1.
J Antibiot (Tokyo)
; 50(9): 734-7, 1997 Sep.
Article
in English
| MEDLINE
| ID: mdl-9360617
ABSTRACT
A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.
Subject(s)
Anti-Bacterial Agents/isolation & purification , Antibiotics, Antineoplastic/isolation & purification , Depsipeptides , Peptides , Animals , Anti-Bacterial Agents/pharmacology , Antibiotics, Antineoplastic/pharmacology , Fermentation , Leukemia P388/drug therapy , Microbial Sensitivity Tests , Micromonospora , Tumor Cells, Cultured/drug effects
2.
J Antibiot (Tokyo)
; 50(9): 738-41, 1997 Sep.
Article
in English
| MEDLINE
| ID: mdl-9360618
ABSTRACT
Thiocoraline (1) is a new antitumor antibiotic isolated from the mycelium of Micromonospora sp. L-13-ACM2-092. Its structure was elucidated to be a novel cyclic thiodepsipeptide on the basis of spectroscopic methods.
Subject(s)
Anti-Bacterial Agents/chemistry , Antibiotics, Antineoplastic/chemistry , Depsipeptides , Peptides , Molecular Structure
3.
J Antibiot (Tokyo)
; 50(2): 175-6, 1997 Feb.
Article
in English
| MEDLINE
| ID: mdl-9099230