Subject(s)
Clustered Regularly Interspaced Short Palindromic Repeats , Genetic Engineering , Genetic Predisposition to Disease/prevention & control , Genome, Human , Germ Cells , Targeted Gene Repair , Biotechnology/ethics , Gene Transfer, Horizontal , Genetic Engineering/ethics , Genomics , Humans , Risk ManagementABSTRACT
One of the most visible and contentious issues regarding the fairness of the original system of organ procurement and allocation is the argument that it resulted in great disparities in the total amount of time a patient waited for an organ (i.e. the time from registration at a transplantation center to transplant), depending on where he or she lived. In an attempt to resolve this debate, Congress charged the National Academy of Sciences, Institute of Medicine to perform an independent study of the original system and proposed rule changes. In an analysis of approximately 68,000 transplant waiting list records, the committee developed several conclusions and recommendations largely specific to liver transplantation policies. The purpose of this paper is to describe both the results of the study and the statistical foundations of the mixed-effects multinomial logistic regression model that led to the committee's conclusions.
