ABSTRACT
INTRODUCTION: Although neurological complications are well recognized in patients with sickle cell disease, myelopathy has been rarely described, with few reported cases of compressive and ischemic myelopathy. We present the first case report of longitudinally extensive myelitis (LETM) in SCD and review the differential diagnosis of myelopathy in these patients. CASE PRESENTATION: We report the case of a 29-year-old African-Brazilian man with SCD, who experienced a subacute flaccid paraparesis, with T2 sensory level and urinary retention. Cerebrospinal fluid analysis showed a lymphocytic pleocytosis and increased protein levels. MRI disclosed a longitudinally extensive spinal cord lesion, with a high T2/STIR signal extending from C2 to T12. We searched Medline/PubMed, Embase, Scopus, and Google Scholar databases for myelopathy in SCD patients. DISCUSSION: Spinal cord compression by vertebral fractures, extramedullary hematopoietic tissue, and Salmonella epidural abscess have been reported in SCD. We found only three case reports of spinal cord infarction, which is unexpectedly infrequent compared to the prevalence of cerebral infarction in SCD. We found only one case report of varicella-zoster myelitis and no previous report of LETM in SCD patients. Specific and time-sensitive causes of myelopathy should be considered in SCD patients. In addition to compression and ischemia, LETM is a possible mechanism of spinal cord involvement in SCD patients.
Subject(s)
Anemia, Sickle Cell , Myelitis , Spinal Cord Compression , Spinal Cord Diseases , Adult , Anemia, Sickle Cell/complications , Humans , Magnetic Resonance Imaging , Male , Myelitis/diagnosis , Myelitis/etiology , Spinal Cord Diseases/diagnosis , Spinal Cord Diseases/etiologySubject(s)
Brain/diagnostic imaging , Cyclophosphamide/administration & dosage , Diabetes Insipidus, Neurogenic , Lupus Erythematosus, Systemic/complications , Methylprednisolone/administration & dosage , Myelitis, Transverse , Spinal Cord/diagnostic imaging , Antirheumatic Agents/administration & dosage , Diabetes Insipidus, Neurogenic/diagnosis , Diabetes Insipidus, Neurogenic/drug therapy , Diabetes Insipidus, Neurogenic/etiology , Diabetes Insipidus, Neurogenic/physiopathology , Diagnosis, Differential , Female , Humans , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/immunology , Magnetic Resonance Imaging/methods , Myelitis, Transverse/diagnosis , Myelitis, Transverse/etiology , Myelitis, Transverse/physiopathology , Myelitis, Transverse/therapy , Patient Acuity , Plasma Exchange/methods , Spinal Cord/pathology , Symptom Flare Up , Treatment Outcome , Young AdultABSTRACT
Dissection of cervical arteries constitutes a medical emergency. Although relatively rarely, activities classified as sports and recreation may be a cause of arterial dissection independently of neck or head trauma. The purpose of the present paper was to present a series of cases of cerebrum-cervical arterial dissection in individuals during or soon after the practice of these sports activities. Methods Retrospective data on patients with arterial dissection related to sports and recreation. Results Forty-one cases were identified. The most frequently affected vessel was the vertebral artery. A large variety of activities had a temporal relationship to arterial dissection, and jogging was the most frequent of these. This is the largest case series in the literature. Conclusion Arterial dissection may be a complication from practicing sports.
A dissecção das artérias cervicais é uma emergência médica. Embora de forma relativamente rara, certas atividades descritas como esportes e recreação podem ser a causa de dissecção arterial independentemente de trauma de crânio ou cervical. O propósito do presente estudo é apresentar uma série de casos de dissecção de artérias cérebro-cervicais em indivíduos durante ou logo após a prática destas atividades desportivas. Métodos Dados retrospectivos de pacientes com dissecção arterial relacionada à prática de esportes e recreação. Resultados Quarenta e um casos foram identificados. A artéria mais frequentemente afetada foi a vertebral. Uma grande variedade de atividades teve relação temporal com a dissecção arterial, sendo a corrida a mais frequente delas. Esta é a maior série de casos da literatura. Conclusão Dissecção arterial pode ser uma complicação da prática de esportes.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Athletic Injuries/complications , Carotid Artery, Internal, Dissection/etiology , Recreation , Sports/statistics & numerical data , Vertebral Artery Dissection/etiology , Cerebral Angiography , Carotid Artery, Internal, Dissection/pathology , Headache/etiology , Retrospective Studies , Risk Factors , Stroke/etiology , Vertebral Artery Dissection/pathologyABSTRACT
UNLABELLED: Dissection of cervical arteries constitutes a medical emergency. Although relatively rarely, activities classified as sports and recreation may be a cause of arterial dissection independently of neck or head trauma. The purpose of the present paper was to present a series of cases of cerebrum-cervical arterial dissection in individuals during or soon after the practice of these sports activities. METHODS: Retrospective data on patients with arterial dissection related to sports and recreation. RESULTS: Forty-one cases were identified. The most frequently affected vessel was the vertebral artery. A large variety of activities had a temporal relationship to arterial dissection, and jogging was the most frequent of these. This is the largest case series in the literature. CONCLUSION: Arterial dissection may be a complication from practicing sports.
