Sleep quality features and their association with mood symptoms and cognitive factors in a non-clinical sample of older Brazilian adults.

AIM: There is strong interest in sleep disorders in the elderly, but there are gaps in identifying how multiple factors affect sleep quality in this population. We aimed to assess sleep quality and its relationship to mood, general cognition, and sociodemographic factors in a sample of cognitively active older adults. METHODS: We assessed 105 non-clinical older adults (mean age ± SD: 69.64 ± 0.66 years) based on a sociodemographic profile questionnaire, the Beck Anxiety Inventory, the Beck Depression Inventory II, the Montreal Cognitive Assessment, the Pittsburgh Sleep Quality Index, and the Epworth Sleepiness Scale. Separate analyses were conducted, controlled by sleep quality and daytime sleepiness, to understand how variables were associated. RESULTS: About 46.7% of individuals had significantly poor sleep quality. Univariate analysis showed that non-workers had a lower risk of impaired sleep quality (prevalence ratio (PR) = 0.67; P = 0.044). However, there was an increased risk of poor sleep quality in those experiencing depressive symptoms (PR = 1.78; P < 0.001) and anxiety symptoms (PR = 1.98; P < 0.001). In multivariate analysis, the language component of the Montreal Cognitive Assessment (PR = 0.80; P = 0.011) was associated with a lower risk of poor sleep quality, and anxiety symptoms (PR = 1.99; P < 0.001) remained significantly associated with a higher risk of poor sleep quality. No significant difference was observed in variables related to daytime sleepiness. CONCLUSION: We found that overall quality of sleep potentially relates to mood, cognition, and sociodemographic factors. Further studies using multifactorial approaches to sleep investigation are required.

Structural characterization of a complex triterpenoid saponin from Albizia lebbeck and investigation of its permeability property and supramolecular interactions with membrane constituents.

As part of the ongoing efforts in discovering potentially bioactive natural products from medicinal plants, the present study was conducted to isolate a new complex triterpenoid saponin from the barks of Albizia lebbeck. It was isolated by using chromatographic methods and its structural elucidation was performed using detailed analyses of 1H and 13C NMR spectra including 2D-NMR (COSY, TOCSY, HSQC and HMBC) spectroscopic techniques, high-resolution electrospray ionization mass spectrometry (HRESIMS) analysis and chemical conversions. Its structure was established as 21-[[(2E,6S)-6-[6-deoxy-4-O-[(2E,6S)-6-hydroxy-2-(hydroxymethyl)-6-methyl-1-oxo-2,7-octadienyl]-[(ß-d-glucopyranosyl)oxy]-2-(hydroxymethyl)-6-methyl-1-oxo-2,7-octadienyl]-[(ß-d-glucopyranosyl)oxy]-2,6-dimethyl-1-oxo-2,7-octadienyl]oxy]-16-hydroxy-3-[[O-ß-d-xylopyranosyl-(1 → 2)-O-α-l-arabinopyranosyl-(1 → 6)-2-(acetylamino)-2-deoxy-ß-d-glucopyranosyl]oxy]-(3ß,16α,21ß)-olean-12-en-28-oic acid O-α-l-arabinofuranosyl-(1 → 4)-O-[ß-d-glucopyranosyl-(1 → 3)]-O-6-deoxy-α-l-mannopyranosyl-(1 → 2)-ß-d-glucopyranosyl ester (1). Additionally, this study aimed to investigate the permeability property of 1, its activity on membrane integrity and supramolecular interactions with cellular constituents using in vitro experimental models.