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1.
Parasitol Int ; 67(6): 751-758, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30055333

ABSTRACT

Intestinal schistosomiasis caused by S. japonicum has long been a threat to the health of residents within endemic areas, especially along the mid-tier of the Yangtze River basin as well as the Dongting and Poyang lakes. Therefore, we collected monitoring data from 2005 to 2014 in Lushan City, Jiujiang City, Jiangxi Province, which is located downstream of Poyang Lake. We conducted a logistic regression analysis in 2005 and in 2008 and then conducted a time series analysis from 2005 to 2014 in Lushan city. The results of the logistic regression analysis showed that after integrated measures were implemented in Lushan city in 2004, the infection rate of intestinal schistosomiasis decreased sharply in different populations, but fishermen had a greater risk of contracting intestinal schistosomiasis in both 2005 and 2008. From the time series analysis, we found that the infection rate decreased sharply from 2005 to 2009 and then increased slowly from 2009 to 2011 before finally becoming relatively stable and the predicated infection rates in HES, SM2, and SM3 are -1.14%, 0.35%, 0.29%, respectively, compared with 0.41% of schistosomiasis infection in 2014, showing a downward trend. Our study indicated that the integrated measures initiated in 2004 in Lushan city had a positive effect on controlling intestinal schistosomiasis, but we should still emphasize special treatment of particular populations, such as fishermen, and should consider environmental changes, such as changes in the water level of Poyang Lake, in the future.


Subject(s)
Intestinal Diseases, Parasitic/epidemiology , Schistosoma japonicum/physiology , Schistosomiasis japonica/epidemiology , Animals , China/epidemiology , Cities/epidemiology , Humans , Intestinal Diseases, Parasitic/parasitology , Logistic Models , Risk Factors , Schistosomiasis japonica/parasitology
2.
Cryobiology ; 76: 24-33, 2017 06.
Article in English | MEDLINE | ID: mdl-28478125

ABSTRACT

Lower conception rates and litter sizes limit the wide use of artificial insemination with frozen-thawed boar sperm, due to a lack of understanding of the mechanisms that cause cryodamage and cryoinjury to sperm during cryopreservation. CryoMiRs, a family of freeze-related microRNAs (miRNAs), are associated with freeze tolerance, and regulate metabolism in mammalian hibernators and insects. Thus, we speculate that miRNAs maybe involved in the regulation of the freeze-thaw process and may affect boar sperm function. In this study, we studied the differential expression of 46 miRNAs that have roles in spermatogenesis, sperm maturation, and sperm quality in response to cryopreservation (with or without 3% glycerol). The results indicated that, in response to cryopreservation with 3% glycerol, 14 miRNAs were significantly up-regulated, but only two miRNAs (miR-22 and miR-450b-5p) were significantly down-regulated, relative to fresh sperm. Preservation with 3% glycerol caused up-regulation of 17 miRNAs, but only caused down-regulation of one miRNA (miR-24), relative to sperm cryopreserved without glycerol. Functional annotations of these differentially expressed miRNAs indicated that these miRNAs and their targets are mainly associated with metabolic and cellular processes. Therefore, our findings show that cryopreservation results in changes in miRNA expression, and suggest that the anti-freeze mechanisms of boar sperm need to be studied further.


Subject(s)
Cryopreservation , MicroRNAs/metabolism , Semen Preservation , Spermatozoa , Animals , Cryoprotective Agents/pharmacology , Freezing , Glycerol/pharmacology , Male , Spermatogenesis/drug effects , Swine
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