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Content of HLA-G(+) T Cells in the Peripheral Blood from Healthy Women and Breast Cancer Patients.

Ostapchuk, E O; Perfi L'eva, Yu V; Talaeva, Sh Zh; Omarbaeva, N A; Belyaev, N N.

Bull Exp Biol Med ; 159(5): 649-51, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26468020

ABSTRACT

The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to suppression of antitumor immunity.

Subject(s)

Breast Neoplasms/immunology , HLA-G Antigens/immunology , Immunity, Innate , T-Lymphocyte Subsets/immunology , Adult , Breast Neoplasms/genetics , Breast Neoplasms/pathology , CD3 Complex/genetics , CD3 Complex/immunology , CD56 Antigen/genetics , CD56 Antigen/immunology , Case-Control Studies , Female , Flow Cytometry , Gene Expression , HLA-G Antigens/genetics , Humans , Immunophenotyping , Interferon-gamma/genetics , Interferon-gamma/immunology , Interleukin-10/genetics , Interleukin-10/immunology , Lymphocyte Count , Middle Aged , Neoplasm Staging , T-Lymphocyte Subsets/pathology , Transforming Growth Factor beta/genetics , Transforming Growth Factor beta/immunology

ABSTRACT

Subject(s)

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