ABSTRACT
Introducción: el carcinoma hepatocelular (CHC) es una neoplasiacon una elevada incidencia y una alta mortalidad.Objetivo: nuestro objetivo es la descripción de la historia naturalde una cohorte de pacientes con CHC e identificar variablesasociadas a supervivencia.Material y métodos: estudio retrospectivo y descriptivo depacientes diagnosticados de CHC entre 1995-2002. Las variablescualitativas se expresaron mediante frecuencias y porcentajes y lascuantitativas con mediana y desviación típica. La supervivencia seestimó mediante el método de Kaplan Meyer y la prueba de LogRank.Resultados: se analizaron un total de 154 pacientes con CHC.La ratio hombre-mujer fue de 2,9/1. La edad media de 68 ± 9 años.El 82% de los pacientes fueron exitus en un tiempo medio de seguimientode 28 meses. La mediana de supervivencia fue de 21,5 meses(IC 95%: 16,98-26,04). Se realizó tratamiento con intención curativaen un 40,3% y el resto tratamiento paliativo. Las variablesasociadas a la supervivencia fueron: presencia o no de ascitis, el númerode lesiones en el momento del diagnóstico y si el tratamientorealizado fue con intención curativa o no. No hubieron diferenciasestadísticamente significativas respecto a: sexo, edad, etiología de lacirrosis y estadio de Child en el momento del diagnóstico.Conclusiones: los factores asociados a una menor supervivenciaen los pacientes con carcinoma hepatocelular fueron lapresencia de ascitis y el número de lesiones en el momento deldiagnóstico. La realización de tratamiento con intención curativase asocia a una mayor supervivencia
Background: hepatocellular carcinoma (HCC) is a cancerwith high incidence and mortality.Objective: our aim was to describe the natural history of a patientcohort with HCC, and to identify the factors associated withsurvival.Patients and methods: a retrospective and descriptive studyof patients diagnosed with HCC between 1995 and 2002. Qualitativevariables were expressed as frequencies and percentages.Quantitative variables were expressed as medians and standarddeviations. Survival was calculated using the Kaplan-Meier methodand log rank.Results: a total of 154 patients were analyzed. The men-towomenratio was 2.9/1. Mean age was 68 ± 9 years. 82% of patientsdied during a median follow-up of 28 months. Median survivalwas 21.5 months (95% CI: 16.98-26.04). Curativetreatment was done in 40.3% of diagnosed patients, and 59.7%of patients received palliative treatment. Factors associated withsurvival were: ascites, number of lesions at diagnosis, and curativetreatment. No statistical differences were found for the next factors:age, sex, etiology of cirrhosis, and Child-Pugh stage at diagnosis.Conclusions: factors associated with low survival in patientswith HCC were ascites and number of lesions. Curative treatmentis associated with a higher survival when compared to palliative treatment
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Carcinoma, Hepatocellular/epidemiology , Liver Neoplasms/epidemiology , Treatment Outcome , Embolization, Therapeutic , Survival Analysis , Spain/epidemiology , Risk Factors , Retrospective Studies , Palliative Care , Liver Transplantation , Liver Neoplasms/diagnosis , Liver Neoplasms/therapy , Cohort Studies , Carcinoma, Hepatocellular/diagnosis , Carcinoma, Hepatocellular/therapyABSTRACT
BACKGROUND: hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality. OBJECTIVE: our aim was to describe the natural history of a patient cohort with HCC, and to identify the factors associated with survival. PATIENTS AND METHODS: a retrospective and descriptive study of patients diagnosed with HCC between 1995 and 2002. Qualitative variables were expressed as frequencies and percentages. Quantitative variables were expressed as medians and standard deviations. Survival was calculated using the Kaplan-Meier method and log rank. RESULTS: a total of 154 patients were analyzed. The men-to-women ratio was 2.9/1. Mean age was 68 +/- 9 years. 82% of patients died during a median follow-up of 28 months. Median survival was 21.5 months (95% CI: 16.98-26.04). Curative treatment was done in 40.3% of diagnosed patients, and 59.7% of patients received palliative treatment. Factors associated with survival were: ascites, number of lesions at diagnosis, and curative treatment. No statistical differences were found for the next factors: age, sex, etiology of cirrhosis, and Child-Pugh stage at diagnosis. CONCLUSIONS: factors associated with low survival in patients with HCC were ascites and number of lesions. Curative treatment is associated with a higher survival when compared to palliative treatment.
