Breed and non-genetic risk factors associated with the prevalence of subclinical mastitis in livestock systems of Arauca, Colombian orinoquia.

Subclinical Mastitis (SCM) is caused by several factors associated with the interaction of the individual cow, cow management, and the environment. The aim of this study was to assess the breed and non-genetic risk factors on the prevalence of SCM in cows from the dual-purpose livestock system on the floodplain of Arauca, Colombian Orinoquia. Milk samples were taken from the individual mammary quarters of 481 cows representing 28 different farms where the electrical conductivity (EC) test applied. To determine the factors associated with SCM, a multiple logistic regression analysis was used. The response variable was the SCM presence (1), or absence (0) obtained with the EC test. Breed was included as a genetic risk factor, and as non- genetic risk factors: number of cows in production, daily milk production, lactation month, cow age, climatic period, body condition, and calving number. The factors that were significantly associated with the SCM presence were body condition, climatic period, and breed (p < 0.05). Odds ratio (OR) analysis of significant effects indicates that for each unit increase in body condition, the OR of having animals with SCM is reduced by 71%. In the dry period the OR of animals with SCM increases by 150% compared to the rainy period. Composite breeds reduce the OR of SCM animals by 73%, compared with Indicus-predominance animals. In this study, the occurrence of SCM in extensive management systems in Arauca, Colombian Orinoquia, is determined by the risk factors of breed, climatic period, and body condition.

Early Cannon Development in Females of the "Sanmartinero" Creole Bovine Breed.

The variation in the dimensions of the body of living beings in relation to their size, function, or shape is known as allometry. Allometry studies allow the analysis of the function of body structures and their relationship with the performance and survival of breeds and species. The aim of this study was to describe the ontogenetic characteristics of the weight of certain bone elements of the Sanmartinero creole bovine breed, from an early age (6 months) until maturity. A total of 79 females of the Sanmartinero creole bovine breed with an age range of 0.5 to 10 years were studied. Body measurements were obtained individually using standard procedures: cannon perimeter, thoracic perimeter, body length, withers height, and body weight. Functional and production indices were obtained for animals aged more than 3 years (n = 53): corporal index, anamorphosis index, dactylo thoracic index, and the relative thickness of the cannon. The correlation between body weight and the cannon perimeter showed no trend towards a plateau. In the Sanmartinero creole bovine, therefore, a very early development of the cannon perimeter is detected, which could lead to bone fragility in heavier animals. Therefore, data suggest little harmony with appendicular bone development, i.e., with less robust cannons which are those necessary to support body mass. It is suggested that in genetic improvement programs of the Sanmartinero creole bovine, the measurement of the cannon perimeter, the withers height, and the thoracic perimeter should be considered.

Mini-percutaneous nephrolithotomy: Is smaller better for kidney stones in patients with neurogenic bladder?

INTRODUCTION: Patients with neurologic bladder are at an increased risk for urolithiasis, and currently, data on mini-percutaneous nephrolithotomy in this population are limited. Our objective was to compare mini (15F)-percutaneous nephrolithotomy, standard (24F)-PCNL and flexible ureteroscopy in terms of efficacy and safety in treatment of kidney stones in patients with neurogenic lower urinary tract dysfunction (NLUTD). METHODS: We conducted a retrospective monocentric study in our neuro-urological referral centre. All consecutive patients with NLUTD and a cumulative size of renal calculi greater than 15mm or 10mm in the lower calyx, who had extraction surgery between 2005 and 2020, were included. The primary endpoint was the one-session stone-free rate (SFR) at 3 months on a CT scan. The secondary endpoints were complication (Clavien-Dindo grading system), operative time, blood loss and length of hospital stay. RESULTS: We performed 76 standard PCNL (sPCNL), 46 flexible ureteroscopy lithotripsy (fURL) and 25 miniaturized PCNL (mPCNL). The one-session SFR was 37.5% for the mPCNL group, 38.2% for the sPCNL group and 37% for the fURL group with no significant difference between the three procedures (P=0.99). Early complications, blood loss and transfusion rates were lower in the mPCNL group than in the sPCNL group (P=0.047) and comparable to fURL group. The final SFRs after a second intervention for mPCNL, sPCNL and fURL were 48%, 61.8% and 63%, respectively (P=0.67). CONCLUSION: The efficacy of mPCNL in patients with NLUTD was not different from other techniques, but a significantly lower rate of complications than sPCNL was observed. LEVEL OF PROOF: 3.

