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Transplant Proc ; 42(2): 448-50, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20304161

ABSTRACT

To study whether treatment with L-arginine (ARG), a substrate of nitric oxide biosynthesis, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits treated with ARG (100 mgxkg(-1), intravenously) or saline solution (SS) prior to I (60 minutes) by occlusion of superior mesenteric artery and/or during R (120 minutes). After I or I/R, 2-cm jejunal segments were isolated and mounted in an organ bath to study of neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared to the sham group, jejunal contractions were similar in I + ARG, but reduced in I + SS, I/R + SS, and I/R + ARG groups. The jejunal enteric nerves were damaged in I + SS, I/R + SS, and I/R + ARG, but not in I + ARG group, suggesting that ARG can attenuate intestinal dysfunctions due to I, but not to R.


Subject(s)
Arginine/pharmacology , Intestines/blood supply , Nitric Oxide/biosynthesis , Reperfusion Injury/prevention & control , Animals , Arginine/therapeutic use , Blood Circulation , Femoral Vein/physiology , Gastrointestinal Motility/drug effects , Gastrointestinal Motility/physiology , Ischemia/physiopathology , Jejunum/blood supply , Jejunum/drug effects , Jejunum/pathology , Mesenteric Artery, Superior/physiology , Rabbits , Reperfusion/adverse effects , Reperfusion Injury/physiopathology
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