , Urinary Tract Infections/drug therapy , beta-Lactam Resistance , Adult , Escherichia coli/isolation & purification , Escherichia coli Infections/microbiology , Female , Humans , Meropenem , Minocycline/therapeutic use , Recurrence , Shock, Septic/microbiology , Thienamycins/therapeutic use , Tigecycline , Urinary Tract Infections/complications , Urinary Tract Infections/microbiology , beta-Lactamases/biosynthesis

ABSTRACT

Subject(s)

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