ABSTRACT
Ketoprofen lysine salt (Artrosilene) Fiale) is a non-steroidal anti-inflammatory agent frequently administered by intravenous infusion in association regimen with other drugs, such as steroidal anti-inflammatory, anti-hemorrhagic, anti-spastic, anti-ulcer, and antibacterial drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene) Fiale) and other injectable drugs frequently used in association. Physicochemical properties of ketoprofen lysine salt mixtures with different drugs, including colour, clarity, pH and drug content were observed or measured before and after (up to 5 h) mixing at room temperature and under light protection. Results show that the association of Artrosilene Fiale with different drugs does not cause, up to 5 h from mixing, any significant variation in the physicochemical parameters mentioned above. In conclusion, the results obtained demonstrated the physicochemical compatibility of ketoprofen lysine salt (Artrosilene) Fiale) with several drugs.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemistry , Ketoprofen/analogs & derivatives , Ketoprofen/chemistry , Lysine/analogs & derivatives , Lysine/chemistry , Pharmaceutical Preparations/chemistry , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Chromatography, High Pressure Liquid , Hydrogen-Ion Concentration , Injections, Intravenous , Ketoprofen/administration & dosage , Lysine/administration & dosage , Spectrophotometry, UltravioletABSTRACT
Thiocolchicoside (Miotens), a muscle relaxant agent, is frequently administered in association regimen with other drugs, such as anti-inflammatory drugs or vitamins. The aim of this study was to investigate the physicochemical compatibility between thiocolchicoside (Miotens) and other injectable drugs frequently used in association. Physicochemical properties of thiocolchicoside mixtures with different drugs, including colour, clarity, pH and drug content were observed or measured before and after (3 h) mixing at room temperature. Results show that the association of Miotens with different anti-inflammatory drugs and vitamins does not cause, up to 3 h from mixing, any significant variation in the physicochemical parameters mentioned above. In conclusion the results obtained demonstrated the physicochemical compatibility of thiocolchicoside (Miotens) with diverse anti-inflammatory drugs and vitamins.
