ABSTRACT
Experiments were conducted to evaluate the effects of amphetamine (0. 4 mg/kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in Balb/c female mice. Enhancement of MSV-induced tumor incidence and tumor growth was observed, together with a delay in the usual prompt regression of the tumors, when mice were daily injected with amphetamine for 3 days after MSV-inoculation. However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation.
Subject(s)
Adrenergic Agents/pharmacology , Amphetamine/pharmacology , Moloney murine sarcoma virus , Retroviridae Infections/pathology , Sarcoma, Experimental/pathology , Tumor Virus Infections/pathology , Animals , Female , Immunity, Cellular/drug effects , Injections, Subcutaneous , Mice , Mice, Inbred BALB C , Premedication , Retroviridae Infections/drug therapy , Sarcoma, Experimental/drug therapy , Tumor Virus Infections/drug therapyABSTRACT
Mice injected with amphetamine showed a dose-related suppression of the natural killer cell activity. The capacity of T-cells to generate cytotoxic T-lymphocytes (CTL) in mixed lymphocyte cultures and in vivo was also assayed and amphetamine was found to inhibit CTL responses.
