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1.
J Clin Med ; 12(11)2023 May 29.
Article in English | MEDLINE | ID: mdl-37297943

ABSTRACT

The risk/benefit ratio of using prothrombin complex concentrates (PCCs) to correct coagulation defects in patients with end-stage liver disease is still unclear. The primary aim of this review was to assess the clinical effectiveness of PCCs in reducing transfusion requirements in patients undergoing liver transplantation (LT). This systematic review of non-randomized clinical trials was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The protocol was previously registered (PROSPERO:CRD42022357627). The primary outcome was the mean number of transfused units for each blood product, including red blood cells (RBCs), fresh frozen plasma, platelets, and cryoprecipitate. Secondary outcomes included the incidence of arterial thrombosis, acute kidney injury, and haemodialysis, and hospital and intensive care unit length of stay. There were 638 patients from 4 studies considered for meta-analysis. PCC use did not affect blood product transfusions. Sensitivity analysis, including only four-factor PCC, showed a significant reduction of RBC effect size (MD: 2.06; 95%CI: 1.27-2.84) with no true heterogeneity. No significant differences in secondary outcomes were detected. Preliminary evidence indicated a lack of PCC efficacy in reducing blood product transfusions during LT, but further investigation is needed. In particular, future studies should be tailored to establish if LT patients will likely benefit from four-factor PCC therapy.

4.
Article in English | MEDLINE | ID: mdl-33638622

ABSTRACT

BACKGROUND: Chlorhexidine is a synthetic biguanide with a broad antibacterial activity and has become an important cause of perioperative anaphylaxis. OBJECTIVE: Reactions due to chlorhexidine allergy are usually IgE-mediated. The aim of this report is to demonstrate utility of laboratory in-vitro testing for diagnosis. METHODS: We report the case of a 36-year old man who experienced severe anaphylaxis during general anesthesia. He underwent skin tests, specific detection of specific IgE to chlorhexidine and basophil activation test (BAT). RESULTS: Skin tests gave false positive results due to dermographism. So, on the basis of a clinical reaction to chlorhexidine and positive tests for IgE to chlorexidine and BAT, we assessed the diagnosis of chlorhexidine allergy. CONCLUSIONS: Physicians should be aware of the role of chlorhexidine in the etiology of perioperative anaphylaxis. In vitro testing such specific IgE and BAT are useful in patient with suspected chlorexidine allergy and limitation to perform skin tests.

5.
Minerva Anestesiol ; 86(9): 957-964, 2020 09.
Article in English | MEDLINE | ID: mdl-32251573

ABSTRACT

INTRODUCTION: It has been hypothesized that routine use of deep neuromuscular block (dNMB) is advisable in laparoscopic bariatric surgery to optimize workspace conditions. dNMB seems to have advantages in laparoscopic procedures on non-obese patients as it improves surgical space conditions and reduces postoperative pain scores. This systematic review and meta-analysis aimed at comparing the impact of deep vs. moderate NMB (mNMB) on surgical conditions and outcomes, including duration of surgery and postoperative pain in patients undergoing laparoscopic bariatric surgery. EVIDENCE ACQUISITION: Studies were identified from Medline, Embase and Cochrane library (update: Sep 1, 2019). Randomized controlled trials (RCTs) comparing dNMB with mNMB were identified if they reported surgeon satisfaction for workspace conditions (primary outcome). The effects of dNMB on surgery duration and postoperative pain (secondary outcomes) were also investigated. EVIDENCE SYNTHESIS: Of the 45 retrieved records, four were finally included. dNMB improved the surgeon's satisfaction score about workspace (on a scale ranging from 1 to 5), with a mean difference (MD) of 0.52 (95% CI: 0.36-0.68). Surgical duration was not affected by block level (MD: -3.29 minutes; 95% CI: from -14.35 to 7.76). Only one study showed that dNMB also decreased postoperative pain. CONCLUSIONS: It was found that dNMB helps improve surgical space conditions in patients undergoing laparoscopic bariatric surgery whereas it fails to shorten procedure duration. More high-quality large-sampled RCTs are needed to confirm these results. The relationship between dNMB use and other clinical outcomes, such as complications occurrence, needs to be further investigated.


