ABSTRACT
PURPOSE OF INVESTIGATION: To determine the accuracy of carcinoembryonic antigen (CEA), cancer antigen (CA) 15.3, CA 19.9, and CA 125 for diagnosis of mucinous ovarian cancer (MOC). MATERIALS AND METHODS: Samples were collected preoperatively from patients with mucinous ovarian tumor. The following variables were analysed: CEA, CA 15.3, CA 19.9, and CA 125. After surgery, histology and stage were determined according to FIGO-classification. Patients were classified into two groups according to the diagnosis of ovarian biopsy: NOT MOC and MOC. RESULTS: The authors studied 94 patients with ages between 15 and 80 years (median = 43). Eighty-two patients were NOT MOC (68 mucinous ovarian cystadenomas and 14 mucinous borderline ovarian tumors) and 12 were MOC. All MOC patients were in FIGO Stages I or II. No statistically significant differences were found between MOC and NOT MOC patients according to CEA and CA 15.3 (p > 0.05). All MOC patients had abnormal serum CA 19.9 and/or CA 125 levels. Using CA 19.9 and CA 125, we performed a linear regression formula CA 19.9+125 = 0.00102 x CA 19.9 + 0.00057 x CA 125. AUCs values were 0.862 (p = 0.0002), 0.829 (p = 0.0021), and 0.911 (p = 0.0001) for CA 19.9, CA 125, and CA 19.9 + 125, respectively. CA 19.9 + 125 exhibited 95.1% specificity and 66.7% sensitivity, increased by 16.7% sensitivity compared with using only CA 19.9 or CA 125. CONCLUSIONS: Preoperative CA 19.9 and CA 125 levels showed high diagnosis efficacy to predict whether a mucinous ovarian tumour is benign or malignant. Using both markers simultaneously increases the sensitivity for diagnosis of MOC.
Subject(s)
Adenocarcinoma, Mucinous/diagnosis , CA-125 Antigen/blood , CA-19-9 Antigen/blood , Ovarian Neoplasms/diagnosis , Adenocarcinoma, Mucinous/blood , Adenocarcinoma, Mucinous/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Carcinoembryonic Antigen/analysis , Female , Humans , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/blood , Ovarian Neoplasms/pathology , Young AdultABSTRACT
Estudiamos 182 pacientes diagnosticados de tuberculosis con el fin de conocer la incidencia de multirresistencia en la Bahía de Cádiz. Las cepas responsables, 173 Mycobacterium tuberculosis y 9 M. hovis, se identificaron mediante hibridación con sondas y técnicas moleculares de RFLP (restriction fragment length Poli morphism) y spoligotyping (spacer oligonucle olido typing). Se detectó algún tipo de resistencia en 51 pacientes (28,0 por ciento), primaria en el 20,9 por ciento y secundaria en el 7, I por ciento. Encontramos cepas multirresistentes en un 12,6 por ciento de pacientes (23,1 por ciento VIII positivos v 8,5 por ciento VIH negativos). La tasa de multirresistencia en Cádiz es superior a las detectadas en otras zonas de España y se asocia preferentemente con infección por el virus de la inmunodeficiencia humana (AU)
