ABSTRACT
Vegan protein-based diet has attracted increasing interest in the prevention of metabolic syndrome (MetS). Meanwhile, adiponectin has become a highly potential molecular target in the prevention of MetS. Our study will identify a potential vegan protein diet for the prevention of MetS using rat models. Thirty-six Wistar rats were randomly assigned into three groups and given diets containing one of the following proteins for 12 weeks: casein (CAS, control diet), soy protein (SOY), and gluten-soy mixed protein (GSM). Changes in metabolic parameters as well as the expressions of adiponectin and its receptors were identified. Compared to CAS diet, both SOY and GSM diets led to decreases in blood total cholesterol and triglycerides, but only GSM diet led to an increase in HDL-cholesterol; no marked difference was observed in blood glucose in all three groups; HOMA-IR was found lower only in SOY group. Among groups, the order of serum adiponectin level was found as GSM > SOY > CAS. Similar order pattern was also observed in expression of adiponectin in adipose tissue and AdipoR1 mRNA in skeletal muscle. Our results suggested for the first time that, besides SOY diet, GSM diet could also be a possible substitute of animal protein to prevent MetS.
Subject(s)
Adiponectin/metabolism , Diet, Vegan , Dietary Proteins/pharmacology , Glutens/pharmacology , Metabolic Syndrome/metabolism , Receptors, Adiponectin/metabolism , Soybean Proteins/pharmacology , Adiponectin/blood , Adipose Tissue/drug effects , Adipose Tissue/metabolism , Animals , Insulin Resistance , Male , Metabolic Syndrome/diet therapy , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolism , RNA, Messenger/metabolism , Rats, Wistar , Receptors, Adiponectin/geneticsABSTRACT
OBJECTIVE: To explore the long-term dynamic effects of different dietary proteins on the body weights and serum lipids in rats. METHODS: Thirty-six male adult Wistar rats were randomized into casin protein group, soy protein group and the glutelin-soy mixed protein group by body weight. After fed for 12 weeks, the body weights and blood lipid levels in soy protein group were measured. RESULTS: The body weights, wet weight of fat pad, the ratios between fat and body weight, TG and TC levels were significantly lower than those in casin protein group (P < 0.05), while the HDL-C was not significantly different between these two groups. Additionally, rats fed with glutelin-soy mixed protein, had a significantly lower levels of TC and TG (P < 0.05), but a significantly higher level of HDL-C in comparison with the other two groups (P < 0.05). CONCLUSION: Soy protein intake could significantly reduce TC and TG level in rats. And this effect could be significant when the soy protein and the glutelin protein were intaked. Interestingly, mixed protein could be significantly reduce HDL-C level.
