[Evaluation of hearing in children with solid tumors treated by chemotherapy]. / Ocena sluchu u dzieci z guzami litymi w trakcie chemioterapii.

Ototoxicity of cisplatin is documented in during the last years. In material of 13 children with solid tumors (neuroblastoma, nephroblastoma, rhabdomyoscarcoma) treated with cisplatin, ototoxicity was observed in 2 cases. There were presented audiological findings. The role of otoacoustic emission measurements in monitoring of cisplatin--induced ototoxicity was underlined.

[The use of hematopoietic growth factors G-CSF/GM-CSF in the treatment of neutropenia in children with acute lymphoblastic leukemia and non-Hodgkin's lymphomas]. / Zastosowanie krwiotwórczych czynników wzrostu granulocytów i makrofagów w leczeniu neutropenii u dzieci z ostra bialaczka limfoblastyczna i nieziarniczymi chloniakami zlosliwymi.

Maximal intensification of antineoplastic therapy is currently a predominant trend in the treatment regimens for acute leukemias and lymphomas. However, by such approach myelosuppression and counteracting its sequelae become paramount problems. Hematopoietic growth factors G-CSF/GM-CSF play a great role in this aspect of the therapy. Effects of 35 courses of G-CSF/GM-CSF were evaluated in 19 children with ALL and NHL and compared with 21 episodes of neutropenia in 15 historical controls. In the treatment group time of neutropenia was approx. 3 times shorter as compared with a control group. Fever accompanying neutropenia occurred less frequently and lasted shorter in the treatment group. Also, symptoms of infection subsided faster. Subjective life quality was better in children receiving growth factors.