ABSTRACT
We studied ten patients with Cystic fibrosis. The purposes of this study were to investigate the presence of gastroesophageal reflux and establish the probable association between gastroesophageal reflux and pulmonary and gastric involvement. All 10 patients underwent 24-hour esophageal pH recording, spirometry and gastric function. Abnormal reflux index was found in all these patients. Lung function was pathologic in the 3 older children. There were no relationship between the severity of the gastroesophageal reflux and the degree of pulmonary damage. No patient has gastric acid hypersecretion. Eight of 10 patients had steatorrhea. Our findings confirm the high frequence of gastroesophageal reflux in cystic fibrosis.
Subject(s)
Cystic Fibrosis/complications , Gastroesophageal Reflux/etiology , Lung/physiopathology , Stomach/physiopathology , Adolescent , Child , Cystic Fibrosis/physiopathology , Female , Gastric Acidity Determination , Gastroesophageal Reflux/physiopathology , Humans , Male , Respiratory Function TestsABSTRACT
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
Subject(s)
Celiac Disease/physiopathology , Edetic Acid/pharmacokinetics , Glutens/administration & dosage , Intestinal Absorption , Administration, Oral , Biopsy , Case-Control Studies , Celiac Disease/metabolism , Child , Child, Preschool , Diet , Edetic Acid/administration & dosage , Edetic Acid/analysis , Female , Humans , Intestinal Mucosa/pathology , MaleABSTRACT
Presentamos un estudio sobre la permeabilidad intestinal en una serie de diez niños diagnosticados de enfermedad celiaca cuando tomaban una dieta con gluten y tenían una atrofia severa de las vellosidades intestinales y posteriormente durante un período con dieta sin gluten y vellosidades intestinales normales. Tomamaos como grupo control a diez niños sanos. Se utilizó como marcador el EDTA-Cr51 (Etiléndiaminotetracetato Cr51) administrado por vía oral. Su excreción urinaria estaba signficativamente elevada en los pacientes con biopsia alterada, manteniéndose una moderada elevación en los pacientes celiacos con dieta exenta de gluten y sin atrofia de las vellosidades
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Intestinal Absorption , Edetic Acid/administration & dosage , Celiac Disease/complications , Glutens/administration & dosage , Edetic Acid/analysis , Administration, Oral , Biopsy , Case-Control Studies , Diet , Intestinal Mucosa/pathologyABSTRACT
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
ABSTRACT
Presentamos un estudio sobre la permeabilidad intestinal en una serie de diez niños diagnosticados de enfermedad celiaca cuando tomaban una dieta con gluten y tenían una atrofia severa de las vellosidades intestinales y posteriormente durante un período con dieta sin gluten y vellosidades intestinales normales. Tomamaos como grupo control a diez niños sanos. Se utilizó como marcador el EDTA-Cr51 (Etiléndiaminotetracetato Cr51) administrado por vía oral. Su excreción urinaria estaba signficativamente elevada en los pacientes con biopsia alterada, manteniéndose una moderada elevación en los pacientes celiacos con dieta exenta de gluten y sin atrofia de las vellosidades (AU)
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Intestinal Absorption/drug effects , Edetic Acid/administration & dosage , Celiac Disease/complications , Glutens/administration & dosage , Edetic Acid/analysis , Intestinal Mucosa/pathology , Biopsy , Diet , Administration, Oral , Case-Control StudiesSubject(s)
Inflammatory Bowel Diseases , Adolescent , Child , Child, Preschool , Colon/surgery , Combined Modality Therapy , Enteral Nutrition , Humans , Infant , Inflammatory Bowel Diseases/diagnosis , Inflammatory Bowel Diseases/etiology , Inflammatory Bowel Diseases/therapy , Parenteral NutritionABSTRACT
We present 28 children, 4 to 14 year-old, with duodenal ulcer; there were 21 males and 7 females. In 16 cases, after stimulation with pentagastrin, basal pepsinogen I (PG1), basal gastrinemia and basal acid output (BAO) and maximal acid output (MAO) were measured. Compared to controls, the mean levels of PG1 and gastrin were significantly higher in the patients; 12 children (80%) had high levels of PG1 and the remaining 3 (20%) had normal levels. The blood group O was the most prevalent: 64% of the cases.
Subject(s)
Duodenal Ulcer/physiopathology , Gastric Acid/metabolism , Gastrins/blood , Pepsinogens/blood , ABO Blood-Group System , Adolescent , Child , Child, Preschool , Disease Susceptibility , Duodenal Ulcer/blood , Female , Gastroscopy , Humans , Male , PentagastrinABSTRACT
In order to determine the prevalence of hepatitis B virus (HBV) markers, we studied 375 healthy children, 242 males and 113 females, with age ranged between 6 to 14 years, from different schools at the Tetuán district (Madrid). We sent a questionnaire to the parents to investigate the presence of risk factor in the children and/or their parents. All children were screened for hepatitis B markers in serum. Our results shown the existence of HBV markers in 22 (5.9%) children. No major incidence of risk factors was found in the children with serologic evidence of HBV infection.
Subject(s)
Hepatitis B virus/isolation & purification , Adolescent , Carrier State/diagnosis , Carrier State/epidemiology , Carrier State/immunology , Carrier State/microbiology , Child , Female , Health Surveys , Hepatitis B virus/immunology , Humans , Male , Mass Screening , Spain/epidemiologyABSTRACT
A randomized, double-blind trial was performed to assess serological response and clinical protection for acute gastroenteritis due to rotavirus in 103 children aged 6 to 18 months, after a single dose of RIT 4237 live attenuated bovine rotavirus vaccine or placebo. Seroconversion, determined by enzyme-linked immunoabsorbent assay (ELISA), was significantly greater in initially seronegative vaccines compared with control group (p less than 0.0001); clinical protection rate was low in this study group and it is therefore concluded that seroconversion by itself is not sufficient to measure vaccine efficacy.
