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Bioorg Med Chem ; 10(1): 189-94, 2002 Jan.
Article in English | MEDLINE | ID: mdl-11738621

ABSTRACT

We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.


Subject(s)
Thyrotropin-Releasing Hormone/analogs & derivatives , Magnetic Resonance Spectroscopy , Mass Spectrometry , Thyrotropin-Releasing Hormone/chemical synthesis , Thyrotropin-Releasing Hormone/pharmacology
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