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1.
J Contin Educ Health Prof ; 21(4): 238-46, 2001.
Article in English | MEDLINE | ID: mdl-11803768

ABSTRACT

Recent events in genetics research have generated questions about the efficacy of federal regulations that govern the conduct of biomedical research, particularly genetics research. The regulatory definitions of "human subject" and "private information" that have governed the conduct of research for two decades are presently under scrutiny because of ambiguities created by the methods of family studies in human and medical genetics. Geneticists customarily collect family history information for the purposes of tracking and characterizing genes in large families. Amassing family history information usually entails asking human subjects about the health status of collateral relatives. Whether these relatives should be regarded as human subjects for the purposes of giving informed consent is the issue that has triggered wide debate and an exhaustive re-examination of federal regulations and guidelines. The purpose of this article is threefold. First, a review of the development of current federal regulations provides a foundation and a point of departure for resolving current issues in genetics research. Second, a review of customary practices in genetics research furthers thought regarding regulations or guidelines to address specific issues in genetics. Third, it asserts that any new regulations or guidelines must provide appropriate protections for human subjects and their families while simultaneously supporting appropriate activities in genetics research.


Subject(s)
Facility Regulation and Control/legislation & jurisprudence , Genetic Privacy/legislation & jurisprudence , Pedigree , Research/standards , Bioethics , Guidelines as Topic , Human Experimentation/legislation & jurisprudence , Humans , Informed Consent , Medical History Taking , Research/legislation & jurisprudence , United States
6.
Biochim Biophys Acta ; 1407(1): 84-91, 1998 Jul 01.
Article in English | MEDLINE | ID: mdl-9639681

ABSTRACT

Usher syndrome type 1C (USH1C) occurs in a small population of Acadian descendants from southwestern Louisiana. Linkage and linkage disequilibrium analyses localize USH1C to chromosome 11p between markers D11S1397 and D11S1888, an interval of less than 680 kb. Here, we refine the USH1C linkage to a region less than 400 kb, between genetic markers D11S1397 and D11S1890. Using 17 genetic markers from this interval, we have isolated a contiguous set of 60 bacterial artificial chromosomes (BACs) that span the USH1C critical region. Exon trapping of BAC clones from this region resulted in the recovery of an exon of the nuclear EF-hand acidic (NEFA) gene. However, DNA sequence analysis of the NEFA cDNA from lymphocytes of affected individuals provided no evidence of mutation, making structural mutations in the NEFA protein unlikely as the cellular cause of Acadian Usher syndrome.


Subject(s)
Chromosome Mapping , Chromosomes, Human, Pair 11 , DNA-Binding Proteins/genetics , Hearing Loss, Sensorineural/genetics , Retinitis Pigmentosa/genetics , Bacteriophage P1/genetics , Calcium-Binding Proteins , Canada/ethnology , Chromosomes, Artificial, Yeast , Cloning, Molecular , France/ethnology , Hearing Loss, Sensorineural/classification , Hearing Loss, Sensorineural/epidemiology , Humans , Louisiana/epidemiology , Microsatellite Repeats , Nerve Tissue Proteins , Nucleobindins , Retinitis Pigmentosa/classification , Retinitis Pigmentosa/epidemiology , Sequence Analysis, DNA , Syndrome
8.
Am J Hum Genet ; 60(6): 1265-75, 1997 Jun.
Article in English | MEDLINE | ID: mdl-9199545

ABSTRACT

The field of behavioral genetics has enormous potential to uncover both genetic and environmental influences on normal and deviant behavior. Behavioral-genetic methods are based on a solid foundation of theories and methods that successfully have delineated components of complex traits in plants and animals. New resources are now available to dissect the genetic component of these complex traits. As specific genes are identified, we can begin to explore how these interact with environmental factors in development. How we interpret such findings, how we ask new questions, how we celebrate the knowledge, and how we use or misuse this knowledge are all important considerations. These issues are pervasive in all areas of human research, and they are especially salient in human behavioral genetics.


Subject(s)
Behavioral Research , Genetic Research , Genetics, Behavioral , Genetics, Medical , Adoption , Bioethics , Biometry , Family , Female , Genetic Counseling , Genetics, Behavioral/trends , Genetics, Medical/trends , Humans , Male , Models, Genetic , Twin Studies as Topic
11.
Mol Vis ; 1: 2, 1995 Oct 25.
Article in English | MEDLINE | ID: mdl-9238080

ABSTRACT

PURPOSE: To refine the map position of the Usher syndrome type 1C (USH1C) locus to 11p14-p15.1 in the French-Acadian population settled in Louisiana. METHODS: Linkage and haplotype analysis of Ush1C in the French-Acadian families from southwestern Louisiana was carried out using additional markers known to map to the USH1C interval. Markers localized to 11p were also mapped on the J1 somatic cell hybrid panel. This analysis also helped to localize precisely the USH1C interval. RESULTS: New flanking markers for USH1C have been identified, localizing the USH1C gene to a 1 cM interval between markers D11S1397 and D11S1888. Markers D11S1890 and D11S1888 were placed within the USH1C interval. Analysis of all the markers in the USH1C region flanked by D11S1397 and D11S1888 on the J1 somatic cell hybrid panel localized USH1C to the upper half of chromosome 11p14. CONCLUSION: The Usher Syndrome type 1C gene has been localized to a 1 cM interval between the markers D11S1397 and D11S1888 on chromosome 11p14.


