ABSTRACT
INTRODUCTION: A decrease in weight velocity and feeding difficulties in infants may be caused by an inadequate caloric intake and underlying medical conditions. CASE DESCRIPTION: By focusing on four clinical cases, this article illustrates the temporary use of a special infant formula in orally-fed and enterally-fed infants with unsatisfactory weight gain and special medical conditions such as gastrointestinal and neurological disorders. The formula was a nutritionally complete hypercaloric infant formula containing partially hydrolyzed whey protein. It was used after full consideration of all feeding options including breastfeeding. CONCLUSION: Implementing appropriate feeding behaviors, adapted to age and potential comorbidities, is an essential prerequisite for therapeutic management. The use of a nutritionally complete hypercaloric infant formula can be helpful to manage unsatisfactory weight gain and feeding difficulties in infants.
Subject(s)
Energy Intake/physiology , Enteral Nutrition/methods , Failure to Thrive , Gastrointestinal Diseases , Infant Formula , Infant Nutrition Disorders , Nervous System Diseases , Weight Gain/physiology , Breast Feeding/methods , Child Development , Failure to Thrive/diet therapy , Failure to Thrive/etiology , Failure to Thrive/physiopathology , Failure to Thrive/psychology , Feeding Behavior/physiology , Female , Gastrointestinal Diseases/complications , Gastrointestinal Diseases/therapy , Humans , Infant , Infant Formula/analysis , Infant Formula/chemistry , Infant Nutrition Disorders/etiology , Infant Nutrition Disorders/prevention & control , Male , Nervous System Diseases/complications , Nervous System Diseases/therapy , Treatment OutcomeABSTRACT
The preparation of a number of derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2.3-dicarboximide with an expected anxiolytic activity.
Subject(s)
Anti-Anxiety Agents/chemical synthesis , Anti-Anxiety Agents/pharmacology , Bridged Bicyclo Compounds/chemical synthesis , Bridged Bicyclo Compounds/pharmacology , Hydrocarbons, Halogenated/chemical synthesis , Hydrocarbons, Halogenated/pharmacology , Animals , Drug Design , Indicators and Reagents , Magnetic Resonance Spectroscopy , Male , Motor Activity/drug effects , Rats , Spectrophotometry, InfraredABSTRACT
The preparation is described of a number of new N-substituted derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with potential anxiolytic activity.
Subject(s)
Anti-Anxiety Agents/chemical synthesis , Imides/chemical synthesis , Propranolol/analogs & derivatives , Propranolol/chemical synthesisABSTRACT
The preparation of a number of derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with an expected anxiolytic activity is described.
Subject(s)
Anti-Anxiety Agents/chemical synthesis , Bridged Bicyclo Compounds/chemical synthesis , Octanes/chemical synthesis , Antidepressive Agents/chemical synthesis , Chemical Phenomena , Chemistry, Physical , Indicators and Reagents , Magnetic Resonance SpectroscopyABSTRACT
Three derivatives of 1,4 dichloro-dibenzo[e,h]-bicyclo[2.2.3]octane-2,3-dicarboximide were examined by 13C CPMAS NMR. Low energy conformations were found by a semi-empirical AM1 approach, NMR shielding constants were calculated using the GIAO RHF method.
