ABSTRACT
PURPOSE: To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis (NK). METHODS: A prospective case series review was performed in 14 patients with NK who started treatment with nicergoline as an off-label prescription from January to November 2020. Patients with a epithelial defect or corneal ulcer due to NK were treated with oral nicergoline. RESULTS/SERIAL CASES: Complete corneal healing was observed in 10 (71.4%) of the 14 patients after 25.6 ± 26.60 days (range 7-90) with nicergoline. In three (21.5%) patients wound healing was not achieved, and one patient (7.1%) was lost to follow-up. The mean time between diagnosis and the starting of nicergoline was 10.92 ± 8.85 days (0-28). No adverse effects of nicergoline were observed. CONCLUSION: Nicergoline as an adjunctive treatment for NK showed a potential use in the healing of epithelial defect in real-life clinical practice.
Subject(s)
Corneal Ulcer , Nicergoline , Humans , Corneal Ulcer/diagnosis , Corneal Ulcer/drug therapySubject(s)
Keratomileusis, Laser In Situ , Myopia , Cornea , Corneal Stroma , Humans , Lasers, Excimer , Myopia/surgerySubject(s)
Descemet Stripping Endothelial Keratoplasty/adverse effects , Endothelium, Corneal/transplantation , Fuchs' Endothelial Dystrophy/surgery , Graft Rejection/diagnostic imaging , Aged, 80 and over , Air , Allografts , Descemet Membrane/pathology , Descemet Membrane/surgery , Female , Graft Rejection/diagnosis , Humans , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Tissue Adhesions/diagnosis , Tissue Adhesions/etiologySubject(s)
Corneal Edema/diagnostic imaging , Corneal Transplantation/adverse effects , Descemet Stripping Endothelial Keratoplasty/adverse effects , Postoperative Complications/diagnostic imaging , Surgical Wound Dehiscence/diagnostic imaging , Air , Corneal Edema/diagnosis , Corneal Edema/etiology , Endothelium, Corneal/pathology , Graft Survival , Humans , Postoperative Complications/diagnosis , Surgical Wound Dehiscence/diagnosis , Surgical Wound Dehiscence/etiologyABSTRACT
No disponible
Subject(s)
Humans , Lenses, Intraocular , Vision Tests/standards , Contrast Sensitivity , Vision Tests/instrumentationABSTRACT
PURPOSE: To observe trends in surgical techniques for corneal transplantation and main indications in our hospital over the past five years. METHODS: Retrospective descriptive study, including all keratoplasties performed at the Hospital Clinic of Barcelona, Spain, between January 2014 and December 2018. RESULTS: In total, 332 keratoplasties were performed. In total, 127 (38.25%) were penetrating keratoplasties (PK), and 205 (61.75%) were lamellar keratoplasties (LK). In 2014, a total of 48 keratoplasties were carried-out, whereas in 2018, the total was 93, which represents a 93.75% increase in corneal transplantation surgeries. Eye bank-delivered precut tissue for DMEK was introduced in 2016, and 3 cases (6.25%), were carried out that year. In 2018, DMEK became the leading technique with 56 cases (60.22%). Fuchs' dystrophy was the leading indication for corneal transplant (37.63%) in 2018. CONCLUSION: Introduction of DMEK in a single center can be implemented in a relatively short period of time, becoming the most popular surgical procedure in corneal transplantation. A possible factor encouraging this change is the availability of eye bank-delivered precut tissue, and standardization of donor preparation and host surgical steps, optimizing surgical time in the operating room. This trend should lead to better visual outcomes, faster recovery times, and eventually to a higher surgical volume per year.