Subject(s)
Chromosomes, Human, Pair 11 , Hearing Loss, Sensorineural/genetics , Retinitis Pigmentosa/genetics , Canada/ethnology , Chromosome Mapping , France/ethnology , Haplotypes , Humans , Louisiana , Microsatellite Repeats/genetics , Syndrome
12.
Am J Hum Genet ; 54(4): 681-6, 1994 Apr.
Article in English | MEDLINE | ID: mdl-8128966

ABSTRACT

Usher syndrome type I is an autosomal recessive disease characterized by profound congenital hearing impairment and vestibular dysfunction followed by the onset of progressive pigmentary retinopathy in childhood or early adolescence. A locus (USH1C) for one form of this disease was previously assigned to the short arm of chromosome 11 through linkage studies in the Acadian population of southwestern Louisiana. Linkage analyses of a set of microsatellite markers in 27 Acadian families provide evidence that USH1C lies between D11S861 and D11S928. Three markers (D11S419, D11S921, and D11S899) that lie between the flanking markers show no recombination with USH1C, and all 54 chromosomes with the abnormal allele at the disease locus have identical alleles for D11S419 and D11S921. This haplotype was found on only 10 of 50 chromosomes with the normal allele at the disease locus, suggesting a strong founder effect. Of the 54 chromosomes with the abnormal allele, 12 had a divergent allele at D11S899. These results suggest that USH1C is in the 2-3-cM interval between D11S861 and D11S899.


Subject(s)
Chromosomes, Human, Pair 11 , Deafness/genetics , Genetics, Population , Retinitis Pigmentosa/genetics , DNA, Satellite/analysis , Deafness/congenital , Genetic Linkage , Genetic Markers , Haplotypes , Humans , Lod Score , Louisiana , Pedigree , Quebec/ethnology , Syndrome
13.
Am J Med Genet ; 50(1): 32-8, 1994 Mar 01.
Article in English | MEDLINE | ID: mdl-8160750

ABSTRACT

The Usher syndromes are genetically distinct disorders which share specific phenotypic characteristics. This paper describes a set of clinical criteria recommended for the diagnosis of Usher syndrome type I and Usher syndrome type II. These criteria have been adopted by the Usher Syndrome Consortium and are used in studies reported by members of this Consortium.


Subject(s)
Hearing Loss, Sensorineural/congenital , Hearing Loss, Sensorineural/diagnosis , Retinitis Pigmentosa/diagnosis , Vestibular Diseases/diagnosis , Diagnosis, Differential , Electroretinography , Hearing Loss, Sensorineural/genetics , Humans , Ophthalmoscopy , Retinitis Pigmentosa/genetics , Surveys and Questionnaires , Syndrome , Vestibular Diseases/genetics , Vestibular Function Tests
15.
Genomics ; 14(4): 995-1002, 1992 Dec.
Article in English | MEDLINE | ID: mdl-1478678

ABSTRACT

The Usher syndromes (USH) are autosomal recessive diseases characterized by congenital sensorineural hearing loss and progressive pigmentary retinopathy. While relatively rare in the general population, collectively they account for approximately 6% of the congenitally deaf population. Usher syndrome type II (USH2) has been mapped to chromosome 1q (W. J. Kimberling, M. D. Weston, C. Möller, et al., 1990, Genomics 7: 245-249; R. A. Lewis, B. Otterud, D. Stauffer, et al., 1990, Genomics 7: 250-256), and one form of Usher syndrome type I (USH1) has been mapped to chromosome 14q (J. Kaplan, S. Gerber, D. Bonneau, J. Rozet, M. Briord, J. Dufier, A. Munnich, and J. Frezal, 1990. Cytogenet. Cell Genet. 58: 1988). These loci have been excluded as regions of USH genes in our data set, which is composed of 8 French-Acadian USH1 families and 11 British USH1 families. Both of these sets of families show linkage to loci on chromosome 11. Linkage analysis demonstrates locus heterogeneity between these sets of families, with the French-Acadian families showing linkage to D11S419 (Z = 4.20, theta = 0) and the British families showing linkage to D11S527 (Z = 6.03, theta = 0). Genetic heterogeneity of the data set was confirmed using HOMOG and the M test (log likelihood ratio > 10(5)). These results confirm the presence of two distinct USH1 loci on chromosome 11.


