ABSTRACT
ABSTRACT We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .
RESUMO Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.
Subject(s)
Humans , Cognitive Behavioral Therapy , Dementia , Electric Stimulation , Alzheimer DiseaseABSTRACT
This study investigated the performance of Frequency Specific Auditory Steady-State Response (FS-ASSR) detection elicited by the amplitude modulated tone with 2-order exponential envelope (AM2), using objective response detection (ORD) techniques of Spectral F-Test (SFT) and Magnitude Squared Coherence (MSC). ASSRs from 24 normal hearing adults were obtained during binaural multi-tone stimulation of amplitude-modulation (AM) and AM2 at intensities of 60, 45 and 30 dBSPL. The carrier frequencies were 500, 1000, 2000, and 4000 Hz, modulated between 77 and 105 Hz. AM2 achieve FS-ASSR amplitudes higher than AM by 16%, 18% and 12% at 60, 45 and 30 dBSPL, respectively, with a major increase at 500 Hz (22.5%). AMS2PL increased the Detection Rate (DR) up to 8.3% at 500 Hz for 30 dBSPL, which is particularly beneficial for FS-ASSR detection near the hearing threshold. In addition, responses in 1000 and 4000 Hz were consistently increased. The MSC and SFT presented no differences in Detection Rate (DR). False Detection Rate (FDR) was close to 5% for both techniques and tones. Detection times to reach DR over 90% were 3.5 and 4.9 min at 60 and 45 dBSPL, respectively. Further investigation concerning efficient multiple FS-ASSR is still necessary, such as testing subjects with hearing loss.
Subject(s)
Acoustic Stimulation/methods , Evoked Potentials, Auditory/physiology , Adolescent , Adult , Electroencephalography , Humans , Signal Processing, Computer-Assisted , Young AdultABSTRACT
We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .
Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.
