ABSTRACT
In general, small-mid size research laboratories struggle with managing clinical and secondary datasets. In addition, faster dissemination, correlation and prediction of information from available datasets is always a bottleneck. To address these challenges, we have developed a novel approach, Document Oriented Graphical Analysis and Prediction (DO-GAP), a hybrid tool, merging strengths of Not only SQL (NoSQL) document oriented and graph databases. DO-GAP provides flexible and simple data integration mechanism using document database, data visualization and knowledge discovery with graph database. We demonstrate how the proposed tool (DO-GAP) can integrate data from heterogeneous sources such as Genomic lab findings, clinical data from Electronic Health Record (EHR) systems and provide simple querying mechanism. Application of DO-GAP can be extended to other diverse clinical studies such as supporting or identifying weakness of clinical diagnosis in comparison to molecular genetic analysis.
Subject(s)
Databases, Factual , GenomicsABSTRACT
Extraction and use of Electronic Health Record (EHR) data is common in retrospective observational studies. However, electronic extraction and use of EHR data is rare during longitudinal prospective studies. One of the reasons is the amount of processing needed to assess data quality and assure consistency in meaning and format across multiple investigational sites. We report a case study of and lessons learned from acquisition and processing of EHR data in an ongoing basis during a clinical study.