ABSTRACT
Encapsulating nanomaterials in carbon is one of the main ways to increase the cathode stability, but it is difficult to simultaneously optimize the rate capacity and enhance durability derived from the insufficient ion transport channels and deficient ion adsorption sites that constipate the ion transport and pseudocapacitive reaction. Herein, we develop the ligand-confined growth strategy to encapsulate the nano-Na3V2(PO4)3 cathode material in various carbon channels (microporous, mesoporous, and macroporous) to discriminate the optimal carbon channels for synchronously improving rate capacity and holding the high-rate cycle stability. Benefiting from the unobstructed ion/charge transport channels and flexible maskant created by the interconnected mesoporous carbon channels, the prepared Na3V2(PO4)3 nanoparticles confined in mesoporous carbon channel (Mes-NVP/C) achieve a discharge-specific capacity of 70 mAh g-1 even at the ultrahigh rate of 100 C, higher than those of the Na3V2(PO4)3 nanoparticles confined in microporous and macroporous carbon channel (Micr-NVP/C and Macr-NVP/C), respectively. Significantly, the capacity retention rate of Mes-NVP/C after 5000 cycles at 20 C is as high as 90.48%, exceeding most of the reported work. These findings hold great promise for traditional cathode materials to synergistically realize fast charging ability and long cycle life.
ABSTRACT
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of people worldwide and the subsequent epidemiological statistics highlights the implication of the disease. AD is a multi-factorial disease, a variety of single-target directed drugs that have reached clinical trials have unsuccessful. Hence, various factors associated without set of AD have been considered in targeted drug discovery and development. Triazoles are five-membered heterocyclic scaffold due to their broad range of biological activities. The present review focuses on the recent developments in the area of medicinal chemistry to explore the diverse chemical structures of potential inhibitors of Alzheimer's disease and also look at its structure-activity relationships (SAR) studies of bioactive compounds for future discovery of suitable drug candidates. The prominence has been given on the major advancements in the medicinal brochure of this pharmacophore for the period during 2012-2019.
Subject(s)
Alzheimer Disease/drug therapy , Cholinesterase Inhibitors/pharmacology , Neuroprotective Agents/pharmacology , Triazoles/pharmacology , Acetylcholinesterase/metabolism , Alzheimer Disease/metabolism , Butyrylcholinesterase/metabolism , Cholinesterase Inhibitors/chemistry , Dose-Response Relationship, Drug , Humans , Molecular Structure , Neuroprotective Agents/chemistry , Structure-Activity Relationship , Triazoles/chemistryABSTRACT
OBJECTIVE: To assess the value of fiberoptic ductoscopy (FDS) in the diagnosis of nipple discharge. METHODS: Clinical records of 1,025 patients with nipple discharge undergoing FDS from February 2006 to March 2008 were reviewed. RESULTS: There were obviously differences in the FDS diagnosis of various nipple discharge traits. The diagnosis by FDS was pathologically confirmed in 93.7%of patients with nipple discharge (404/431). CONCLUSION: FDS can effectively improve the diagnosis of nipple discharge,and has great clinical significance.
