Basaloid squamous carcinoma with collagenous spherules and crystalloids.

A case of basaloid squamous carcinoma with unusual spheruloid and crystalloid structures occurring in the left submandibular region of 45-year-old woman is described. The tumor displayed features typical of basaloid squamous carcinoma. In addition, there were numerous eosinophilic deposits of extracellular matrix, which reacted positively on periodic acid-Schiff staining. These deposits were arranged in lamellar concentric and radial patterns. Ultrastructurally, they were composed of extracellular matrix components rich in basement membrane substances. A few banded collagen fibers were found in some deposits. Basaloid squamous carcinoma is an aggressive variant of squamous cell carcinoma, with a predilection to the head and neck region, that needs to be distinguished from other tumors that may contain abundant deposits of basement membrane rich material, especially from adenoid cystic carcinoma.

Prolapse of the fallopian tube after hysterectomy associated with exuberant angiomyofibroblastic stroma response: a diagnostic pitfall.

We report two cases of prolapse of the fallopian tube associated with an exuberant angiomyofibroblastic stroma response, which occurred after hysterectomy and which is a hitherto unreported feature of this lesion. The tumors were composed of richly vascularized stroma arranged in a retiform pattern and mildly atypical glandular inclusions, which had the morphology of tubal epithelium. The stroma of the lesion was composed of either thin bipolar cells with tapered nuclei and stellate-shaped cells with minimal amount of cytoplasm or small epithelioid-looking cells with eosinophilic cytoplasm. The tubal glandular inclusions displayed mildly atypical nuclear features. If the tubal glandular component was overlooked, these tumors might be erroneously diagnosed as mesenchymal lesions of the vagina, such as vaginal fibroepithelial polyp, angiomyofibroblastoma, aggressive angiomyxoma, or superficial myofibroblastoma.