Environmental and Breed Risk Factors Associated with the Prevalence of Subclinical Mastitis in Dual-Purpose Livestock Systems in the Arauca Floodplain Savannah, Colombian Orinoquia.

The aim of this study was to assess the environmental and breed risk factors associated with the prevalence of subclinical mastitis (SCM) in cows in the dual-purpose livestock system of Arauca, Colombian Orinoquia. Milk samples were taken from 1924 mammary quarters, corresponding to 481 cows on 28 different farms, and the California Mastitis Test (CMT) was applied. Risk factors associated with SCM were determined using multiple logistic regression analysis. The response variable was the presence (1) or absence (0) of SCM. Breed was included as a genetic risk factor, and daily milk production, number of cows in production, lactation month, calving number, cow age, climatic period, and body condition were included as environmental risk factors. The analysis of the odds ratio (OR) of significant effects indicated that the factors significantly associated with the presence of SCM were the number of cows (OR = 2.29; p = 0.005), milk production (OR = 0.88; p = 0.045), and the Taurus-Indicus breeds (OR = 1.79; p = 0.009) and composite breed (OR = 3.95; p = 0.005). In this study, the occurrence of SCM was determined by the following risk factors: number of cows, milk production, and breed. Likewise, the highest prevalence seemed to occur on farms with less technological development and sanitary management of producers from the lowest socioeconomic stratum.

Chemical Composition and In Vitro Ruminal Fermentation Characteristics of Native Grasses from the Floodplain Lowlands Ecosystem in the Colombian Orinoquia.

Grasses from lowland ecosystems in flooded savannahs are useful to feed extensive grazing animals; however, scarce information about its agronomic and fermentation characteristics exists. This study aims to determine the chemical composition and fermentation parameters of native grasses from the floodplain lowlands ecosystem in the Colombian Orinoquia. Three native grasses (Leersia hexandra, Acroceras zizanioides and Hymenachne amplexicaulis) and a "control" grass (introduced Urochloa arrecta-Tanner grass) were sown and sampled at 30, 40 and 50 days of age. On each sampling date, biomass production in a 1 m2 frame was estimated, and the chemical composition and fermentation parameters were analyzed using near-infrared spectroscopy and the in vitro gas production technique, respectively. Data were analyzed using a mixed model for repeated measures and the least significant difference (LSD) was used for mean differentiation (p < 0.05). The grasses' nutritional characteristics varied as follows: dry matter (DM, 0.7-2.0 ton/ha), crude protein (CP, 6.1-12.2%), neutral detergent fiber (NDF, 56.6-69.6%), ash (5.8-15.8%) and dry matter digestibility (DMD) between 20.8 and 60.6% from 12 to 48 h of fermentation. Native plants such as L. hexandra and A. zizanioides presented higher biomass production, CP, ash, cellulose, and Ca levels than the control plant. During the experimental period (30 to 50 days), the grasses did not present significant nutrient availability changes. In terms of fermentation characteristics, L. hexandra increased ammonia concentrations and total volatile fatty acids (TVFA) and butyric acid. This latter effect was also observed in A. zizanioides grass. L. hexandra and A. zizanioides grasses constitute a valuable alternative forage resource during the flooding times of the studied ecosystem.

Physiological traits of newborn piglets associated with colostrum intake, neonatal survival and preweaning growth.

