1.
Vaccine
; 29(32): 5195-202, 2011 Jul 18.
Article
in English
| MEDLINE
| ID: mdl-21619909
ABSTRACT
This randomized, double-blind study evaluated concomitant administration of 13-valent pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in adults aged ≥65 years who were naïve to 23-valent pneumococcal polysaccharide vaccine. Patients (N=1160) were randomized 1:1 to receive PCV13+TIV followed by placebo, or Placebo+TIV followed by PCV13 at 0 and 1 months, with blood draws at 0, 1, and 2 months. Slightly lower pneumococcal serotype-specific anticapsular polysaccharide immunoglobulin G geometric mean concentrations were observed with PCV13+TIV relative to PCV13. Concomitant PCV13+TIV demonstrates acceptable immunogenicity and safety compared with either agent given alone.
Subject(s)
Influenza A virus/immunology , Influenza Vaccines/immunology , Pneumococcal Vaccines/immunology , Aged , Aged, 80 and over , Double-Blind Method , Female , Humans , Immunization Schedule , Immunoglobulin G/blood , Influenza Vaccines/administration & dosage , Influenza Vaccines/adverse effects , Male , Placebos/administration & dosage , Pneumococcal Vaccines/administration & dosage , Pneumococcal Vaccines/adverse effects , Polysaccharides, Bacterial/immunology , Streptococcus pneumoniae/immunology , Vaccines, Conjugate/adverse effects , Vaccines, Conjugate/immunology
2.
Diabetes Care
; 22(3): 533-5, 1999 Mar.
Article
in English
| MEDLINE
| ID: mdl-10097948