Subject(s)
Chromosomes, Human, Pair 11 , Hearing Disorders/genetics , Retinitis Pigmentosa/genetics , Chromosome Mapping , Female , Genetic Linkage , Hearing Disorders/congenital , Humans , Lod Score , Male , Pedigree , Polymorphism, Genetic , Syndrome
16.
Genomics ; 14(3): 707-14, 1992 Nov.
Article in English | MEDLINE | ID: mdl-1427898

ABSTRACT

Usher Syndrome Type 1 is an autosomal recessive disease characterized by profound congenital hearing impairement and vestibular dysfunction followed by the onset of retinitis pigmentosa in childhood or early adolescence. Members of the Usher Syndrome Consortium, whose objective is to locate and isolate the genes for Usher syndrome, have pooled linkage data from 36 families with 111 affected individuals. We report the analysis of 206 blood group, protein, and DNA marker polymorphisms. No evidence of linkage heterogeneity among families was found for any of the markers studied; the negative lod scores exclude the locus for this disease from about 39% of the genome. Our results indicate the regions of the genome to which our continuing efforts should be directed.


Subject(s)
Deafness/genetics , Genetic Linkage , Retinitis Pigmentosa/genetics , Chromosome Mapping , Chromosomes, Human , Genes, Recessive , Genetic Markers , Humans , Syndrome
17.
Am J Med Genet ; 43(6): 964-9, 1992 Aug 01.
Article in English | MEDLINE | ID: mdl-1415347

ABSTRACT

A number of Usher syndrome (USH) families are found among the French-Acadians living in southwestern Louisiana. These families are descended from a few common ancestors, suggesting that USH may be homogeneous within this ethnic group. However, we report distinct phenotypic variability. Based on differences in psychomotor development and tests of auditory and vestibular function, Acadian individuals with both USH Type 1 and Type 2 can be identified. One additional family, with unusual findings, represents a third clinical phenotype. Linkage data strongly support these clinical observations.


Subject(s)
Blindness/genetics , Hearing Disorders/genetics , Chromosomes, Human, Pair 1 , Ethnicity , Female , Genetic Markers , Hearing Disorders/classification , Humans , Louisiana , Male , Pedigree , Phenotype , Syndrome
18.
Am J Med Genet ; 39(3): 347-54, 1991 Jun 01.
Article in English | MEDLINE | ID: mdl-1867289

ABSTRACT

As technical knowledge and public information in medical genetics continue to expand, the geneticist may expect to be held responsible for informing patients and clients about new developments in research and diagnosis. The long legal evolution of the physician's duty to disclose, and more recent findings of a physician's duty to recall former patients to inform them about newly discovered risks of treatment, indicate that medical geneticists may have a duty to disclose both current and future information about conditions that are or could be inherited. Recent case law supports findings of professional liability for both present and future disclosure, even in the absence of an active physician-patient relationship. The requirement of candid and complete disclosure will affect the counseling approach in testing for deleterious genes and in providing medical treatment for minors with hereditary diseases. Finding a duty to recall may impose further professional burdens on the geneticist to reach beyond the immediate counseling arena and to recontact patients, perhaps years after their initial visit to genetics clinic.


Subject(s)
Disclosure , Genetics, Medical/legislation & jurisprudence , Truth Disclosure , Beneficence , Child , Genetic Counseling/legislation & jurisprudence , Genetic Diseases, Inborn/therapy , History, 20th Century , Humans , Informed Consent/history , Informed Consent/legislation & jurisprudence , Liability, Legal , Malpractice , Minors , Morals , Parental Consent , Personal Autonomy , Physician-Patient Relations , Risk Assessment
19.
Am J Med Genet ; 37(4): 447-50, 1990 Dec.
Article in English | MEDLINE | ID: mdl-2260585

ABSTRACT

We report on a patient with craniosynostosis, left radius aplasia, right radius hypoplasia, and other congenital anomalies. This is the 11th reported case of the Baller-Gerold syndrome. Autosomal recessive inheritance of this syndrome is suggested by evidence of probable parental consanguinity.


Subject(s)
Abnormalities, Multiple , Craniosynostoses , Radius/abnormalities , Child , Consanguinity , Female , Genes, Recessive , Growth Disorders , Humans , Intellectual Disability , Seizures , Skull/abnormalities , Syndrome
20.
Cytogenet Cell Genet ; 50(2-3): 102-6, 1989.
Article in English | MEDLINE | ID: mdl-2776474

ABSTRACT

Usher syndrome is an autosomal recessive disease characterized by dual sensory impairments; affected individuals are born with a sensorineural hearing loss and ultimately lose their sight as retinitis pigmentosa develops. Conventional protein markers previously tested in a Louisiana Acadian kindred suggested tentative linkage to vitamin D-binding protein on chromosome 4. DNA linkage studies do not confirm this linkage relationship and exclude much of chromosome 4 as the site of the Usher syndrome gene in these families.


Subject(s)
Blindness/genetics , Chromosomes, Human, Pair 4 , Deafness/genetics , Female , Genes, Recessive , Genetic Linkage , Genetic Markers , Humans , Male , Pedigree , Syndrome
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