Subject(s)
Corneal Diseases/surgery , Corneal Transplantation/trends , Descemet Stripping Endothelial Keratoplasty/trends , Adult , Aged , Aged, 80 and over , Corneal Diseases/epidemiology , Corneal Transplantation/methods , Corneal Transplantation/statistics & numerical data , Descemet Membrane/surgery , Descemet Stripping Endothelial Keratoplasty/methods , Endothelium, Corneal/surgery , Endothelium, Corneal/transplantation , Female , Fuchs' Endothelial Dystrophy/epidemiology , Fuchs' Endothelial Dystrophy/surgery , Humans , Keratoplasty, Penetrating/methods , Male , Middle Aged , Postoperative Complications/epidemiology , Postoperative Complications/surgery , Retrospective Studies , Spain/epidemiology , Tissue DonorsSubject(s)
Anti-Bacterial Agents/adverse effects , Ciprofloxacin/adverse effects , Cornea/pathology , Keratitis/drug therapy , Pseudomonas Infections/drug therapy , Aged , Anti-Bacterial Agents/analysis , Anti-Bacterial Agents/pharmacokinetics , Chemical Precipitation , Ciprofloxacin/analysis , Ciprofloxacin/pharmacokinetics , Cornea/chemistry , Crystallization , Female , Fuchs' Endothelial Dystrophy/surgery , Herpes Zoster Ophthalmicus/complications , Humans , Hydrogen-Ion Concentration , Keratitis/microbiology , Keratoplasty, Penetrating , Preservatives, Pharmaceutical , Tomography, Optical CoherenceSubject(s)
Endothelium, Corneal/diagnostic imaging , Endothelium, Corneal/injuries , Eye Injuries/diagnosis , Adult , Corneal Edema/diagnosis , Corneal Edema/etiology , Corneal Edema/pathology , Endothelium, Corneal/pathology , Eye Injuries/etiology , Humans , Male , Slit Lamp Microscopy , Tomography, Optical Coherence , Wounds, Gunshot/complications , Wounds, Gunshot/diagnosisSubject(s)
Glaucoma Drainage Implants , Glaucoma, Open-Angle/surgery , Intraocular Pressure/physiology , Stents , Tenon Capsule/pathology , Aged , Female , Glaucoma, Open-Angle/diagnosis , Glaucoma, Open-Angle/physiopathology , Humans , Tenon Capsule/diagnostic imaging , Tomography, Optical Coherence , Tonometry, Ocular , Treatment OutcomeSubject(s)
Anterior Chamber/diagnostic imaging , Anterior Chamber/surgery , Corneal Opacity/surgery , Corneal Transplantation , Keratitis, Herpetic/surgery , Microbubbles , Air , Anterior Chamber/pathology , Corneal Opacity/diagnosis , Corneal Opacity/etiology , Corneal Transplantation/adverse effects , Corneal Transplantation/methods , Descemet Membrane/diagnostic imaging , Descemet Membrane/pathology , Descemet Membrane/surgery , Humans , Keratitis, Herpetic/complications , Keratitis, Herpetic/diagnosis , Microbubbles/adverse effects , Microbubbles/therapeutic use , Tomography, Optical CoherenceABSTRACT
INTRODUCTION: To determine outcomes of conjunctival autograft attached with fibrin glue (FG) for primary pterygium, and compare these outcomes in expert versus closely supervised trainee ophthalmologists. METHODS: This was a retrospective, comparative, non-randomized, interventional study. Patients were recruited among those with primary nasal pterygium undergoing FG conjunctival autograft. Surgery was performed by expert (136 eyes) or closely supervised trainee (128 eyes) ophthalmologists. Mean follow-up was 7.82±8.23months. Main outcome measures were recurrence rate, reoperation rate and complications. RESULTS: The study sample comprised 264 eyes of 225 patients. Participants were of mean age 47.09±12.89years; 46.7% were male, 28.4% Caucasian and 70.5% Hispanic. Recurrence was recorded in 6.4%: 5.9% in the expert group and 7% in the trainee group (P=0.704) and reoperation in 1.9%: 0.7% and 3.1% (P=0.202), respectively. Both groups showed similar rates of complications such as transient graft edema, graft dehiscence, hematoma or ocular hypertension. Reoperation was slightly more frequent in patients younger than 40years (P=0.064). CONCLUSIONS: Good outcomes were observed for FG conjunctival autografting in primary pterygium surgery, with no differences recorded between supervised trainee and expert surgeons. Our findings suggest the need to supervise pterygium surgeries during training.
Subject(s)
Conjunctiva/transplantation , Fibrin Tissue Adhesive/therapeutic use , Ophthalmologists/education , Pterygium/surgery , Transplantation, Autologous/methods , Adult , Aged, 80 and over , Autografts , Female , Follow-Up Studies , Humans , Learning Curve , Male , Middle Aged , Organization and Administration , Postoperative Complications/epidemiology , Recurrence , Reoperation/statistics & numerical data , Retrospective Studies , Treatment Outcome , Young AdultABSTRACT
No disponible
Subject(s)
Child , Humans , Male , Optic Disk Drusen/diagnosis , Calcinosis/physiopathology , Visual Field Tests , Fluorescence , Tomography, Optical CoherenceSubject(s)
Blindness/history , Education of Visually Disabled/history , Reading , Sensory Aids/history , Accidents, Occupational , Blindness/etiology , Education of Visually Disabled/methods , Eye Injuries/complications , Faculty , History, 19th Century , Humans , Male , Ophthalmia, Sympathetic/etiology , Paris , Teaching/historyABSTRACT
CASE REPORT: A 24 year old woman who complained of maculo-papulo rash, genital and bucal aphthous ulcers, abdominal pain, minor dyspnea and visual loss in both eyes. Funduscopy revealed a bilateral occlusive vasculitis including central vessels. Treatment was initiated with a methylprednisolone bolus (1 g/24h) and infliximab 5mg/kg/day (0-2-6 weeks and every 8 weeks). The treatment prescribed induced a fast remission. Visual acuity improved. The patient did not suffer any other relapse after one year of follow-up. DISCUSSION: An initial treatment with Infliximab should be considered in Behçet disease for serious outbreaks, such as macular occlusive vasculitis with ischemia.
