ABSTRACT
The authors evaluated influence of Alfetin new Russian biologic preparation on pulmonary surfactant system and phospholipid metabolism in workers at risk of occupational pneumoconiosis, who suffer from infiltrative pulmonary tuberculosis. Considering positive changes in serum phospholipids subunits under alfetin treatment, the authors proved membrane protective effect of the drug. Alfetin was proved to weaken toxic effects of tuberculostatic drugs on lung surfactant.
Subject(s)
Occupational Diseases/drug therapy , Tuberculosis, Pulmonary/drug therapy , alpha-Fetoproteins/therapeutic use , Adult , Double-Blind Method , Humans , Injections, Intravenous , Male , Middle Aged , Occupational Diseases/metabolism , Phospholipids/blood , Pulmonary Surfactants/metabolism , Treatment Outcome , Tuberculosis, Pulmonary/metabolism , alpha-Fetoproteins/administration & dosageABSTRACT
The relationship between the efficiency of treatment and the nature of morphological changes in the lung was studied in 125 patients with pulmonary tuberculosis without X-ray signs of pneumoconiosis who worked at coniosis-risk enterprises (CRR). Despite adequate specific and pathogenetic therapy, tuberculomas formed and decay cavities preserved in the patients, in this connection they had surgical treatment. Three types of morphological changes were identified. Quartz-containing industrial dust was found to exert an adverse potentiating effect on the course of tuberculosis in most CRE patients: increases in the delimiting a specific process of respiratory disorders and postoperative complications. These specific features should be borne in mind in drawing up a treatment protocol for patients working exposed to industrial dust.
Subject(s)
Lung/pathology , Occupational Exposure/adverse effects , Silicosis/pathology , Tuberculosis, Pulmonary/pathology , Adult , Humans , Lung/surgery , Radiography , Silicosis/complications , Silicosis/diagnostic imaging , Silicosis/surgery , Silicotuberculosis/pathology , Silicotuberculosis/surgery , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/surgeryABSTRACT
The authors have substantiated and studied the use of lymphotropic (interstitial) injection of 1% isoniazid solution in the complex therapy of patients with pulmonary tuberculosis. The method provides active interstitial functioning of the diseased organ. This leads to a substantial improvement of immediate results of treatment in patients as accelerated closure of decay cavities and double cessation of bacterial isolation.
