ABSTRACT
Cytogenetic monitoring of workers of large industrial enterprizes showed the presence of chromatide aberrations in the peripheral blood lymphocytes, which were more manifest in workers of chemical and byproduct cokeplants, and somewhat less apparent in metallurgists. The frequency of metaphases involving chromosomal aberrations is dependent upon the duration of occupational exposure to chemical mutagens. However, the number of chromosomal abberrations does not appear to be influenced by chemical factors remaining essantially the same. The human embrion genome sensitivity to the chemical mutagen action was found to be much higher than that of somatic cells of the adults occupationally exposed to alterating factors. Use of complexes of antioxidants (tocopheroli acetas, quercetin, splenin) makes for reduction in the number of chromosomal aberrations in workers engaged in chemical industry.
Subject(s)
Chemical Industry , Chromosome Aberrations/genetics , Coke , Metallurgy , Occupational Exposure/adverse effects , Adult , Humans , Metaphase , Middle Aged , Occupational Exposure/statistics & numerical data , Time Factors , UkraineABSTRACT
It has been detected that children evacuated from the zone with the elevated radioactivity level have the increased number of chromosomal and chromatid aberrations. The frequency of chromatid aberrations is 2.1-fold lower in country-side children than in children from industrial towns. Cytogenetic disturbances in immunocompetent cells correlate with the level of immune imbalance. Children born in families of liquidators of the ChNPP accident in the first year after their return from the accident zone have substantial cytogenetic and immune disturbances. Children living near sources of atmospheric pollution are characterized by the 3-4-fold increase in frequencies of chromatid anomalies and by the development of a pronounced immunodeficiency.