Subject(s)
Bariatric Surgery , Laparoscopy , Neuromuscular Blockade , Humans , Pain, Postoperative , Randomized Controlled Trials as Topic
6.
Transplant Proc ; 52(5): 1585-1587, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32217008

ABSTRACT

INTRODUCTION: The aim of this retrospective study was to evaluate any relationship between cardiac power index (CPI) and preload indexes during liver transplantation (LT). METHODS: Thirty-three patients with normal preoperative cardiac evaluation undergoing LT were included. Anesthesia management was standardized. Monitoring included continuous cardiac output determination by pulmonary artery catheter. CPI was calculated throughout LT by using the following standard formula: Mean Arterial Pressure [mm Hg] × Cardiac Index [L/min/m2] × k, where k = 0.0022. A logistic regression to determine which preload indexes predicted an adequate CPI (≥ 0.4 watt/m2) was performed. Postregression analysis was carried out to calculate a cutoff of right ventricle end diastolic volume index (RVEDVI) able to guarantee an adequate CPI after establishing a sensitivity >0.9. The area under receiver operating characteristic curve (AUC) was also run separately for patients with a Model for End-Stage Liver Disease (MELD) score < or ≥ 25 to establish an accurate level of prediction in these subgroups (post-hoc analysis). RESULTS: Logistic regression showed that RVEDVI was the only predictor of CPI (AUC = 0.81). A cutoff value for RVEDVI of 105 mL/m2 was found (sensitivity = 90.5%; specificity = 50%). RVEDVI predicted CPI with moderate accuracy (AUC = 0.80) in patients with MELD < 25 (n = 25), whereas the prediction was highly accurate (AUC = 0.96) in patients with MELD ≥ 25 (n = 8). CONCLUSION: An RVEDVI = 105 mL/m2 can be considered a valid cutoff to perform a fluid challenge to optimize preload during LT. Sicker recipients (with MELD ≥ 25) could exhibit less tolerance to preload reduction, proven by a decrease of CPI below the minimum value considered safe (0.40 watt/m2).


Subject(s)
Cardiac Output/physiology , End Stage Liver Disease/physiopathology , End Stage Liver Disease/surgery , Liver Transplantation , Adult , Aged , Catheterization, Swan-Ganz , Female , Hemodynamics , Humans , Logistic Models , Male , Middle Aged , Monitoring, Physiologic , Predictive Value of Tests , ROC Curve , Retrospective Studies
8.
Eur J Anaesthesiol ; 37(11): 1066-1074, 2020 11.
Article in English | MEDLINE | ID: mdl-31860600

