[Results of tamoxifen treatment in patients with advanced breast cancer]. / Wynik leczenia tamoksyfenem chorych na zaawansowanego raka sutka.

The results of advanced breast cancer therapy with tamoxifen have been evaluated. The objective response to the drug has been achieved in 32 (31.7%) patients, and a 2-year survival in 52% of cases. A correlation between the localization of lesions and response rate has been found. The best results have been achieved in localized lesions and lymph nodes metastases. Low toxicity of the drug enables achievement of results comparable to those seen in all types of the hormonal therapy, except androgens.

[Toxicity and efficacy of chemotherapy dependent on circadian time of cytostatic drug administration]. / Toksycznosc i skutecznosc chemioterapii w zaleznosci od pory dnia podawania cytostatyków.

A prospective, controlled study was carried out in order to evaluate efficacy and toxicity of chemotherapy based on cisplatin in dependence on the circadian rhythm of drugs administration in patients with testicular and ovarian cancer. The study included 80 patients (40 with testicular cancer and 40 with ovarian cancer), divided into two groups (A and B). The cytostatics were administered in the evening in the group A and in the morning in the group B. The response rates and the 3-years survival rates were comparable in both groups. However the patients in the group A presented less haematological and renal side effects, while nausea and vomiting were milder. Chronotherapy may appear to be a method improving the tolerance of chemotherapy based on cisplatin.

[Late hematologic status after chemotherapy observed in patients 3 to 10 years after treatment]. / Pózne powiklania hematologiczne po leczeniu chemicznym obserwowane u pacjentów w 3 do 10 lat po leczeniu.

The aim of the present study is the evaluation of late hematological complication in patients who received aggressive chemotherapy, and were observed 3, 5 and 10 years after treatment was completed. In the group of 35 patients, besides high percent of early hematological complications, there was only one case of anemia grade 2 (acc. to WHO score). We concluded that the hematological recovery after aggressive chemotherapy was satisfactory. No secondary hematological malignancies have been found.

[Role of chemotherapy in the treatment of anaplastic thyroid cancer --personal observations]. / Rola chemioterapii w leczeniu anaplastycznego raka tarczycy--doswiadczenia wlasne.

Results of chemotherapy applied in 23 patients with anaplastic thyroid cancer are presented. Chemotherapy combined with local treatment is a suggested therapy for treatment the locally advanced anaplastic thyroid cancer.