Influence of intraoral application of antiseptics and fluorides during orthodontic treatment on corrosion and mechanical characteristics of nickel-titanium alloy in orthodontic appliances.

OBJECTIVES: To explore whether the commercial agents recommended for controlling dental biofilm formation had a significant effect in vivo on mechanical and corrosion properties of nickel-titanium (NiTi) alloy. MATERIALS AND METHODS: NiTi archwires (dimensions 0.508 × 0.508 mm) were collected from 36 orthodontic patients aged 13-42 years after a 3-month intraoral exposure. Three experimental groups were formed: (1) subjects conducting regular oral hygiene, (2) subjects who used fluorides for intensive prophylaxis for the first month, and (3) subjects who used chlorhexidine in the same manner. Corrosion behavior, surface characteristics, stiffness, hardness, and friction were analyzed. RESULTS: Exposure to intraoral conditions significantly reduced the stiffness and hardness of the NiTi alloy (P ≤ .015). Fluoride tended to reduce stiffness and hardness more than did saliva or antiseptic, but not significantly. Roughness and friction were not significantly influenced by oral exposure. Intraoral aging predominantly produced general corrosion independent of the adjuvant prophylactic agent, although localized corrosion may also have occurred. CONCLUSIONS: Fluorides and the antiseptic chlorhexidine do not increase corrosion more than saliva itself, nor do they further modify the mechanical properties of the NiTi alloy.

Effects of the presence of probiotic bacteria in the aging medium on the surface roughness and chemical composition of two dental alloys.

The aims of this study were: (a) to determine if the presence of probiotic bacteria in an aging medium, that is, artificial saliva in this study, has relevant effects on the surface roughness and the chemical composition of two main alloys used in dentistry (NiTi and stainless steel [SS]) and (b) in the case of NiTi, if these effects are influenced by the coating of the alloy (rhodium and titanium nitride). Atomic force microscopy and Raman spectroscopy were used to study the surface morphology and identify metal oxides formed on the surface of the alloys. Experiments demonstrated that the probiotic bacteria Lactobacillus reuteri can induce processes that alter some features of the surface such as roughness and chemical composition. The effect is dependent on the type of alloy and coating. The bacteria increased roughness in the case of uncoated NiTi more than saliva alone (pH = 4.8). Probiotic bacteria tend to decrease the corrosive influence of saliva on NiTi when the alloy is coated with rhodium or titanium nitride and this effect was also evidenced on SS. Raman spectroscopy confirmed that only SS samples are prone to oxidation processes, predominantly associated with exposure to saliva rather than probiotic bacteria.

PEO-PPO-PEO/Poly(DL-lactide-co-caprolactone) Nanoparticles as Carriers for SN-38: Design, Optimization and Nano-Bio Interface Interactions.

Encapsulation of extremely hydrophobic substances such as SN-38 into nanoparticles, is a promising approach to solve the solubility issue and enable drug administration. Moreover, nanocarriers' tumor homing behavior, targeted and controlled release at the site of action will optimize therapeutic potency and decrease toxicity of the incorporated drug substance. However, the enormous drug hydrophobicity might limit the capacity for encapsulation as the premature drug precipitation will contribute to fast free drug crystal growth, low drug incorporation and huge waste of the active material. In this article we defined the optimal region for manufacturing of SN-38 loaded PEO-PPO-PEO/P(DL)LCL nanoparticles (NPs) with high efficacy of encapsulation, suitable particle size and different surface properties, using D-optimal design and nanoprecipitation as production method. Further we made an approach to investigate the interactions with macromolecules at the nano-bio interface which are predetermined by the physico-chemical and surface properties of the NPs, and are important determinants for the biological identity of the nanoparticles, the potential for evasion of the physiological barriers and the efficacy of localization at the site of action. Here we present in depth analysis of the behavior of two types of nanoparticles with different surface properties through structured protein interaction and bioreactivity experiments in order to presuppose NP performance and toxicological profile in biological environment.