ABSTRACT

BACKGROUND: Postoperative cognitive decline (pCD) occurs frequently (6 to 30%) after carotid endarterectomy (CEA), although there are no exact estimates and risk factors are still unclear. OBJECTIVE: The objective of this study was to determine pCD incidence and risk factors in CEA patients. DESIGN: We performed a systematic review and meta-analysis of both randomised and nonrandomised trials following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. DATA SOURCES: We searched Cochrane, PubMed/Medline and Embase databases from the date of database inception to 1 December 2018. ELIGIBILITY CRITERIA: We selected longitudinal studies including CEA patients with both pre-operative and postoperative cognitive assessments. Primary outcome was pCD incidence, differentiating delayed neurocognitive recovery (dNCR) and postoperative neurocognitive disorder (pNCD). dNCR and pNCD incidences were expressed as proportions of cases on total CEA sample and pooled as weighted estimates from proportions. Postoperative delirium was excluded from the study design. Secondary outcomes were patient-related (i.e. age, sex, diabetes, hypertension, contralateral stenosis, pre-operative symptoms, dyslipidaemia and statin use) and procedure-related (i.e. hyperperfusion, cross-clamping duration and shunting placement) risk factors for pCD. We estimated odds ratios (ORs) and mean differences through a random effects model by using STATA 13.1 and RevMan 5.3. RESULTS: Our search identified 5311 publications and 60 studies met inclusion criteria reporting a total of 4823 CEA patients. dNCR and pNCD incidence were 20.5% [95% confidence interval (CI), 17.1 to 24.0] and 14.1% (95% CI, 9.5 to 18.6), respectively. pCD risk was higher in patients experiencing hyperperfusion during surgery (OR, 35.68; 95% CI, 16.64 to 76.51; P < 0.00001; I = 0%), whereas dNCR risk was lower in patients taking statins before surgery (OR, 0.56; 95% CI, 0.41 to 0.77; P = 0.0004; I = 19%). Sensitivity analysis revealed that longer cross-clamping duration was a predictor for dNCR (mean difference, 5.25 min; 95% CI, 0.87 to 9.63; P = 0.02; I = 49%). CONCLUSION: We found high incidences of dNCR (20.5%) and pNCD (14.1%) after CEA. Hyperperfusion seems to be a risk factor for pCD, whereas the use of statins is associated with a lower risk of dNCR. An increased cross-clamping duration could be a risk factor for dNCR. TRIAL REGISTRATION: This systematic review was registered in the International Prospective Register of Systematic Reviews (CDR42017073633).


Subject(s)
Cognitive Dysfunction , Endarterectomy, Carotid , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Endarterectomy, Carotid/adverse effects , Humans , Odds Ratio , Risk Factors
10.
Exp Clin Transplant ; 17(5): 575-579, 2019 10.
Article in English | MEDLINE | ID: mdl-30806201

ABSTRACT

OBJECTIVES: Delayed graft function is a frequent complication in deceased-donor kidney transplant, with an incidence ranging from 10% to 50% among different centers; it is also associated with lower graft survival. In this study, we aimed to identify risk factors for delayed graft function, particularly those associated with perioperative management (including cold ischemia time) and nonmodifiable recipient- and donor-related factors. The effects of delayed graft function on graft and patient outcomes were also evaluated. MATERIALS AND METHODS: Our retrospective analyses included 125 adult patients who underwent deceased-donor kidney transplant. Delayed graft function was diagnosed if at least 1 dialysis treatment was required during the first week posttransplant according to Perico's definition. RESULTS: Prevalence of delayed graft function was 30.4% (n = 38). Cold ischemia time was significantly prolonged in patients with delayed graft function compared with those without it. Multivariate regression showed that cold ischemia time was the only predictor of delayed graft function. A cutoff of 9 hours and 12 minutes was found as a limit beyond which delayed graft function occurred (sensitivity = 90%; specificity = 29%; area under the curve = 0.68). Greater donor and recipient age and longer pretransplant dialysis time in recipients were associated with occurrence of delayed graft function. In patients with delayed graft function, hospital stay duration was significantly greater and 1-year graft survival was significantly lower. CONCLUSIONS: Efforts should be focused on limiting cold ischemia time and associated injury to reduce occurrence of delayed graft function and consequently improve long-term graft survival in kidney transplant recipients. Optimization of posttransplant renal function with the help of new technologies, such as pulsatile perfusion, could be crucial for minimization of cold ischemia time.


