Subject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Biomarkers, Tumor/analysis , Breast Neoplasms/drug therapy , Neoplasms, Hormone-Dependent/drug therapy , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Aromatase Inhibitors/therapeutic use , Breast Neoplasms/chemistry , Chemotherapy, Adjuvant , Drug Administration Schedule , Female , Humans , Neoplasms, Hormone-Dependent/chemistry , Premenopause , Tamoxifen/therapeutic use , Treatment OutcomeABSTRACT
Recently, the rates of early stage breast cancers involving breast-conserving therapy have increased due to use of mammography screening. Morever, a patient's desire to keep the breast is now considered to be a factor which determines the surgery tactics. However, there has been so far no consensus on optimal extent of surgery capable of preventing local recurrence. In order to precisely estimate such risk it is essential to take into account factors such as tumor size, surgical margin status and age. Besides, correlations between certain subtypes of breast cancer and various associated risks of local recurrence are to be established. Another important factor is to devise the necessary subsequent radiotherapy.
Subject(s)
Breast Neoplasms/pathology , Breast Neoplasms/surgery , Mastectomy, Segmental , Neoplasm Recurrence, Local/diagnosis , Age Factors , Breast Neoplasms/diagnosis , Breast Neoplasms/radiotherapy , Early Detection of Cancer , Female , Humans , Neoplasm Staging , Radiotherapy Planning, Computer-Assisted , Radiotherapy, Adjuvant , Risk Assessment , Risk FactorsABSTRACT
Nanobiotechnology, defined as an arm of a nano-system is a rapidly developing area of medicine. Nanomaterials ranging from 1 to 1000 nm in size offer unique advantages of interaction with biological systems on the molecular level. Nanobiotechnologies can be used in definition, diagnosis and treatment of cancer thus leading to the new development of a new discipline--nanooncology. The potential of nanoparticles to be used in in-vivo tumor visualization, biomolecular profiling of tumor growth factors and targeted drug delivery is being studied. These methods stemming from nanotechnology may soon find a broad application in oncology.
