ABSTRACT
La metayodobencilguanidina radiomarcada es un análogo de la norepinefrina que se utiliza en la localización de tumores que expresan transportadores de dicha neurohormona, especialmente los derivados de la cresta neural y de origen neuroendocrino, y en el tratamiento de sus metástasis cuando estas no son quirúrgicas. En la literatura revisada se encuentran mejorías sintomáticas, asociadas a un descenso de los niveles hormonales, en un porcentaje no despreciable de casos tras el tratamiento con 131I-MIBG. Sin embargo, la remisión tumoral completa se ha descrito en muy pocas ocasiones y casi nunca en presencia de metástasis óseas. Presentamos un caso de feocromocitoma maligno que tras el tratamiento con 131I-MIBG (600 mCi) alcanzó una respuesta hormonal y metabólica completa a pesar de la existencia de metástasis óseas (AU)
Radiolabeled metaiodobenzylguanidine is an analogue of norepinephrine used to localize tumors that express the neurohormone transporters, specifically those derived from the neural crest having a neuroendocrine origin. It is also used to treat non-surgical metastases derived from them. A review of the literature revealed symptomatic improvements associated to a decrease in hormone levels in a significant percentage of patients after 131I-MIBG treatment. However, complete tumor remission has been described only in very few cases and hardly ever when bone metastases exist. We present a case of a patient diagnosed of malignant pheochromocytoma who achieved complete hormonal and metabolic response after 131I-MIBG treatment (600 mCi) in spite of the presence of bone metastases (AU)
Subject(s)
Humans , Male , Adult , 3-Iodobenzylguanidine/therapeutic use , Pheochromocytoma/complications , Pheochromocytoma , Radionuclide Imaging/instrumentation , Radionuclide Imaging/methods , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methods , Tomography, Emission-Computed/instrumentation , Tomography, Emission-Computed/methods , Tomography, Emission-Computed , Nuclear Medicine/methods , Nuclear Medicine/standardsABSTRACT
Radiolabeled metaiodobenzylguanidine is an analogue of norepinephrine used to localize tumors that express the neurohormone transporters, specifically those derived from the neural crest having a neuroendocrine origin. It is also used to treat non-surgical metastases derived from them. A review of the literature revealed symptomatic improvements associated to a decrease in hormone levels in a significant percentage of patients after (131)I-MIBG treatment. However, complete tumor remission has been described only in very few cases and hardly ever when bone metastases exist. We present a case of a patient diagnosed of malignant pheochromocytoma who achieved complete hormonal and metabolic response after (131)I-MIBG treatment (600 mCi) in spite of the presence of bone metastases.
Subject(s)
3-Iodobenzylguanidine/therapeutic use , Adrenal Gland Neoplasms/drug therapy , Antineoplastic Agents/therapeutic use , Pheochromocytoma/drug therapy , Adrenal Gland Neoplasms/metabolism , Adrenal Gland Neoplasms/pathology , Bone Neoplasms/secondary , Humans , Male , Neurotransmitter Agents/biosynthesis , Pheochromocytoma/metabolism , Pheochromocytoma/secondary , Remission Induction , Young AdultABSTRACT
Mujer de 53 años diagnosticada de cáncer colorrectal, quien recibió tratamiento quirúrgico y quimioterápico, tras 5 años de remisión completa presenta una evolución atípica de su patología oncológica. La utilidad de la PET/TAC con 18F-FDG ha sido fundamental para la detección de las recidivas, sospechadas y no sospechadas, y para la monitorización de la respuesta al tratamiento(AU)
A 53-year-old woman with diagnosis of colorectal cancer, who received surgical treatment and chemotherapy. After 5-years of complete remission, she showed an atypical oncological evolution. The utility of 18F-FDG PET/CT scan has been fundamental to detect suspected and unsuspected recurrence and to monitor response to treatment(AU)
Subject(s)
Humans , Female , Middle Aged , Fluorodeoxyglucose F18/therapeutic use , Colorectal Neoplasms/diagnosis , Neoplasm Metastasis , Chemotherapy, Adjuvant , /methods , Positron Emission Tomography Computed Tomography/methods , Positron Emission Tomography Computed Tomography , Colorectal Neoplasms/physiopathology , Colorectal Neoplasms , Radiography, Thoracic , Biomarkers, Tumor/administration & dosage , Nuclear Medicine/methods , Positron Emission Tomography Computed Tomography/instrumentation , Positron Emission Tomography Computed Tomography/trendsABSTRACT
A 53-year-old woman with diagnosis of colorectal cancer, who received surgical treatment and chemotherapy. After 5-years of complete remission, she showed an atypical oncological evolution. The utility of (18)F-FDG PET/CT scan has been fundamental to detect suspected and unsuspected recurrence and to monitor response to treatment.
Subject(s)
Adenocarcinoma/diagnostic imaging , Colorectal Neoplasms/pathology , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Multimodal Imaging , Pancreatic Neoplasms/diagnostic imaging , Positron-Emission Tomography , Radiopharmaceuticals , Thyroid Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adenocarcinoma/drug therapy , Adenocarcinoma/surgery , Chemotherapy, Adjuvant , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/surgery , Female , Humans , Leiomyoma , Middle Aged , Neoplasms, Second Primary , Pancreatic Neoplasms/drug therapy , Thyroid Neoplasms/drug therapy , Thyroid Neoplasms/pathology , Uterine NeoplasmsABSTRACT
This paper aims to present the usefulness of the different diagnosis imaging methods (anatomical and functional) in the characterization of bone injury. Any data, however insignificant, is justified and should be specified. In this case, the discrepancy between the vascular and pool phases in the bone scintigraphy with 99mTc-MDP reveals revealed a lesion with an intense reaction secondary to the "foreign body effect", which is not necessarily malignant.
Subject(s)
Femoral Neoplasms/diagnostic imaging , Osteoma, Osteoid/diagnostic imaging , Radiopharmaceuticals , Technetium Tc 99m Medronate/analogs & derivatives , Adolescent , Diagnosis, Differential , Foreign-Body Reaction/diagnostic imaging , Humans , Magnetic Resonance Imaging , Radionuclide ImagingABSTRACT
El objetivo es presentar la utilidad de los distintos métodos de diagnóstico por imagen (anatómicos y funcionales), en la caracterización de una lesión ósea.Cualquier dato, por insignificante que este sea, tiene su justificación y debe ser especificado. En este caso, la discrepancia en la gammagrafía ósea con 99mTc-MDP, entre las fases vascular y 'pool', revela a una lesión con intensa reacción secundaria al efecto de 'cuerpo extraño', que necesariamente no tiene que ser maligna (AU)