Subject(s)
Delayed Graft Function/etiology , Kidney Transplantation , Adult , Aged , Cold Ischemia , Donor Selection , Female , Humans , Male , Middle Aged , Patient Selection , Preoperative Period , Retrospective Studies , Risk Factors
11.
Updates Surg ; 71(3): 543-547, 2019 Sep.
Article in English | MEDLINE | ID: mdl-30506468

ABSTRACT

Synchronous posterior retroperitoneoscopic bilateral adrenalectomy (PR-BilA) is a novel technique proposed for the definitive cure of hypercortisolism when a surgical approach is indicated. The aim of the present prospective cohort study was to compare the carbon dioxide (CO2) absorption in patients undergoing PR-BilA with those undergoing single posterior retroperitoneoscopic adrenalectomy (PRA). Twenty-nine patients undergoing PR-BilA or PRA were consecutively enrolled. Anaesthesia was standardised. In both groups, CO2 elimination (VCO2), CO2 dissolved in arterial blood (PaCO2), end-tidal CO2 (EtCO2), and volume per minute (VM) were measured at the following time points: after anaesthesia induction and before CO2 insufflation (T1), 5 min after CO2 insufflation (T2), at the time of maximum VCO2 (T3), and at desufflation (T4). VCO2 was continuously measured using a metabolic monitor. ANOVA for repeated measures was used for statistical analysis. With respect to VCO2, a significant group × time interaction was found (p = 0.03). Post hoc analysis revealed that VCO2 was significantly increased at T4 compared with T1 in both groups (p = 0.02 and p = 0.0001 in the PRA and PR-BilA groups, respectively). Regarding PaCO2, ANOVA analysis showed a significant group effect (p = 0.01), with higher values in the PR-BilA group. EtCO2 and VM did not differ between the two groups. We found that the CO2 absorption was increased in both groups at the end of surgery, in the presence of a higher trend in PaCO2 values during PR-BilA. Therefore, PR-BilA may be considered a safe surgical approach with respect to CO2 absorption, when a mild degree of hypercapnia may be accepted.


Subject(s)
Adrenalectomy/methods , Carbon Dioxide/metabolism , Adrenalectomy/adverse effects , Adult , Carbon Dioxide/blood , Cushing Syndrome/surgery , Endoscopy/methods , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Monitoring, Intraoperative , Operative Time , Prospective Studies , Retroperitoneal Space/surgery
12.
Gynecol Oncol ; 151(2): 299-305, 2018 11.
Article in English | MEDLINE | ID: mdl-30201234

ABSTRACT

BACKGROUND: Usefulness of intraoperative goal-directed hemodynamic management (GDHM) for patients without comorbidities is debated. After clinical implementation of a pulse contour analysis-guided GDHM protocol, which foresees early vasopressor use for recruiting unstressed volume, we conducted a matched-controlled analysis to explore its impact on the amount of fluids intraoperatively administered to patients without comorbidities who underwent extended abdominal surgery for ovarian cancer. METHODS: After 1:1 matching accounting for body mass index, oncologic disease severity and intraoperative blood losses, 22 patients treated according to this GDHM protocol were compared to a control group of 22 patients who had been managed according to the clinical decision of attending physicians, taken without advanced monitoring. Results are displayed as median[interquartile range]. RESULTS: All analyzed patients underwent radical hysterectomy, bilateral adnexectomy, bowel resection, peritonectomy and extended pelvic/periaortic lymphadenectomy; median length of surgery was 517[480-605] min in patients receiving GDHM and 507[480-600] min in control group. Intraoperatively, patients undergoing GDHM received less fluids (crystalloids 2950[2700-3300] vs. 5150[4700-6000] mL, p < 0.001; colloids 100[50-200] vs. 750[500-1000] mL, p < 0.001) and showed a trend to more frequent vasopressor administration (32 vs 9%, p = 0.13). Greater intraoperative diuresis (540[480-620] mL vs. 450[400-500] mL, p = 0.007), lower blood lactates at surgery end (1.5[1.1-2] vs. 4.1[3.3-5] mmol/L, p < 0.001), shorter time to bowel function recovery (1 [1, 2] vs. 4 [3-5] days, p < 0.001) and hospital discharge (7 [6-8] vs 12 [9-16] days, p < 0.0001) were detected in patients receiving GDHM. CONCLUSIONS: In high-tumor load gynaecological patients without comorbidities who receive radical and prolonged surgery, intraoperative use of this novel GDHM protocol helped limit fluids administration with safety.


