ABSTRACT
Periodontal disease is considered the main oral cavity disorder in dogs. Essential oils have the potential for use in the prevention and treatment of oral diseases. The antimicrobial activity of Schinus molle L. essential oil (SMEO) has already been reported. Chitosan, a natural product with antimicrobial activity and good biocompatibility has potential in biodental applications. In this study, we evaluated the in vitro antimicrobial activity of SMEO against bacteria associated with periodontal disease in dogs, developed and evaluated the physicochemical properties of a novel chitosan-based buccal delivery system containing SMEO. SMEO showed antimicrobial activity against Gram positive and Gram negative bacteria associated with canine periodontitis, with MIC values of 750 µg.mL-1 for Staphylococcus spp. and Streptococcus spp, 1000 µg.mL-1 for Corynebacterium spp. and 1250 µg.mL-1 for Pseudomonas spp. All formulations evaluated presented adequate physicochemical properties, good stability, and pH values close to buccal pH (5.0-7.0). Chitosan gel loaded with SMEO showed potential as a SMEO delivery system, having the ideal physicochemical and rheological properties (pseudoplastic and apparent viscosities) required for application on buccal tissue. Thus, we can conclude that formulation has the potential to be used for buccal mucosa delivery in the prevention and treatment of periodontal disease in dogs.
Subject(s)
Anacardiaceae , Chitosan , Oils, Volatile , Animals , Anti-Bacterial Agents , Chitosan/pharmacology , Dogs , Gels , Gram-Negative Bacteria , Gram-Positive Bacteria , Oils, Volatile/pharmacologyABSTRACT
A partir de uma casuística de 811 pacientes acidentados de trânsito, os autores apresentam os traumatismos que ocorreram na infância. Säo crianças de 0 a 12 años de idade, que foram atendidas no Hospital de Pronto Socorro de Porto Alegre, no setor de politraumatizados, no período de 21 de março de 1988 a 28 de junho de 1988, perfazendo-se um total de 100 dias de coleta de dados. Foram analisados os seguintes dados: idade, sexo, cor, circunstâncias do acidente (veículo envolvido, uso de proteçäo adequada, relaçäo do paciente com o veículo, condiçöes climáticas no momento do acidente, tempo decorrido até o atendimento), tipos de traumatismos, período de internaçäo e mortalidade