Colostrum intake, which is critical for piglet survival after birth and growth up to weaning, greatly depends on piglet weight and vitality at birth. Our aim was to identify a set of biological variables explaining individual variations in colostrum intake, preweaning growth and risk of dying. Farrowing traits, morphological traits and colostrum intake were determined for 504 piglets born alive from 37 Landrace × Large White sows. A subset of 203 of these piglets was used to measure plasma neonatal concentrations of metabolites and hormones in blood collected from the umbilical cord at birth. From univariate analyses, we established that colostrum intake was positively associated with plasma neonatal concentrations of IGF-I, albumin, thyroid hormones (P < 0.001), and non-esterified fatty acids (P < 0.05), and was negatively associated with concentrations of lactate (P < 0.001). In a multivariable analysis, the variables explaining the variation in colostrum intake were piglet birth weight and rectal temperature 1 h after birth (positive effect, P < 0.001), time of birth after the onset of parturition, and fructose plasma concentrations at birth (negative effects, P < 0.001 and P < 0.05, respectively). Piglets that died within 3 days after birth had lower neonatal concentrations of albumin (P < 0.001), IGF-I and thyroxine (P < 0.01) than surviving piglets. Preweaning growth was positively associated with neonatal concentrations of IGF-I, thyroxine (P < 0.001), albumin and insulin (P < 0.05). Cortisol and glucose concentrations at birth were not related to colostrum intake, neonatal survival or preweaning growth. Multivariable analyses confirmed that colostrum intake was the predominant factor influencing piglet survival within 3 days after birth and preweaning growth. These results provide physiological indicators of piglet colostrum intake, besides birth weight. They also confirm the impact of time of birth during farrowing on colostrum intake and the crucial importance of physiological maturity at birth for postnatal adaptation.

Basicranial Modular Organization. A Study in the Araucanian Horse of Colombia.

The skull is divided into neurocranium and splanchnocranium, and its variation allows ecomorphological studies to learn about possible evolutionary and adaptive characteristics. The basicranial organization of the neurocranium and splanchnocranium modules was studied in a sample of 31 skulls from adult Araucanian horses by means of 2D geometric morphometric techniques. The neurocranium and splanchnocranium modules on the ventral aspect were analyzed separately using a set of 31 landmarks. The RV coefficient (the multivariate analog of a correlation) was estimated to analyze the independence of these two parts, as well as their morphological integration, using a two-block analysis of least squares. The study results confirm the modular development of the neurocranium and the splanchnocranium, the former being more stable than the latter as well as low morphological integration between the two. The development between both parties is structured in a modular way but allows relative independence. Now it would be interesting for future studies to add muscles (those that connect the cranial parts, but also the cervical), the hyoid apparatus, and the ossicles of the internal ear and the jaw and analyze if they behave as integrated modules between them. Since this research has been conducted at the subspecific breed level, it could be plausible that in other breeds, this integrative development was different.

Examination of Shape Variation of the Skull in British Shorthair, Scottish Fold, and Van Cats.

A variety of skull shapes are frequently used for discrimination between animal species, breeds, and sexes. In this study, skulls of three different breeds of cats were examined by the geometric morphometric method, with the aim of revealing skull shape differences. For this purpose, 27 cats (6 British Shorthair, 7 Scottish Fold, and 14 Van cats) were used. The skulls of cats were modeled by computed tomography. Geometric morphometrics was applied using dorsal (8 landmarks, 63 semilandmarks) and lateral (8 landmarks, 63 semilandmarks) skull projections on these models. Centroid size differences between the breeds were statistically insignificant. However, the differences in shape were statistically significant for both the dorsal view and lateral view. Shape variation was less in the British Shorthair than in other breeds. Shape differences generally occurred around the orbit. In the skull of Scottish Folds, the orbit was situated more caudally than in other breeds. The British Shorthair had the largest orbital ring. In dorsal view, the Scottish Fold had the largest orbital diameter. The orbital ring of Van cats was smallest in both dorsal and lateral views. In the canonical variate analysis, it was seen that the breeds were separated from each other. The shape difference in the skull between different cat breeds could be revealed by geometric morphometrics. The results of this study provide useful information for taxonomy.

Would the Cephalic Development in the Purebred Arabian Horse and Its Crosses Indicate a Paedomorphic Process?

