Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial.

BACKGROUND AND PURPOSE: Cancer is a frequent finding in ischaemic stroke patients. The frequency of cancer amongst participants in the NAVIGATE ESUS randomized trial and the distribution of outcome events during treatment with aspirin and rivaroxaban were investigated. METHODS: Trial participation required a recent embolic stroke of undetermined source. Patients' history of cancer was recorded at the time of study entry. During a mean follow-up of 11 months, the effects of aspirin and rivaroxaban treatment on recurrent ischaemic stroke, major bleeding and all-cause mortality were compared between patients with cancer and patients without cancer. RESULTS: Amongst 7213 randomized patients, 543 (7.5%) had cancer. Of all patients, 3609 were randomized to rivaroxaban [254 (7.0%) with cancer] and 3604 patients to aspirin [289 (8.0%) with cancer]. The annual rate of recurrent ischaemic stroke was 4.5% in non-cancer patients in the rivaroxaban arm and 4.6% in the aspirin arm [hazard ratio (HR) 0.98, 95% confidence interval (CI) 0.78-1.24]. In cancer patients, the rate of recurrent ischaemic stroke was 7.7% in the rivaroxaban arm and 5.4% in the aspirin arm (HR 1.43, 95% CI 0.71-2.87). Amongst cancer patients, the annual rate of major bleeds was non-significantly higher for rivaroxaban than aspirin (2.9% vs. 1.1%; HR 2.57, 95% CI 0.67-9.96; P for interaction 0.95). All-cause mortality was similar in both groups. CONCLUSIONS: Our exploratory analyses show that patients with embolic stroke of undetermined source and a history of cancer had similar rates of recurrent ischaemic strokes and all-cause mortality during aspirin and rivaroxaban treatments and that aspirin appeared safer than rivaroxaban in cancer patients regarding major bleeds. www.clinicaltrials.gov (NCT02313909).

Carotenoid and mineral content of different morphotypes of Centella asiatica L. (Gotukola).

Six morphotypes of Centella asiatica designated G(1), G(2), G(3), G(7), G(8) and G(12) were analyzed for carotenoid content, proximate components and selected dietary minerals. Potassium was found to be the major element present in C. asiatica and the content in G(1) and G(3) (6,165.0 ± 125.8 mg/100 g dry weight) was significantly (P < 0.05) higher than all other morphotypes. C. asiatica is more popular for its higher contents of iron and calcium. However, no significant (P>0.05) differences in calcium content among the morphotypes were observed. The imported variety G(7) had significantly higher (P < 0.05) mean content of iron (74.3 ± 34.1 mg/100 g dry weight). The morphotypes G(8) and G(12) contained significantly higher (P < 0.05) content of ß-carotene (77.2 ± 5.1 µg/g fresh weight) and lutein (133.5 ± 10.1 µg/g, fresh weight) respectively. Lutein and ß-carotene levels of these two types were also significantly higher (P < 0.05) than those in the other varieties. The study did not provide any evidence to believe that a given morphotype is superior to another in its overall nutritional value.

Effect of supplemental light on growth, prolactin, progesterone and luteinizing hormone in water buffalo (Bubalus bubalis).

Fifty non-pregnant Surti buffalo heifers aged between 17 and 42 months (n = 24, less than 24 months; n = 26, greater than 24 months) were randomly assigned to groups subject to either natural daylight +4 h supplemental light (n = 25) or natural day light (n = 25), to study changes in growth, serum prolactin (Prl), progesterone (P4) and luteinizing hormone (LH) to supplemental lighting. Ambient temperatures (T) and relative humidity (RH) generally were greater than 27 degrees C and less than 70% during the daytime, respectively. Light-supplemented heifers had 16.2 kg net body weight (BW) gain at 9 weeks compared to 20.8 kg for controls, but higher mean Prl after 6.5 weeks (P less than 0.01), and higher P4 (0.41 vs 0.19 ng/ml; P less than 0.06) than control heifers. Older heifers had 39.7% greater BW (P less than 0.01), but a net 4.3% BW gain compared to a 10.1% gain for younger heifers at 10 weeks. Older, light-supplemented heifers had higher mean P4 (0.63 vs 0.19 ng/ml; P less than 0.07) than the other groups. These weight and hormonal changes suggest that 4 h supplemental light can alter growth and endocrine function in buffaloes under similar planes of nutrition. While light supplementation did not have a positive effect on body weight during the 10 week study, body weight and endocrine changes due to supplemental light may be important factors for initiation of reproductive cyclicity.

Effect of season and stage of lactation on plasma insulin and glucose following glucose injection in Holstein cattle.

Changes in plasma glucose and insulin concentrations following glucose injection in dairy cows (six per stage of lactation per season) were characterized during early, middle, and late lactation in winter, spring, and summer. Blood samples were collected 60, 45, 30, 20, 15, 10, 5, and 0 min (period 1) before glucose injection (.1 g/kg body weight) and at 5, 10, 15, 20, 30, 45, and 60 min (period 2) after injection. Plasma insulin concentrations were affected by season, period, season by period interaction, and time within period. Plasma glucose was affected by period, time within period, and stage of lactation by period interaction. Insulin was lowest in summer. Magnitude of insulin response to glucose was highest in spring. Both plasma glucose and insulin increased significantly 5 min following glucose injection. Peak glucose concentrations increased with advancing lactation. Results indicate alterations in glucose metabolism as well as changes in insulin sensitivity to glucose in various seasons and stages of lactation.

Utilization of primary health care workers for early detection of oral cancer and precancer cases in Sri Lanka.

Oral cancer presents a serious public health problem in south-east Asian countries. In Sri Lanka and India 35-40% of all cancers are reported to be oral cancers, which are curable if detected in the early stages. The idea that, in developing countries, one of the few practical approaches to early detection of these cases could be through the utilization of primary health care workers was tested in a field study carried out in Sri Lanka. In a control area the subjects with oral lesions were identified by medical/dental officers. In the study, 34 primary health care workers were able, alongside their routine duties, to examine the oral cavity of 28 295 subjects during a period of 52 weeks; 1220 subjects were detected with lesions needing re-examination. The performance of these primary health care workers was very satisfactory in terms of the number of cases detected and the accuracy of their diagnoses, which were verified by re-examination at a specially designated referral centre. The clinical diagnoses of the three categories of lesions detected were as follows: stage 1 lesions for observation (homogeneous or ulcerated leukoplakia), stage 2 lesions for investigation (speckled leukoplakia, erythroplakia, or submucous fibrosis), and stage 3 lesions for treatment (cancer). There was 89% correspondence between the stage 1-3 diagnoses by the health workers and the clinical diagnoses made at the referral centre. However, compliance by patients was low because only 50% of the cases detected in the field attended the referral centre. The cost-effectiveness of this approach to cancer control has been demonstrated.