1.
Analyst
; 142(2): 273-278, 2017 01 16.
Article
in English
| MEDLINE
| ID: mdl-27900373
ABSTRACT
The fabrication of sub-nanoliter fluidic channels is demonstrated, with merely 10 nm depth on germanium, using conventional semiconductor device fabrication methods and a polymer assisted room-temperature sealing method. As a first application, an ultralow volume (650 pL) was studied by ATR-IR spectroscopy. A detection limit of â¼7.9 × 1010 molecules of human serum albumin (HSA) (â¼0.2 mM) in D2O was achieved with highly specific ATR-IR spectroscopy.