Subject(s)
Early Goal-Directed Therapy/methods , Fluid Therapy/methods , Genital Neoplasms, Female/therapy , Adult , Cardiac Output , Case-Control Studies , Crystalloid Solutions , Cytoreduction Surgical Procedures/methods , Female , Genital Neoplasms, Female/blood , Genital Neoplasms, Female/physiopathology , Genital Neoplasms, Female/surgery , Hemodynamics , Humans , Intraoperative Care/methods , Isotonic Solutions/administration & dosage , Middle Aged , Monitoring, Physiologic/methods , Pilot Projects , Precision Medicine/methods , Stroke Volume
13.
Obes Surg ; 28(10): 3172-3176, 2018 10.
Article in English | MEDLINE | ID: mdl-29752664

ABSTRACT

BACKGROUND: Previous studies have focused on the role of deep neuromuscular blockade (NMB) in improving surgical conditions during laparoscopic bariatric surgery. However, a wide inter-individual variability has been noted. The aim of this study was to identify patient-related factors affecting surgeon satisfaction with the surgical space and surgery duration in laparoscopic bariatric surgery under deep NMB. METHODS: One hundred eighty-five patients scheduled for laparoscopic gastric bypass were enrolled. Anesthesia was standardized. A deep NMB was maintained together with fixed patient positioning (30 reverse Trendelenburg) and constant pneumoperitoneum pressure (14 mmHg) during the whole surgical procedure. Immediately after surgery, the surgeon was invited to state his satisfaction with the surgical space through a verbal numeric scale (VNS) ranging from 0 (extremely poor) to 10 (optimal). RESULTS: VNS score was negatively correlated with male gender (r = - 0.35; p = 0.0001), BMI (r = - 0.16; p = 0.03), and age (r = - 0.20; p = 0.008). Surgery duration was positively correlated with male gender (r = 0.27; p = 0.0003) and BMI (r = 0.22; p = 0.006). Multivariate linear regressions showed that lower VNS scores were predicted by male gender (p = 0.000001) and increased age (p = 0.009), and that a longer surgery duration was predicted by male gender (p = 0.0002). CONCLUSIONS: Findings showed that male gender and higher patient age were independent predictors of lower surgeon satisfaction with the workspace during laparoscopic bariatric surgery. Male gender also had a significant role in predicting longer surgery duration. The role of android obesity, which is more frequently associated with male gender, in affecting surgeon-perceived workspace conditions needs further investigation.


Subject(s)
Bariatric Surgery/methods , Laparoscopy/methods , Obesity, Morbid/surgery , Surgeons/statistics & numerical data , Humans , Job Satisfaction , Neuromuscular Blockade , Operating Rooms , Patient Positioning
14.
Minerva Anestesiol ; 84(10): 1142-1149, 2018 10.
Article in English | MEDLINE | ID: mdl-29405669

ABSTRACT

BACKGROUND: The role of postreperfusion lactate clearance in assessing graft function has not yet been investigated. The aim of this study was to examine whether lactate clearance, assessed in the postreperfusion phase, can predict poor graft function in liver transplant patients. METHODS: Seventy patients undergoing liver transplantation (LT) were enrolled. Standardized anesthesia and intraoperative monitoring were applied. The lactate levels measured immediately after venous reperfusion and six hours later were used to calculate lactate clearance by the following formula: [(reperfusion lactate - 6 h post-reperfusion lactate)/reperfusion lactate] ×100. Student's t-test was performed to evaluate differences in lactate clearance between patients with good and poor graft function. Logistic regression was used to assess predictors of poor graft function. RESULTS: Postreperfusion lactate clearance was lower in patients with poor graft function compared to those with good graft function (P=0.0007). Logistic regression showed that postreperfusion lactate clearance may represent an early predictor of poor graft function (area under receiver operating characteristic curve =0.83). A lactate clearance cut-off of 59.7% was found (90% sensitivity, 38.3% specificity). CONCLUSIONS: Postreperfusion lactate clearance may be useful for the early identification of poor graft function after LT. In patients with lactate clearance <59.7%, it could be useful to search for the underlying cause of poor graft function.