Subject(s)
Athletic Injuries/complications , Carotid Artery, Internal, Dissection/etiology , Recreation , Sports/statistics & numerical data , Vertebral Artery Dissection/etiology , Adolescent , Adult , Aged , Carotid Artery, Internal, Dissection/pathology , Cerebral Angiography , Female , Headache/etiology , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors , Stroke/etiology , Vertebral Artery Dissection/pathology , Young AdultABSTRACT
OBJECTIVE: To describe characteristics and provision of care for patients admitted with cerebrovascular disorders (CVD), focusing on ischemic stroke (IS), in a large, public, academic hospital in São Paulo, Brazil. METHOD: We retrieved information about 357 patients with CVD admitted to the Neurology Emergency Department (NED) and Neurology Ward (NW) of our institution. We described patient characteristics and management of IS in NED and in NW. RESULTS: IS was diagnosed in 79.6% of CVD patients admitted to NED; 2.7% were submitted to thrombolysis. Extent of IS investigation and management were significantly different in NED and NW. CONCLUSION: IS patients in our center were younger than in developed countries. IS management was significantly influenced by patient characteristics. This information can aid in planning strategies to decrease stroke burden.
Subject(s)
Emergency Medical Services/standards , Hospitalization/statistics & numerical data , Outcome and Process Assessment, Health Care , Stroke/drug therapy , Thrombolytic Therapy , Adolescent , Adult , Aged , Brazil/epidemiology , Developed Countries , Emergency Medical Services/statistics & numerical data , Emergency Service, Hospital , Epidemiologic Methods , Female , Hospitals, University , Humans , Ischemic Attack, Transient/drug therapy , Male , Middle Aged , Stroke/epidemiology , Young AdultABSTRACT
OBJECTIVE: To describe characteristics and provision of care for patients admitted with cerebrovascular disorders (CVD), focusing on ischemic stroke (IS), in a large, public, academic hospital in São Paulo, Brazil. METHOD: We retrieved information about 357 patients with CVD admitted to the Neurology Emergency Department (NED) and Neurology Ward (NW) of our institution. We described patient characteristics and management of IS in NED and in NW. RESULTS: IS was diagnosed in 79.6 percent of CVD patients admitted to NED; 2.7 percent were submitted to thrombolysis. Extent of IS investigation and management were significantly different in NED and NW. CONCLUSION: IS patients in our center were younger than in developed countries. IS management was significantly influenced by patient characteristics. This information can aid in planning strategies to decrease stroke burden.
OBJETIVO: Descrever características e manejo de pacientes internados com diagnóstico de doença cerebrovascular (DCV), enfocando principalmente o acidente vascular cerebral isquêmico (AVCI), em um hospital público universitário em São Paulo. MÉTODO: Coletamos informações de 357 pacientes com DCV internados no Pronto-Socorro de Neurologia (PSN) e na Enfermaria de Neurologia (EN) de nossa instituição. Descrevemos características dos pacientes e manejo do AVCI no PSN e na EN. RESULTADOS: O AVCI foi diagnosticado em 79,6 por cento dos pacientes com DCV admitidos no PSN; 2,7 por cento foram submetidos a trombólise. A extensão da investigação e o manejo da doença foram significativamente diferentes no PSN e na EN. CONCLUSÃO: os pacientes com AVCI em nosso centro foram mais jovens que em países desenvolvidos. O manejo do AVCI foi influenciado significativamente pelas características dos pacientes. Estas informações podem auxiliar no planejamento de estratégias para diminuir as conseqüências das DCV em nosso meio.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Emergency Medical Services/standards , Hospitalization/statistics & numerical data , Outcome and Process Assessment, Health Care , Stroke/drug therapy , Thrombolytic Therapy , Brazil/epidemiology , Developed Countries , Emergency Service, Hospital , Epidemiologic Methods , Emergency Medical Services/statistics & numerical data , Hospitals, University , Ischemic Attack, Transient/drug therapy , Stroke/epidemiology , Young AdultABSTRACT
O acometimento do sistema nervoso central pela tuberculose pode se manifestar de duas formas principais: tuberculose meníngea ou tuberculoma. Esta forma é uma condição que vinha decrescendo progressivamente, mas que encontrou nos dias atuais condições ideais para o seu desenvolvimento. O presente estudo discorre sobre três pacientes que desenvolveram expansão paradoxal de lesões de tuberculose cerebral durante o uso de tuberculostáticos, o que demonstra ser importante o acompanhamento tomográfico de pacientes que apresentem sinais neurológicos no curso do tratamento para a tuberculose. Os dois primeiros pacientes apresentaram o acometimento neurológico associado a tuberculose pulmonar, enquanto no terceiro havia história de tuberculose meníngea prévia. A tomografia computadorizada foi o exame utilizado para o acompanhamento desses pacientes. O tratamento constou do uso de tuberculostáticos e corticóides.