This study examined paedomorphosis in PAH and F1 crossbreds. A sample of 99 horses was selected from 40 different breeders and consisted of three groups: stallions (n = 16), mares (n = 53), and geldings (n = 30), ranging from 10 months to 27 years in age. All horses presented a concave celloid lateral left head profile in the acquired photographic images. The hypothesis proposed in this study suggested the lateral profile of the head in juveniles was representational in the adult form due to the neonate's facial bones (part of the splanchnocranium) developing at a different rate to those of the skull. The methodology utilized geometric morphometrics to identify 23 landmarks so as to identify profile curvature indicative between the three groups (stallions, mares, and geldings). Principal component analysis reduced the number of variables to 14 examinable landmarks. Using a two-NPMANOVA and multivariate regression test, it was demonstrated that an isometric relationship between the concave celloid profile in the juvenile and its adult counterpart existed. This result supported the hypothesis that PAH and F1 crossbreds expressed a paedomorphic trait due to the adult form retaining the concave celloid profile identified in the juvenile.

Morphological Differences between Sheep and Goat Calcanea Using Two-Dimensional Geometric Morphometrics.

The distinction between bones of sheep and bones of goats is a difficult issue in zooarchaeology. Several studies undertaken in the past to facilitate this task have relied upon both qualitative criteria and osteometry. Geometric morphometrics has proved to be a powerful tool to evaluate morphological differences in a rigorous and detailed manner. This study aims to analyse variations in the morphology of the calcaneum among sheep and goats based upon two-dimensional geometric morphometrics (GM). Twenty landmarks were selected on the surfaces of 79 calcanea (47 sheep and 32 goats) to calculate the principal components of shape variations among these specimens. Clear interspecific differences in the morphology of this bone were extracted. Most are located on the calcaneal tuber and neck, the sustentacular tali region, the articular surfaces of both the malleolus and the cubonavicular. Furthermore, the use of GM methods has enabled us to assess small but significant amounts of geometric variation that are difficult to measure using traditional morphometric techniques. They provide a new and useful perspective to what is already known in the published literature. Our results shed new light upon the possibility of the existence of qualitative features that may help to distinguish caprine breeds.

Discharge Opioids are Unnecessary Following Radical Cystectomy.

OBJECTIVE: To show that zero-opioid discharges after both open and robotic cystectomy are feasible and to examine the impact of zero-opioid discharges on patient interaction with the physician's office. MATERIALS AND METHODS: One hundred seven patients who underwent either open or robotic radical cystectomy from March 1, 2020 to December 30, 2020 were identified. Patient demographics, perioperative data, and 30 day pain related outcomes including phone calls, office visits, requests for pain medication, emergency department visits, and readmissions were abstracted from the chart. We then examined variables associated with a zero-opioid discharge. RESULTS: Thirty-two patients were discharged with an opioid prescription (Median Oral Morphine Equivalents Prescribed = 90) and 75 were discharged without an opioid prescription. On regression analysis, age (OR 1.07, 95% CI [1.02-1.12]) and pathology (OR 0.36, 95% CI[0.14-0.9]) remained significantly associated with post-operative opioid prescriptions. There were no differences in the percent of patients presenting to the emergency department, being readmitted, calling the office, calling the office regarding pain, or requesting opioid prescriptions within 30 days of discharge, or the number of post-operative office visits (P >.05 for all). CONCLUSION: Patients can safely be discharged home without opioids following cystectomy, regardless of robotic or open approach. Age and pathology are predictors of the need for an opioid prescription on discharge. These patients did not have increased follow-up visits, phone calls, or requests for pain medication.

