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2.
Dis Markers ; 2014: 278715, 2014.
Article in English | MEDLINE | ID: mdl-24692841

ABSTRACT

Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.


Subject(s)
Chemokines/metabolism , Renal Insufficiency, Chronic/metabolism , Animals , Biomarkers/metabolism , Chemokines/genetics , Child , Gene Expression , Humans , Kidney/metabolism , Kidney/pathology
3.
RBM rev. bras. med ; 70(1,n.esp)jan.-fev. 2013.
Article in Portuguese | LILACS | ID: lil-704850

ABSTRACT

Introdução: Os anticorpos específicos contra o doador (DSA) representam uma das principais barreiras para o sucesso do transplante renal. Material e métodos: Os cem receptores, classificados em baixo risco (BR), médio risco (MR), alto risco (AR) e muito alto risco (MAR) de terem rejeição mediada por anticorpos (RMA) foram transplantados com rins de doadores falecidos (DF). A sobrevida dos enxertos foi avaliada após um ano. Resultados: Dos 100 receptores que receberam rins de DF, 54 (54,0%) foram classificados como BR. Destes, oito rejeitaram (14,8%), três perderam os enxertos, sendo duas perdas por RMA (DSA MFI 1223 a 2341) e uma por causa não imunológica (CNI). Entre os 30 (30,0%) classificados em MR, 10 (33,3%) rejeitaram, desses quatro perderam os enxertos, sendo duas perdas por RMA (DSA MFI 530 e 870), uma por rejeição celular (RC) e uma por CNI. Entre os 10 (10,0%) classificados em AR, três rejeitaram, sendo observadas três perdas por RMA (DSA MFI de 3493 a 6068). Entre os 6 (6,0%) classificados como MAR, cinco tiveram episódios de rejeições, quatro perderam os enxertos, sendo três perdas por RMA (DSA MFI 7226 a 12591) e uma por RC. A sobrevida dos enxertos no primeiro ano para os pacientes em BR, MR, AR+MAR foi de 91,22%, 78,75% e 80,28%, respectivamente. Conclusão: Esse protocolo demonstrou ser eficiente e permitiu uma avaliação imunológica precisa de receptores classificados de acordo com o risco de RMA. Do total de pacientes, 26 (26%) tiveram episódios de rejeições, 12 (46%) pacientes perderam os enxertos devido a causas imunológicas, sendo duas perdas por RC e 10 por RMA, o que evidencia a gravidade das rejeições. Além disso, tivemos duas perdas por CNI. Após um ano, 87 (87%) dos pacientes mantiveram boa função renal, com creatinina variando de 0,9 a 1,6 mg/dL...


Subject(s)
Humans , Male , Female , Transplantation , Kidney Transplantation
4.
Int Urol Nephrol ; 44(5): 1539-48, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22544449

ABSTRACT

PURPOSE: Clinical- and histopathology-based scores are the limited predictors of allograft outcome. Thus, predictors of allograft survival still remain a challenge. This study aimed to evaluate the urinary levels of chemokines and anti-inflammatory molecules at 30, 90, and 300 days after renal transplantation and to further correlate these measurements to graft function. METHODS: Glomerular filtration rate (GFR) and urinary levels of MCP-1/CCL2, MIP-1α/CCL3, RANTES/CCL5, IL-8/CXCL8, IP-10/CXCL10, interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor-1, and receptor-2 were determined at 30, 90, and 300 days after renal transplantation in 22 patients. Transplanted patients were also divided according to the type of donor (living donor, LD, n = 13 or deceased donor, DD, n = 9). RESULTS: Urinary levels of all molecules, except MIP-1α/CCL3, remained unchanged at 30, 90, and 300 days after transplantation in our 22 patients. MIP-1α/CCL3 levels significantly reduced from 30 to 300 days and showed a negative correlation with GFR at 30 days. The comparison between LD and DD groups showed similar levels of all markers, except for MCP-1/CCL2, which presented higher values in LD than in DD at 30 days. sTNFR1 and MCP-1/CCL2 significantly reduced from 30 to 300 days in LD group, but only sTNFR2 concentrations at 30 days were negatively correlated with GFR at 300 days. On the other hand, in DD group, IL-1Ra concentrations at 30 and at 90 days were positively correlated with GFR at 300 days. CONCLUSION: Urinary chemokine and anti-inflammatory molecules measurements may be a promising tool in the follow-up of renal transplanted patients.


Subject(s)
Chemokines/urine , Glomerular Filtration Rate , Kidney Transplantation/physiology , Adult , Biomarkers/urine , Chemokine CCL2/urine , Chemokine CCL3/urine , Chemokine CCL5 , Chemokine CXCL10/urine , Female , Humans , Interleukin 1 Receptor Antagonist Protein/urine , Interleukin-8/urine , Kidney Transplantation/methods , Male , Middle Aged , Prospective Studies , Receptors, Tumor Necrosis Factor, Type I/urine , Receptors, Tumor Necrosis Factor, Type II/urine , Time Factors
5.
J. bras. nefrol ; 31(4): 286-296, out.-dez. 2009. tab
Article in Portuguese | LILACS | ID: lil-549915

ABSTRACT

O transplante renal é a melhor modalidade de terapia renal substitutiva até o momento. Infelizmente a sobrevida do enxerto é interrompida pelos episódios de rejeição aguda ou mesmo de fibrose intersticial atrofia tubular. A dosagem de quimiocinas e citrocinas urinárias como ferramenta alternativa para o diagnóstico dessas complicações tem sido relatada nos últimos anos. Estas substâncias estão sabidamente relacionadas com os mecanismos imunoinflamatórios do transplante renal podendo ser detectadas no tecido renal no plasma e na urina de pacientes transplantados. Drogas anti-inflamatórias inibidores do sistema renina angiotensina e alguns antagonistas de receptores de citocinas ainda utilizados em nível experimental podem interferir com a expressão desses mediadores do sistema imune e por conseguinte alterar a evolução do transplante renal. Neste sentido pretende-se neste artigo fazer uma revisão dos estudos sobre a mensuração de citocinas quimiocinas e dos seus receptores na urina no plasma e no tecido renal de pacientes transplantados no intuito de avaliar uma possível associação entre os níveis desses mediadores e as complicações do transplante renal e sobrevida do enxerto.


Renal transplantation is the best modality of renal replacement therapy so far. Unfortunately, graft survival is interrupted by episodes of acute rejection or tubular atrophy of interstitial fibrosis. The measurement of urinary chemokines and citrocinas as an alternative tool for the diagnosis of these complications have been reported in recent years. These substances are known to be related to immunoinflammatory mechanisms of renal transplantation can be detected in renal tissue in plasma and urine of transplant patients. Anti-inflammatory drugs inhibiting the renin angiotensin receptor antagonists and some cytokines also used on an experimental level can interfere with the expression of these mediators of the immune system and thus alter the course of renal transplantation. In this sense we intend to make this article a review of studies on the measurement of cytokines chemokines and their receptors in the plasma and urine in the renal tissue of patients transplanted in order to evaluate a possible association between the levels of these mediators and the complications of the transplant and renal graft survival.


Subject(s)
Humans , Male , Female , Cytokines/analysis , Cytokines/biosynthesis , Chemokines/analysis , Chemokines/biosynthesis , Graft Rejection/diagnosis , Kidney Transplantation/adverse effects , Kidney Transplantation/physiology
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