Subject(s)
Lactic Acid/metabolism , Liver Transplantation , Female , Humans , Intraoperative Period , Liver/metabolism , Liver/surgery , Male , Middle Aged , Prognosis , Reperfusion , Time Factors
15.
Physiol Behav ; 163: 1-6, 2016 09 01.
Article in English | MEDLINE | ID: mdl-27102708

ABSTRACT

BACKGROUND: Previous studies performed in non-obese patients undergoing elective surgery have revealed that psychological factors may affect postoperative analgesic requirements. The aim of this observational prospective study was to investigate the extent to which psychopathological dimensions, including anxiety, depression and alexithymia, may influence postoperative pain intensity and analgesics consumption using patient-controlled analgesia (PCA) in patients undergoing bariatric surgery. METHODS: 120 patients, aged 18-60years, with an ASA physical status I-II, undergoing gastric bypass were enrolled. Anxiety and depression Hamilton scales, and Toronto Alexithymia scale, were administered to patients on the day before surgery. General anesthesia was standardized. After awakening, a PCA pump with intravenous tramadol was immediately made available for a 36-hour postoperative analgesia. Visual analog scale at rest (VASr) and after coughing (VASi), and effective PCA requests number were postoperatively recorded. Pearson's correlations, Anova analyses and multiple linear regression were used for statistical purpose. RESULTS: Positive correlations were found between anxiety, depression, alexithymia and all pain indicators (p<0.01). Analyses of variance showed that anxious (p<0.001), depressed (p<0.001) and alexithymic (p<0.05) patients had high pain indicators. VASr and VASi were predicted by anxiety and depression (p<0.05), but not by alexithymia; effective PCA requests number was predicted by anxiety, depression and alexithymia (p<0.001). CONCLUSIONS: Obese patients with high depression, anxiety and alexithymia levels rated their pain as more intense and required a larger amount of tramadol. Pain perception intensity was predicted by anxiety and depression but not by alexithymia, whereas analgesics consumption was predicted by all the investigated psychopathological dimensions.


Subject(s)
Analgesics/therapeutic use , Bariatric Surgery/adverse effects , Pain Perception/drug effects , Pain, Postoperative/drug therapy , Pain, Postoperative/etiology , Pain, Postoperative/psychology , Adolescent , Adult , Anxiety Disorders/etiology , Depressive Disorder/etiology , Female , Humans , Male , Middle Aged , Pain Measurement , Principal Component Analysis , Psychiatric Status Rating Scales , Young Adult
16.
Gen Hosp Psychiatry ; 37(2): 109-15, 2015.
Article in English | MEDLINE | ID: mdl-25550172

ABSTRACT

OBJECTIVE: Postoperative cognitive dysfunction (POCD) in liver transplant (LT) recipients is defined as a "more than expected" postoperative deterioration in cognitive domains, including short-term and long-term memory, mood, consciousness and circadian rhythm. It is diagnosed, after exclusion of other neurological complications, by using specific neuropsychological tests that need preoperative baseline. The aim of this systematic review was to assess the prevalence of POCD after LT and to analyze patients' symptoms, type and timing of assessment used. METHODS: PubMed, MEDLINE and The Cochrane Li-brary were searched up from January 1986 to August 2014. Study eligibility criteria are as follows: prospective and retrospective studies on human adult subjects describing prevalence of POCD and/or its sequelae after LT episodes were included. RESULTS: Eighteen studies were identified. The timing of testing for POCD may vary between different studies and within the single study, ranging from 0.5 to 32 weeks. POCD occurs in up to 50% of LT recipient. CONCLUSION: Future studies should be focused on detecting preoperative and intraoperative factors associated to POCD in order to carry out appropriate strategies aimed at reducing this disabling health condition. Relationship between POCD and long-term outcome needs to be investigated.