Afección pericárdica y miocárdica tras infección por SARS-CoV-2: estudio descriptivo transversal en trabajadores sanitarios / Pericardial and myocardial involvement after SARS-CoV-2 infection: a cross-sectional descriptive study in healthcare workers

Introducción y objetivos Las secuelas cardiacas tras la infección por SARS-CoV-2 todavía están poco documentadas. Se realizó un estudio transversal en trabajadores sanitarios para estudiar la prevalencia de afección pericárdica y miocárdica tras la infección por SARS-CoV-2. Métodos Se estudió a 139 trabajadores sanitarios con infección previa confirmada por SARS-CoV-2. Los participantes se sometieron a evaluación clínica, electrocardiograma, laboratorio, incluido el perfil de células inmunitarias, y resonancia magnética cardiaca (RMC). El diagnóstico clínico de pericarditis se realizó ante la presencia de los criterios clásicos y el diagnóstico clínico de miocarditis ante la presencia de al menos 2 criterios de RMC. Resultados La mediana de edad fue de 52 (41–57) años, el 71,9% eran mujeres, y el 16,5% había sido hospitalizado previamente por neumonía por COVID-19. En la evaluación (10,4 [9,3–11,0] semanas después de los síntomas de infección), todos los participantes presentaban estabilidad hemodinámica. El 41,7% presentaba dolor torácico, disnea o palpitaciones; el 49,6%, alteraciones electrocardiográficas; el 7,9%, elevación de NT-proBNP; el 0,7%, elevación de troponina; y el 60,4%, alteraciones en la RMC (AU)

Introduction and objectives The cardiac sequelae of SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in healthcare workers to report evidence of pericardial and myocardial involvement after SARS-CoV-2 infection. Methods We studied 139 healthcare workers with confirmed past SARS-CoV-2 infection. Participants underwent clinical assessment, electrocardiography, and laboratory tests, including immune cell profiling and cardiac magnetic resonance (CMR). Clinically suspected pericarditis was diagnosed when classic criteria were present and clinically suspected myocarditis was based on the combination of at least 2 CMR criteria. Results Median age was 52 (41-57) years, 71.9% were women, and 16.5% were previously hospitalized for COVID-19 pneumonia. On examination (10.4 [9.3-11.0] weeks after infection-like symptoms), participants showed hemodynamic stability. Chest pain, dyspnea or palpitations were present in 41.7% participants, electrocardiographic abnormalities in 49.6%, NT-proBNP elevation in 7.9%, troponin in 0.7%, and CMR abnormalities in 60.4%. A total of 30.9% participants met criteria for either pericarditis and/or myocarditis: isolated pericarditis was diagnosed in 5.8%, myopericarditis in 7.9%, and isolated myocarditis in 17.3%. Most participants (73.2%) showed altered immune cell counts in blood, particularly decreased eosinophil (27.3%; P<.001) and increased cytotoxic T cell numbers (17.3%; P <.001). Clinically suspected pericarditis was associated (P <.005) with particularly elevated cytotoxic T cells and decreased eosinophil counts, while participants diagnosed with clinically suspected myopericarditis or myocarditis had lower (P <.05) neutrophil counts, natural killer-cells, and plasma cells. Conclusions Pericardial and myocardial involvement with clinical stability are frequent after SARS-CoV-2 infection and are associated with specific immune cell profiles (AU)

No Morphological Integration of Dorsal Profiles in the Araucanian Horse (Colombia).

The aim of this research was to determine if the division between the cervical, dorsal, and croup profiles (three regions commonly assessed for descriptive profile purposes) has a modular basis as well as a morphological integration. For this, a total of 135 digital photographs were obtained, in a lateral view, of adult horses (14 females and 121 geldings; age range: 2-20 years), of the Araucanian breed, an equine population typical of the flooded savannah of Arauca, NE Colombia. From each image, 25 reference points (semi-landmarks) were obtained at the dorsal level of the neck, back, and croup. The hypothesis of the modularity of different body profiles based on differentiated regions was tested using the RV coefficient, and an analysis of two blocks of partial least-squares allowed the evaluation of the level of morphological integration. The results showed that each alloidic group reflected high integration but low modularity. The covariation between the modules was centered mainly on the withers, the loin, and the croup. For the studied profile blocks, no module can be considered. The absence of the fragmentation of the alloidic sets would promote the adaptive capacity of the breed by linking coordinated functional responses to similar selection pressures, e.g., field work. Although the integration between the neck, back, and croup profiles was proven, their modular covariation was low.

