ABSTRACT
An asymmetric Friedel-Crafts hydroxyalkylation reaction of 5-aminoisoxazoles with pyrazole-4,5-diones was developed under the catalysis of 5% chiral copper complexes. This reaction exhibits functional group tolerance and excellent enantioselectivity. Moreover, the reaction can be scaled up and its mechanism was studied.
ABSTRACT
Ventricular assist devices or total artificial hearts can be used to save patients with heart failure when there are no donors available for heart transplantation. Blood pumps are integral parts of such devices, but traditional axial flow blood pumps have several shortcomings. In particular, they cause hemolysis and thrombosis due to the mechanical contact and wear of the bearings, and they cause blood stagnation due to the separation of the front and rear guide wheel hubs and the impeller hub. By contrast, the implantable axial flow, maglev blood pump has the characteristics of no mechanical contact, no lubrication, low temperature rise, low hemolysis, and less thrombosis. Extensive studies of axial flow, maglev blood pumps have shown that these pumps can function in laminar flow, transitional flow, and turbulent flow, and the working state and performance of such pumps are determined by their support mechanisms and flow channel. Computational fluid dynamics (CFD) is an effective tool for understanding the physical and mechanical characteristics of the blood pump by accurately and effectively revealing the internal flow field, pressure-flow curve, and shear force distribution of the blood pump. In this study, magnetic levitation supports were used to reduce damages to the blood and increase the service life of the blood pump, and a conical impeller hub was used to reduce the speed, volume, and power consumption of the blood pump, thereby facilitating implantation. CFD numerical simulation was then carried out to optimize the structural parameters of the conical axial maglev blood pump, predict the hemolysis performance of the blood pump, and match the flow channel and impeller structure. An extracorporeal circulation simulation platform was designed to test whether the hydraulic characteristics of the blood pump met the physiological requirements. The results showed that the total pressure distribution in the blood pump was reasonable after optimization, with a uniform pressure gradient, and the hemolysis performance was improved.
Subject(s)
Heart Failure , Heart-Assist Devices , Computer Simulation , Equipment Design , Hemolysis , Humans , HydrodynamicsABSTRACT
To improve the accuracy and actual road equivalence of vehicle performance testing using test benches, a double-drum test bench that meets the test requirements of vehicle control system prototypes and in-use vehicles was designed. Dynamic models of the single-wheel test bench and the vehicle test bench were established, and mechanisms were theoretically analyzed for single-wheel variable adhesion and vehicle load transfer for equivalent testing using the variable placement angle. The mechanism of electromechanical inertia compensation was studied to realize stepless simulation of vehicle inertia and simulate dynamic load while braking. The simulation model of the vehicle test bench system was established based on MATLAB/Simulink. Simulations were carried out to verify the anti-lock braking system (ABS) performance test functionality of the test bench under high adhesion, bisectional, and low adhesion conditions. Referring to the simulation conditions, ABS tests under actual test bench and road conditions were carried out. Results demonstrated that the mechanism of variable load transfer simulation by electromechanical inertia compensation improves the equivalent accuracy compared to that of its road test equivalent, verifying the feasibility of the simulation mechanism. This study could help further improve the accuracy and reduce the cost of vehicle performance testing, thus greatly benefitting the vehicle development and testing industry.