Subject(s)
Cognition Disorders/etiology , Liver Transplantation/adverse effects , Postoperative Complications/etiology , Cognition Disorders/epidemiology , Humans , Liver Transplantation/statistics & numerical data , Postoperative Complications/epidemiology
17.
Indian J Anaesth ; 58(1): 25-9, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24700895

ABSTRACT

BACKGROUND: The use of suction catheter (SC) has been shown to improve success rate during ProSeal laryngeal mask airway (PLMA) insertion in expert users. AIMS: The aim of this study was to compare insertion of PLMA performed by untrained physicians using a SC or the digital technique (DT) in anaesthetised non-paralysed patients. METHODS: In this prospective randomised double-blind study, conducted in the operating setting, 254 patients (American Society of Anaesthesiologists I-II, aged 18-65 years), undergoing minor surgery were enrolled. Exclusion criteria were body mass index >35 kg/m(2), laryngeal or oesophageal varices, risk of aspiration or difficult face mask ventilation either referred or suspected (Langeron's criteria ≥2) and modified Mallampati classification score >2. Participants were randomly allocated to one of the two groups in which PLMA was inserted using DT (DT-group) or SC (SC-group). STATISTICAL ANALYSIS: Chi-square test with Yates' correction, Mann-Whitney U-test or Student's t-test were carried-out as appropriate. RESULTS: The final insertion success rate was greater in SC-groupcompared with DT-group 90.1% (n = 109) versus 74.4% (n = 99) respectively (P = 0.002). Mean airway leak pressure was higher in SC-group compared to DT-group (23.7 ± 3.9 vs. 21.4 ± 3.2 respectively; (P = 0.001). There were no differences in insertion time, post-operative airway morbidity and complications. CONCLUSION: The findings of this study suggest that SC-technique improves the success rate of PLMA insertion by untrained physicians.

18.
Surg Obes Relat Dis ; 9(5): 809-15, 2013.
Article in English | MEDLINE | ID: mdl-23810609

ABSTRACT

The well-known difficulties in airway management in obese patients are caused by obesity-related airways and respiratory changes. Anesthesiologists confront a number of troubles, including rapid oxygen desaturation, difficulty with laryngoscopy/intubation and mask ventilation, and increased susceptibility to the respiratory depressant effects of anesthetic drugs. Preoperative assessment of the airways in the obese should include examination of specific predictors of difficult mask ventilation other than those for difficult intubation. Difficulties in airway management are decreased after providing optimal preoxygenation and positioning ("ramped"). Other strategies may include availability of alternative airway management devices, including new video laryngoscopes that significantly improve the visualization of the larynx and thereby facilitate intubation. If awake intubation is mandatory, it may be performed with fibrobronchoscope after providing an adequate topical anesthesia and sedation with short-acting drugs, such as remifentanil. Succinylcholine for rapid sequence induction might be replaced by rocuronium where sugammadex is available for reversal. A complete reversal of neuromuscular block, measured by train-of-four monitoring, should be obtained before extubation, which requires a fully awake patient in the same position with airway equipment used for intubation.