Shape Directional Asymmetry in Hindlimb Pairs among Calves (Bos Taurus).

The aim of this study was to determine paired asymmetries (right-left) in the autopods of bovine hindlimbs using geometric morphometry (GM). A total of 28 hindlimb right-left matched autopods belonging to healthy Brown Pyrenean calves were assessed. Dorsoplantar radiographs were obtained for each autopod. The bone shape was compared on right and left pairs by means of GM techniques, using a set of 15 landmarks. The results suggest that right and left distal limbs are, despite a perceived resemblance of symmetry, differently directionally developed in shape, with right hindlimbs tending to supinate (rotate outwards) and left hindlimbs tending to pronate (rotate inwards). This unevenness is probably related to the mediolateral forces' contribution of each limb in carrying out the tasks of propulsion and control during walking, and/or a consequence of a laterality associated with a lateralized grazing posture. Our findings prompt a new reassessment of the function of each bovine hindlimb during standing and locomotion.

Symmetry-Breaking Stabilities in Carapace Curvature on Testudo (Reptilia, Testudinidae).

The aim of this research was to contribute to the study of the doming geometry of Testudo carapace as an unstable point of equilibrium when animals are overturned. We performed this research using geometric morphometric using a sample of 64 Testudo individuals belonging to different species (T. hermannin = 30, T. graecan = 3, T. marginata n = 13 and T. horsfieldii n = 18), sexes and ages. A set of four sagittal landmarks (discrete homologous points) and 15 pairs of semi-landmarks, on the frontal doming of the carapace, were digitized on individual carapace pictures. Significative fluctuating asymmetry was detected, defined as small, completely random departures from bilateral symmetry, but much less than directional asymmetry, which appeared highly significative. Anti-symmetry did not appear. Carapace asymmetry was dominated by a clear right directionality. A possible biological speculation could be that this asymmetry more that easing the self-righting potential ("kinematic instability", understood as the ability to self-right without effort), makes stable ventral turning difficult ("static stability", understood as the ability to resist passively turning the body produced by destabilizing forces). This asymmetry is present among both sexes but more marked among males. An explanation for this sexually differentiated pattern could be the higher locomotion and the fight for mating in males, making them consequently more prone to losing their balance and falling on their back. These data may be useful in studying adaptative traits in Testudo species as well as establishing a seminal base for future studies. This research is the first attempt to explore a suitable method to assess doming asymmetry which could be useful in future, more extensive investigations, on a larger interspecific sample.

No modularity at ventral level in the horse skull.

Morphological integration and modularity are concepts that refer to the covariation level between the components of a structure. Morphological modules are independent subsets of highly correlated traits. The horse skull has been studied as a whole functional structure for decades, but the integrative approach towards quantitative examination of modules is scarce. We report here the first evaluation of cranial modularity in the horse at basal level. For this, we studied the modularity hypothesis for splanchnocranium and basicranium modules in the horse, two phenotipic regions under local influence by soft-tissue-hard-tissue interfaces. Using geometric morphometrics to capture the shape and location, we examined both modules in a sample of 23 dry skulls belonging to Pyrenean Horse Breed using 57 two-dimensional cranial landmarks. Modules were compared through partial least squares analyses and Escoufier (RV) coefficient. We tested whether the integration (measured by Escoufier RV coefficient) of splanchnocranium and basicranium strength modules and their covariation pattern (as analysed by partial least squares analysis) subordinate and express similar integration results. A clear modularity was observed. The lack of disproportions in the skulls of domestic horse breeds (compared to dog and cat breeds, for instance) might be an expression of the lack of single modules to evolve. On the other side, integration might have a positive impact on survival as long as the selection pressure is along the trajectory of integrated variation.