Subject(s)
Airway Management/methods , Obesity/complications , Obesity/physiopathology , Humans , Risk Assessment
19.
Ann Hepatol ; 13(1): 54-9, 2013.
Article in English | MEDLINE | ID: mdl-24378266

ABSTRACT

UNLABELLED: INTRODUCTION. Splanchnic hypoperfusion appears to play a key role in the failure of functional recovery of the graft after orthotopic liver transplantation (LT). The aim of this study was to determine if alterations of tonometric parameters, which are related to splanchnic perfusion, could predict poor graft function in patients undergoing LT. MATERIALS AND METHODS: After Ethics Committee approval, 68 patients undergoing LT were enrolled. In all the patients, regional-arterial CO2 gradient (Pr-aCO2) was recorded; in addition, the difference between Pr-aCO2 recorded at anhepatic phase (T1) and at the end of surgery (T2) (T2- T1 = ΔPr-aCO2) was calculated. Poor graft function was determined on the basis of Toronto's classification 72 hours after LT. Student t-test and logistic regression analysis were used for statistical purpose. Results. ΔPr-aCO2 was significantly greater in patients with poor graft function (3.5 ± 13.2) compared to patients with good graft function (-5.8 ± 12.3) (p = 0.014). The logistic regression analysis showed that the ΔPr-aCO2 was able to predict the onset of poor graft function (p = 0.037). A value of ΔPr-aCO2 ≥ -4 was associated with poor graft function with a sensibility of 93.3% and a specificity of 42.3%. CONCLUSION. Our study suggests that the change of Pr-aCO2 may be a valuable index of graft dysfunction. Gastric tonometry might give early prognostic information on the graft outcome, and it may aid clinicians in planning a more strict follow-up and proper interventions in order to improve graft survival.


Subject(s)
Carbon Dioxide/metabolism , Gastric Mucosa/metabolism , Graft Survival , Liver Cirrhosis/surgery , Liver Transplantation , Liver/blood supply , Transplants/blood supply , Adult , Female , Gastric Mucosa/blood supply , Humans , Hydrogen-Ion Concentration , Logistic Models , Male , Manometry , Middle Aged , Prognosis , Splanchnic Circulation/physiology , Treatment Outcome
20.
Obes Surg ; 22(12): 1897-902, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23001571

ABSTRACT

BACKGROUND: The effectiveness of restrictive procedures has been inferior to that of malabsorbitive ones. Recent variants of restrictive procedures, i.e., gastric banding and sleeve gastrectomy, confirm the strive for more efficacious solutions with less complications. We investigated the balance between effectiveness and complications for a new restrictive procedure, a Transoral Endoscopic Vertical Gastroplasty (TOGa®) METHODS: Seventy-nine morbidly obese patients were submitted to one out of three surgical procedures: TOGa® (29 patients), laparoscopic gastric bypass (LRYGBP; 20 patients), and biliopancreatic diversion (BPD; 30 patients). Mean BMI were 41.7 (35.4-46.6), 44.8 (36.4-54), and 47.5 (41-60.3), respectively. All the patients reached a 2-year follow-up. RESULTS: In TOGa® group BMI, respectively at 12 and 24 months, was 34.5 and 35.5, with 44 and 48.3% of patients with BMI lower than 35. In LRYGBP group, BMI was 30.7 and 29.2 kg/m(2), with 80 and 85% of patients with BMI < 35. In BPD group, BMI was 30 and 29.6 kg/m(2), with 100 and 93.3% of patients with BMI < 35. In TOGa® group, 59% of patients with an initial BMI < 45 reached a BMI < 35, in comparison to 48% recorded in the whole group and to 14.3% in patients with initial BMI ≥ 45. CONCLUSIONS: In selected patients, TOGa®, was associated with good results after two years in terms of weight loss, even in comparison with LRYGBP and BPD. Minimal trauma, absence of complications, and short hospital stay justify this procedure for patients with low BMI.


Subject(s)
Biliopancreatic Diversion , Gastroplasty , Obesity, Morbid/surgery , Postoperative Complications/surgery , Weight Loss , Adult , Body Mass Index , Female , Follow-Up Studies , Humans , Italy/epidemiology , Male , Middle Aged , Obesity, Morbid/epidemiology , Patient Selection , Postoperative Complications/epidemiology , Time Factors , Treatment Outcome
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