Comparación del neurocráneo entre el gato doméstico (Felis catus Linneas 1758) y el montés (Felis silvestris Schreber, 1777) mediante técnicas de morfometría geométrica / Comparison of neurocranium between domestic cat (fFlis catus Linneas 1758) and wild cat (Felis silvestris Schreber, 1777) by means of geometric morphometric techniques

RESUMEN: El objetivo de este estudio fue comparar objetivamente las diferencias en la forma total (tamaño y forma pura) del neurocráneo entre un grupo de cráneos de gatos domésticos (Felis catus, n=81), y un grupo de gato montés (Felis silvestris, n=12) mediante técnicas de morfometría geométrica. Para ello se obtuvieron fotografías digitales del lado izquierdo de los cráneos de un modo estandarizado, y en las que se ubicaron 8 landmarks y 9 semilandmarks. Después de una superposición generalizada de Procrustes se procedió a un análisis de componentes principales y a otro de canónico a fin de comparar y detectar las posibles diferencias. Los tamaños neurocraneales no mostraron diferencias entre ambos grupos, pero sí que aparecieron diferencias significativas en la forma. Los cambios de forma afectarían principalmente la sutura escamoso-parietal-alisfenoidal y, en menor medida, puntos caudales del cráneo, lo que sugeriría cambios a nivel de músculos masticatorios. A conocimiento del autor, constituye esta la primera investigación que caracteriza y compara el cráneo de los gatos mediante métodos de morfometría geométrica, recomendándose un mayor uso de esta técnica dada la escasez de publicaciones al respecto en mamíferos domésticos.

SUMMARY: The objective of this study was to objectively compare the differences in the total shape (size and pure shape) of the neurocranium between a group of domestic cat skulls (Felis catus, n=81), and wildcats (Felis silvestris, n=12) by means of geometric morphometric techniques. To achieve it, we obtained digital photographs of the left side of the skulls in a standardized form, in which 8 landmarks and 9 semilandmarks were located. After a Generalized Procrustes Superimposition, a Principal Component Analysis and a Canonical Analysis one were performed to compare and detect possible differences. Neurocranial sizes showed no differences between the two groups, however, significant differences in shape did appear. Shape changes would mainly affect the squamosal-coronal suture and, to a lesser extent, caudal skull points, therefore suggesting changes in masticatory muscles. As far as this author´s knowledge, this is the first research that characterizes and compares the skull of cats using geometric morphology methods, recommending greater use of this technique given the scarcity of publications on this subject in domestic mammals.

Diferencias morfométricas en el hueso palatino de la oveja (Ovis aries) y la cabra (Capra hircus) / Morphometric palatine differences between sheep (Ovis aries) and goat (Capra hircus)

RESUMEN: Un hueso craneal muy poco estudiado en anatomía veterinaria comparada es el palatino. En nuestro estudio, realizamos la comparación de este hueso entre la oveja (Ovis aries L., 1758) y la cabra (Capra hircus L., 1758), a partir de una muestra de 36 y 17 cráneos respectivamente, y utilizando métodos de morfometría geométrica. Se eligieron un total de 32 puntos (4 hitos y 28 semi-hitos) para analizar la lámina horizontal del hueso palatino. Se reflejaron diferencias estadísticamente significativas tanto para el tamaño como para la forma. En Capra se denota una clara expansión lateral del hueso y rostral y una contracción central, con un acercamiento relativo de los forámenes palatinos, mientras que en Ovis los forámenes están más lateralmente alejados. A nuestro parecer, esta mayor anchura y longitud de la lámina horizontal en Capra se explicaría por una mayor capacidad de frotación del alimento en relación a Ovis.

SUMMARY: Palatine is a cranial bone very less studied in comparative veterinary anatomy. In our study, we performed the comparison of this bone between sheep (Ovis aries L., 1758) and goat (Capra hircus L., 1758), from a sample of 36 and 17 skulls respectively, using methods of geometric morphology. A total of 32 points (4 landmarks and 28 semi-landmarks) were chosen to analyse the horizontal lamina of the palatine bone. Statistically significant differences were reflected for both size and shape. Capra denotes a clear lateral expansion of the bone and rostral and a central contraction, with a relative approach of palatine foramina, while in Ovis foramina are more laterally distant. In our view, this greater width of the horizontal lamina in Capra would be explained by a greater capacity to rub the food compared to Ovis.

Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms.

Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association "Adrenals" (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.